生化網絡數據服務系統的設計與實現.pdf

1、中國科學技術大學碩士學位論文生化網絡數據服務系統的設計與實現姓名：王強申請學位級別：碩士專業(yè)：計算機應用技術指導教師：岳麗華20050501璺型堂塾查叁堂嬰主堂!!絲蘭壘墜竺!t_ABSTRACTTherapiddevelopmentsoftechnologiesinbiologyespeciallyinmolecularbiologymaketOffSofbiologicaldata，whichrequestmorepowerfulc

2、omputersandsoftwaretoolsThisdissertationmakesasystematicandthoroughstudyonseveralkeyissuesonbiologicalSOftwaredevelopmentManysoftwaretoolsdevelopedforspecialpurposes，butfewofthemarcreusableandextensible，andworktogethersm

3、oothlyandintegrativelyTherefore，wedesignaJ2EE。basedplatformtosupportbioinfonnaticsresearchInheritedfromJ2EEarchitecture，thisplatformisreusableandextensibleTheplatformneedsatheoreticalmodelsupportInthepaststudies，manydata

4、modelareproposedtoinvestigatethebiomolecularinteractionsMostofthemusethemethodsofgraphtheory：WeintroducethePetrinet，awidelyusedmodelingtoolfordiscreteeventsTheextendedPetfinetcanwelldescribethedynamicalbehaviorofbiochemi

5、calnetworks，especiallyofmetabolicnetworksAndwedevelopagraphicaleditorbasedonthismodelingsystemAsakeymodule，thedatabaseiswelldiscussedanddesigned，Presentlymanydatabasesaboutbiochemicalnetworksaledevelopedwithdifferentfocu

6、sesWedetailedlyinvestigatetheapplicationsandresearches0npathwaydatabases，thesourcesofpathwaydataandtechnologiesusedbythosedatabasesOurdatabaserecruitsPostgreSQLastheDBMS，Hibernateasobjectrelationmappingmodule，BioCycasdat

7、aSOUreesFinallyweemphasizethekeyroleofthevisualizationofbiochemicalnetworksplayedinsystemsbiologyresearchesWecomparemanydescribingmethodsofbiochemicalnetworks，andindicatetheimportanceofthevisualizationAnSVGbasedvisualiza

8、tionframeworkiSdevelopedtosupportthevisualizationoflargenetworksComparedwithpreviousresearches，thenewcontributionsofthepaperare：(1)Fromtheviewpointofsottwareintegration，designsaplatformbasedonJ2EE，whichiSreusableandexten

9、sibler2、JntroducesPetfinetasthedatamodelof’biochemicaInetworks，whichmeetstheneedofthemodelingofcellulardynamicsverywell，Wealsodevelopagraphicaltooltosupportmodeledit(3)Designsanewbiochemicaldatabase(4)Presentsavisualizat