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1、浙江大學(xué)博士學(xué)位論文基于腦磁圖的磁源參數(shù)計(jì)算姓名:李軍申請(qǐng)學(xué)位級(jí)別:博士專業(yè):生物醫(yī)學(xué)工程指導(dǎo)教師:汪元美2000.5.1浙江大學(xué)博士學(xué)位論文摘要ABSTRACTMagnetoencephalography(MEGlisanoninvasivetechniqueforinvestigatingneuronalactivityinthelivinghumanbrainThetimeresolutionofthemethodisbetter

2、thanlmsandthespatialdiscriminationisabout24mmforsourcesinthecerebralcortexInMEGstudies,theweakmagneticfield,typically50500frproducedbyelectriccurrentsflowinginneuronsagemeasuredwithmultichannelSQUID(superconductingquantu

3、minterferencedevice)magnetometersThesitesinthecerebralcortexthatareactivatedbyastimuluscanbefoundfromthedetectedmagneticfielddistribution,providedthatappropriateassumptionsaboutthesourcerenderthesolutionoftheinverseprobl

4、emuniqueManyinterestingpropertiesoftheworkinghumanbraincanbestudied,includingspontaneousactivityandsignalprocessingfollowingexternalstimuliForclinicalpurposes,determinationofthelocationsofepilepticfociisofinterestThispap

5、erisfocusedonthemagnetoencephalographicinverseproblemsolutionandisorganizedasthefollowingsixchaptersInchapter1,anoverviewisgivenonmagnetoencephalographyincludingabriefhistoryaboutthemajormilestonesonbiomagneticstudies,de

6、tailedintroductiontoMEGtheoreticaldevelopments,andsomepresentandpotentialclinicalapplicationsInchapter2,firstlytheneuralbasisofMEGisdiscussed,especiallythepostsynapticpotentialswhichagegenerallyconsideredasbioelectromagn

7、eticsourcesSecondlythemainprinciplesofSQUmareexplainedInchapter3,thebasicmathematicalandelectromagneticconceptsarethoroughlydiscussed,includinggeneralMaxwellequations,thequasistaticapproximationonbioelectromagneticstudie

8、s,Geselowitzformulasusedtocomputeelectromagneticfieldsinpiecewisehomogeneousconductors,MEGforwardandinverseproblemswhicharediscussedingeneralwaysandwithsomenewapproachesInchapter4,someoptimizationmethods,includinggradien

9、talgorithmanimprovedGaussNewtonalgorithmandsimulatedannealingalgorithmageusedinM匝GinversionIncomparisongradientGaussNewtonalgorithmsareoffastcomputationspeedwhilesimulatedannealingcostsmoretimeOntheotherhand,simulatedann

10、ealingalmosthasnospecialneedfortheselectionofinitialiterativevalueswhilegradient,GaussNewtonalgorithmshaveittosomeextentFromcomputersimulationthefollowingconclusioniSdrawn:Onestimatingoneortwosourceparameters,lOCaloptimi

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