Solubility and Particles Formation of Bicalutamide Using Subcritical Water Technology.pdf

1、The application of Subcritical water technology in improving the bioavailability ofhydrophobic water insoluble drugs, active pharmaceutical ingredients was reported in thisthese.In this research work, the solubility and

2、the nanoparticles generation of the class Ⅱ anticancer anti androgen bicalutamide oral drug were studied at temperature ranging from 110℃to 180℃and constant pressure of 5.5 MPa.The experiments were performed using a modi

3、fysolvent anti solvent method combined with a subcritical water technology.The chemical andphysical characteristics including the stability and the crystallinity of the processed drugsamples was analysed under X-Ray Diff

4、raction (XRD) Technique followed by FourierTransformed Infra-Red (FTIR) Techniques.Statistical analyses were performed on theexperimental data.The solubility data obtained were correlated using a modify Apelblatmodel.The

5、 Van't Hoff equation was used to determine the thermodynamic parametersincluding the molar enthalpy (ΔHsol), molar entropy (ΔSsol), and the molar Gibbs free energy(ΔGsol) from the experimental solubility data.
　　The n

6、anoparticles were generated under various collection media temperatures andconcentration conditions.Different pharmaceutical excipients/surfactants such as lactosemonohydrate, polyethylene glycol, and sodium lauryl sulfa

7、te were used for the particlesmorphology, size and distribution control.The scanning electron microscopy (SEM) analysiswas performed on the processed drug nanoparticles.The syntheses of nanoparticles up to 40nm with unif

8、ormity in morphology were achieved.The dissolution study of the synthesizednanoparticles drug was carried out.The size distribution analysis was also carried out usingImage J software and the normal distribution was corr

9、elated using nonlinear (Gaussianfunction) fitting.
　　The results of the predicted solubility show good agreement with the experimental valuesproving accurate dependency of solubility to the temperature.Important impro

10、vement in thesize and morphology of the bicalutamide drug particles was achieved including enhancementin the bioavailability of the drug.The subcritical water technology has shown to be promisingin developing pharmaceuti