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1、青島大學(xué)碩士學(xué)位論文地塞米松和西比靈對慶大霉素耳毒性的保護作用姓名：張俊瑤申請學(xué)位級別：碩士專業(yè)：耳鼻咽喉頭頸外科指導(dǎo)教師：朱富高20100520AbstractObjectiveTostudytheprotectiveeffectofdexamethasoneandflunarizineongentamicinototoxicity’MethodsFortyguineapigswererandomlydividedintofifveg

2、roups，F(xiàn)oreachgroup，onDay1pretreatmentauditorybrainstemevokedresponse(ABR)peaklatencyandinterpeaklatencywereobtainedpriortoinjectionofgentamicinGentamicingroupwasdailyinjectedwith150mg／kgofgentamicinbyintramuscularandinje

3、ctedwith05mlofnormalsalineinabdominalsubcutaneousProtectiongroupincludedthreegroups：DFgroupwasdailyinjectedwith150mg／kgofgentamicinbyintramuscularandinjectedwith3mg／kgofdexamethasoneinabdominalsubcutaneous，administeredwi

4、th3mg／kgofflunarizineDgroupwasdailyinjectedwith150mg／kgofgentamicinbyintramuscularandinjectedwith3mg／kgofdexamethasoneinabdominalsubcutaneousFgroupWasdailyinjectedwith150mg／kgofgentamicinbyintramuscularandadministeredwit

5、h3mg／kgofflunarizineControlgroupweredailyinjectedwith3ml／kgofnormalsalinebyintramuscularandinjected05mlinabdominalsubcutaneousEachgroupweretreatedfortccndaysPost—treatmentABRpeaklatencyandinterpeaklatencywerethenrecorded

6、onDayfifteen，everyguineapigsineachgroupweretestPreandposttreatmentpeaklatencyandinterpeaklatencywerecomparedtomeasurethesechangesHistologychangesofhaircellwereobservedafterABRtestit’Sincludemorphologyofhaireellbyhematoxy

7、linstainedandthenumberofapoptotichaircellsbyTUNELstainedResults(④TherewassignificantdifferencebetweenPreandposttreatmentpeaklatencyandinterpeaklatencyonGentamicingroupandProtectiongroupneposttreatmentpeaklatencyandinterp

8、eaklatencyonProtectiongroup(exceptDgroup)wereshorterthanGentamicingroup，andDFgroupshorterthanFgroup(PO05)(室)Hematoxylinstained：ForGentamicingroupandDgroup，alargenumberofouterhaircellmissingandarrangeddisorderedly；ForDFgr

9、oupandFgroup，outerhaircellsarrangedirregularlyandfewcellsloss；ForControlgrouptherewerenoouterhaireelllOSSandthesecellsarrangedregularly@TUNELstained：ThenumberofapoptosishaircellsofModelgroupandProtectiongroupmorethanthat

10、ofControlgroup(PO05)TherewassignificantdifferencebetweenthenumberofModelgroupandthatofProtectiongroup(P005)ConclusionsGentamicincaninduceapoptosisofcochlearhaircells；Flunarizineanddexamethasonecombinedflunarizinecanreduc

11、egentamicininducedcochlearhaircells，andprotecthearing，buttheprotectiveeffectofdexamethasonecombinedflunarizinewercbetterthanfiunarizinealonesmalldosesofdexamethasoneifitusedsinglelyhavenoprotectiveeffectforgentamicin—ind

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