眾賞文庫(kù)
全部分類
  • 抗擊疫情 >
    抗擊疫情
    病毒認(rèn)知 防護(hù)手冊(cè) 復(fù)工復(fù)產(chǎn) 應(yīng)急預(yù)案 防控方案 英雄事跡 院務(wù)工作
  • 成品畢設(shè) >
    成品畢設(shè)
    外文翻譯 畢業(yè)設(shè)計(jì) 畢業(yè)論文 開題報(bào)告 文獻(xiàn)綜述 任務(wù)書 課程設(shè)計(jì) 相關(guān)資料 大學(xué)生活 期刊論文 實(shí)習(xí)報(bào)告
  • 項(xiàng)目策劃 >
    項(xiàng)目策劃
    土地準(zhǔn)備 規(guī)劃設(shè)計(jì) 開工開盤 項(xiàng)目綜合 竣工移交 售后移交 智慧方案 安全專項(xiàng) 環(huán)境影響評(píng)估報(bào)告 可行性研究報(bào)告 項(xiàng)目建議書 商業(yè)計(jì)劃書 危害評(píng)估防治 招投標(biāo)文件
  • 專業(yè)資料 >
    專業(yè)資料
    人文法律 環(huán)境安全 食品科學(xué) 基礎(chǔ)建設(shè) 能源化工 農(nóng)林牧畜 綜合待分類 教育經(jīng)驗(yàn) 行政人力 企業(yè)管理 醫(yī)學(xué)衛(wèi)生 IT技術(shù) 土木建筑 考研專題 財(cái)會(huì)稅務(wù) 公路隧道 紡織服裝
  • 共享辦公 >
    共享辦公
    總結(jié)匯報(bào) 調(diào)研報(bào)告 工作計(jì)劃 述職報(bào)告 講話發(fā)言 心得體會(huì) 思想?yún)R報(bào) 事務(wù)文書 合同協(xié)議 活動(dòng)策劃 代理加盟 技術(shù)服務(wù) 求職簡(jiǎn)歷 辦公軟件 ppt模板 表格模板 融資協(xié)議 發(fā)言演講 黨團(tuán)工作 民主生活
  • 學(xué)術(shù)文檔 >
    學(xué)術(shù)文檔
    自然科學(xué) 生物科學(xué) 天文科學(xué) 醫(yī)學(xué)衛(wèi)生 工業(yè)技術(shù) 航空、航天 環(huán)境科學(xué)、安全科學(xué) 軍事 政學(xué) 文化、科學(xué)、教育、 交通運(yùn)輸 經(jīng)濟(jì) 語(yǔ)言、文字 文學(xué) 農(nóng)業(yè)科學(xué) 社會(huì)科學(xué)總論 藝術(shù) 歷史、地理 哲學(xué) 數(shù)理科學(xué)和化學(xué) 綜合性圖書 哲學(xué)宗教
  • 經(jīng)營(yíng)營(yíng)銷 >
    經(jīng)營(yíng)營(yíng)銷
    綜合文檔 經(jīng)濟(jì)財(cái)稅 人力資源 運(yùn)營(yíng)管理 企業(yè)管理 內(nèi)控風(fēng)控 地產(chǎn)策劃
  • 教學(xué)課件 >
    教學(xué)課件
    幼兒教育 小學(xué)教育 初中教育 高中教育 職業(yè)教育 成人教育 高等教育 考研資源 試題真題 作業(yè)習(xí)題 課后答案 綜合教學(xué)
  • 土木建筑 >
    土木建筑
    專項(xiàng)施工 應(yīng)急預(yù)案 建筑規(guī)范 工藝方案 技術(shù)交底 施工表格 圖片圖集
  • 課程導(dǎo)學(xué) >
    課程導(dǎo)學(xué)
    醫(yī)學(xué)綜合 中醫(yī)養(yǎng)生 醫(yī)學(xué)研究 身心發(fā)展 醫(yī)學(xué)試題 影像醫(yī)學(xué) 醫(yī)院辦公 外科醫(yī)學(xué) 老年醫(yī)學(xué) 內(nèi)科醫(yī)學(xué) 婦產(chǎn)科 神經(jīng)科 醫(yī)學(xué)課件 眼鼻喉科 皮膚病科 腫瘤科 兒科醫(yī)學(xué) 康復(fù)醫(yī)學(xué) 全科醫(yī)學(xué) 護(hù)理學(xué)科 針灸學(xué)科 重癥學(xué)科 病毒學(xué)科 獸醫(yī) 藥學(xué)
    • 簡(jiǎn)介:JOURNALOFMATERIALSPROCESSINGTECHNOLOGY142200320–28DELTAFERRITEPREDICTIONINSTAINLESSSTEELWELDSUSINGNEURALNETWORKANALYSISANDCOMPARISONWITHOTHERPREDICTIONMETHODSMVASUDEVANA,?,AKBHADURIA,BALDEVRAJA,KPRASADRAOBAMETALLURGYANDMATERIALSGROUP,INDIRAGANDHICENTREFORATOMICRESEARCH,KALPAKKAM,INDIABDEPARTMENTOFMETALLURGY,INDIANINSTITUTEOFTECHNOLOGY,CHENNAI,INDIARECEIVED2MAY2002RECEIVEDINREVISEDFORM11DECEMBER2002ACCEPTED17FEBRUARY2003ABSTRACTTHEABILITYTOPREDICTTHEDELTAFERRITECONTENTINSTAINLESSSTEELWELDSISIMPORTANTFORMANYREASONSDEPENDINGONTHESERVICEREQUIREMENT,MANUFACTURERSANDCONSUMERSOFTENSPECIFYDELTAFERRITECONTENTASANALLOYSPECIFICATIONTOENSURETHATWELDCONTAINSADESIREDMINIMUMORMAXIMUMFERRITELEVELRECENTRESEARCHACTIVITIESHAVEBEENFOCUSEDONSTUDYINGTHEEFFECTOFVARIOUSALLOYINGELEMENTSONTHEDELTAFERRITECONTENTANDCONTROLLINGDELTAFERRITECONTENTBYMODIFYINGTHEWELDMETALCOMPOSITIONSOVERTHEYEARS,ANUMBEROFMETHODSINCLUDINGCONSTITUTIONDIAGRAMS,FUNCTIONFITMODEL,FEEDFORWARDBACKPROPAGATIONNEURALNETWORKMODELHAVEBEENPUTFORWARDFORPREDICTINGTHEDELTAFERRITECONTENTINSTAINLESSSTEELWELDSAMONGALLTHEMETHODS,NEURALNETWORKMETHODWASREPORTEDTOBEMOREACCURATECOMPAREDTOOTHERMETHODSAPOTENTIALRISKASSOCIATEDWITHNEURALNETWORKANALYSISISOVERFITTINGOFTHETRAININGDATATOAVOIDOVERFITTING,MACKAYHASDEVELOPEDABAYESIANFRAMEWORKTOCONTROLTHECOMPLEXITYOFTHENEURALNETWORKMAINADVANTAGESOFTHISMETHODARETHATITPROVIDESMEANINGFULERRORBARSFORTHEMODELPREDICTIONSANDALSOITISPOSSIBLETOIDENTIFYAUTOMATICALLYTHEINPUTVARIABLESWHICHAREIMPORTANTINTHENONLINEARREGRESSIONINTHEPRESENTWORK,BAYESIANNEURALNETWORKBNNMODELFORPREDICTIONOFDELTAFERRITECONTENTINSTAINLESSSTEELWELDHASBEENDEVELOPEDTHEEFFECTOFVARYINGCONCENTRATIONOFTHEELEMENTSONTHEDELTAFERRITECONTENTHASBEENQUANTIFIEDFORTYPE309AUSTENITICSTAINLESSSTEELANDTHEDUPLEXSTAINLESSSTEELALLOY2205THEBNNMODELISFOUNDTOBEMOREACCURATECOMPAREDTOTHATOFTHEOTHERMETHODSFORPREDICTINGDELTAFERRITECONTENTINSTAINLESSSTEELWELDS?2003ELSEVIERSCIENCEBVALLRIGHTSRESERVEDKEYWORDSNEURALNETWORKANALYSISDELTAFERRITECONTENTAUSTENITICSTAINLESSSTEELDUPLEXSTAINLESSSTEEL1INTRODUCTIONTHEABILITYTOESTIMATETHEDELTAFERRITECONTENTACCURATELYHASPROVENVERYUSEFULINPREDICTINGTHEVARIOUSPROPERTIESOFAUSTENITICSSWELDSAMINIMUMDELTAFERRITECONTENTISNECESSARYTOENSUREHOTCRACKINGRESISTANCEINTHESEWELDS1,2,WHILEANUPPERLIMITONTHEDELTAFERRITECONTENTDETERMINESTHEPROPENSITYTOEMBRITTLEMENTDUETOSECONDARYPHASES,EGSIGMAPHASE,ETC,FORMEDDURINGELEVATEDTEMPERATURESERVICE3ATCRYOGENICTEMPERATURES,THETOUGHNESSOFTHEAUSTENITICSSWELDSISSTRONGLYINFLUENCEDBYTHEDELTAFERRITECONTENT4INDUPLEXSTAINLESSSTEELWELDMETALS,ALOWERFERRITELIMITISSPECIFIEDFORSTRESSCORROSIONCRACKINGRESISTANCEWHILETHEUPPERLIMITISSPECIFIEDTOENSUREADEQUATEDUCTILITYANDTOUGHNESS5HENCE,DEPENDINGONTHESERVICEREQUIREMENTALOWERLIMITAND/ORANUPPERLIMITONDELTAFERRITECONTENTISGENERALLYSPECIFIEDDURINGTHESELEC?CORRESPONDINGAUTHORTEL91411480232FAX91411440381EMAILADDRESSDEVIGCARERNETINMVASUDEVANTIONOFFILLERMETALCOMPOSITION,THEMOSTACCURATEDIAGRAMTODATEWRC1992ISUSEDGENERALLYTOESTIMATETHE?FERRITECONTENT6THECREQANDNIEQFORMULAEUSEDFORGENERATINGTHEWRC1992CONSTITUTIONDIAGRAMISGIVENBYCREQCRMO07NBANDNIEQNI35C20N025CUTHELIMITATIONOFTHESEEQUATIONSISTHATVALUESOFTHECOEFFICIENTSFORTHEDIFFERENTELEMENTSREMAINUNCHANGEDIRRESPECTIVEOFTHECHANGEINTHEBASECOMPOSITIONOFTHEWELDHOWEVER,THERELATIVEINFLUENCEOFEACHALLOYINGADDITIONGIVENBYTHEELEMENTALCOEFFICIENTSINTHECREQANDNIEQEXPRESSIONSISLIKELYTOCHANGEOVERTHEFULLCOMPOSITIONRANGEFURTHERMORE,THESEEXPRESSIONSIGNORETHEINTERACTIONBETWEENTHEELEMENTSALSO,THEREAREANUMBEROFALLOYINGELEMENTSTHATHAVENOTBEENCONSIDEREDINTHEWRC1992DIAGRAMELEMENTSLIKESI,TI,WHAVENOTBEENGIVENDUETOCONSIDERATIONS,THOUGHTHEYAREKNOWNTOINFLUENCETHEDELTAFERRITECONTENTHENCE,THEDELTAFERRITECONTENTESTIMATEDUSINGTHEWRC1992DIAGRAMWOULDALWAYSBELESSACCURATEANDMAYNEVERBECLOSETOTHEACTUALMEASUREDVALUEINTHEFUNCTIONFITMODEL7FORESTIMATINGFERRITE,THEDIFFERENCEINFREEENERGYBETWEENTHEFERRITEANDTHEAUSTENITEWASCALCULATED09240136/–SEEFRONTMATTER?2003ELSEVIERSCIENCEBVALLRIGHTSRESERVEDDOI101016/S092401360300430822MVASUDEVANETAL/JOURNALOFMATERIALSPROCESSINGTECHNOLOGY142200320–28FIG1SCHEMATICDIAGRAMOFTHENETWORKSTRUCTURESHOWINGTHEINPUTNODES,HIDDENUNITSANDTHEOUTPUTNODEFUNCTIONSOTHATEACHINPUTCONTRIBUTESTOEVERYHIDDENUNIT,WHERENISTHETOTALNUMBEROFINPUTVARIABLESHITANH??N?JW1IJXJΘ1I??3HERETHEBIASISDESIGNATEDASΘANDISANALOGOUSTOTHECONSTANTINLINEARREGRESSIONTHETRANSFERFROMTHEHIDDENUNITSTOTHEOUTPUTISLINEAR,ANDISGIVENBYYN?IW2IHIΘ24THEOUTPUTYISTHEREFOREANONLINEARFUNCTIONOFXJ,WITHTHEFUNCTIONUSUALLYSELECTEDFORFLEXIBILITYBEINGTHEHYPERBOLICTANGENTTHUS,THENETWORKISCOMPLETELYDESCRIBEDIFTHENUMBEROFINPUTNODES,OUTPUTNODESANDTHEHIDDENUNITSAREKNOWNALONGWITHALLTHEWEIGHTSWIJANDBIASESΘITHESEWEIGHTSWIJAREDETERMINEDBYTRAININGTHENETWORKANDINVOLVESMINIMIZATIONOFAREGULARIZEDSUMOFSQUAREDERRORSTHEBNNANALYSISOFMACKAY10ALLOWSTHECALCULATIONOFERRORBARSWITHTWOCOMPONENTSONEREPRESENTINGTHEPERCEIVEDLEVELOFNOISEΣVINTHEOUTPUTANDTHEOTHERINDICATINGTHEUNCERTAINTYINTHEDATAFITTINGTHISLATTERCOMPONENTOFTHEERRORBARSEMANATINGFROMTHEBAYESIANFRAMEWORKALLOWSTHERELATIVEPROBABILITIESOFTHEMODELSWITHDIFFERENTCOMPLEXITYTOBEASSESSEDTHISENABLESESTIMATIONOFQUANTITATIVEERRORBARS,WHICHVARYWITHTHEPOSITIONINTHEINPUTSPACEDEPENDINGONTHEUNCERTAINTYINFITTINGTHEFUNCTIONINTHATSPACEHENCE,INSTEADOFCALCULATINGAUNIQUESETOFWEIGHTS,APROBABILITYDISTRIBUTIONOFWEIGHTSISUSEDTODEFINETHEUNCERTAINTYINFITTINGTHEREFORE,THESEERRORBARSBECOMELARGEWHENDATAARESPARSEORLOCALLYNOISYINTHISCONTEXT,AVERYUSEFULMEASUREOFTHEERRORISTHELOGARITHMOFTHEPREDICTIVEERRORLPEGIVENBYTHEFOLLOWINGLPE?N12?TN?YN2ΣN2YLOG2ΠΣNY1/2?5WHERETISTHETARGETFORTHESETOFINPUTSX,WHILEYTHECORRESPONDINGNETWORKOUTPUTΣYISRELATEDTOTHEUNCERTAINTYOFFITTINGFORTHESETOFINPUTSXBYUSINGLPE,THEPENALTYFORMAKINGAWILDPREDICTIONISREDUCEDIFTHATPREDICTIONISACCOMPANIEDBYANAPPROPRIATELYLARGEERRORBAR,WITHALARGERVALUEOFTHELPEIMPLYINGABETTERMODELFURTHER,BYTHISMETHODITISALSOPOSSIBLETOAUTOMATICALLYIDENTIFYTHEINPUTVARIABLESTHATARESIGNIFICANTININFLUENCINGTHEOUTPUTVARIABLE,ASTHEINPUTVARIABLESTHATARELESSSIGNIFICANTAREDOWNWEIGHTEDINTHEREGRESSIONANALYSIS31OVERFITTINGPROBLEMINBNNANALYSIS,TWOSOLUTIONSAREIMPLEMENTEDWHICHCONTRIBUTETOAVOIDOVERFITTINGTHEFIRSTISCONTAINEDINTHEALGORITHMDUETOMACKAY12THECOMPLEXITYPARAMETERSΑANDΒAREINFERREDFROMTHEDATA,THEREFOREALLOWINGAUTOMATICCONTROLOFTHEMODELCOMPLEXITYTHESECONDRESIDESINTHETRAININGMETHODTHEDATABASEISEQUALLYDIVIDEDINTOATRAININGSETANDATESTINGSETTOBUILDAMODEL,ABOUT80NETWORKSARETRAINEDWITHDIFFERENTNUMBEROFHIDDENUNITSANDSEEDS,USINGTHETRAININGSETTHEYARETHENUSEDTOMAKEPREDICTIONSONTHEUNSEENTESTINGSETANDARERANKEDBYLPE32COMMITTEEMODELTHENETWORKSWITHDIFFERENTNUMBEROFHIDDENUNITSWILLGIVEDIFFERENTPREDICTIONSBUTPREDICTIONSWILLALSODEPENDONTHEINITIALGUESSMADEFORTHEPROBABILITYDISTRIBUTIONOFTHEWEIGHTSTHEPRIOROPTIMUMPREDICTIONSAREOFTENMADEUSINGMORETHANONEMODEL,BYBUILDINGACOMMITTEETHEPREDICTIONˉYOFACOMMITTEEOFNETWORKSISTHEAVERAGEPREDICTIONOFITSMEMBERS,ANDTHEASSOCIATEDERRORBARISCALCULATEDACCORDINGTOEQ6ˉY1L?LYLΣ21L?LΣL2Y1L?LYL?ˉY26WHERELISTHENUMBEROFNETWORKSINACOMMITTEENOTETHATWENOWCONSIDERTHEPREDICTIONSFORAGIVENSINGLESETOFINPUTSANDTHATEXPONENTLREFERSTOTHEMODELUSEDTOPRODUCETHECORRESPONDINGPREDICTIONYLINPRACTICE,ANINCREASINGNUMBEROFNETWORKSAREINCLUDEDINACOMMITTEEANDTHEIR
      下載積分: 10 賞幣
      上傳時(shí)間:2024-03-13
      頁(yè)數(shù): 9
      11人已閱讀
      ( 4 星級(jí))
    • 簡(jiǎn)介:MIXEDDSP/FPGAIMPLEMENTATIONOFANERRORRESILIENTIMAGETRANSMISSIONSYSTEMBASEDONJPEG2000MARCOGRANGETTO,ENRICOMAGLI,MAURIZIOMARTINA,FABRIZIOVACCACERCOMCENTERFORWIRELESSMULTIMEDIACOMMUNICATIONSDIPARTIMENTODIELETTRONICAPOLITECNICODITORINOCORSODUCADEGLIABRUZZI2410129TORINOITALYGRANGETTOMAGLIPOLITOITMARTINAVACCAVLSILABOLPOLITOITPH390115644195FAX39011564099ABSTRACTTHISPAPERDESCRIBESADEMONSTRATOROFANERRORRESILIENTIMAGECOMMUNICATIONSYSTEMOVERWIRELESSPACKETNETWORKS,BASEDONTHENOVELJPEG2000STANDARDINPARTICULAR,THEDECODERIMPLEMENTATIONISADDRESSED,WHICHISTHEMOSTCRITICALTASKINTERMSOFCOMPLEXITYANDPOWERCONSUMPTION,INVIEWOFUSEONAWIRELESSPORTABLETERMINALFORCELLULARAPPLICATIONSTHESYSTEMIMPLEMENTATIONISBASEDONAMIXEDDSP/FPGAARCHITECTURE,WHICHALLOWSTOPARALLELIZESOMECOMPUTATIONALTASKS,THUSLEADINGTOEFICIENTSYSTEMOPERATION1INTRODUCTION’NOWADAYS,THEREISAGROWINGINTERESTINTHEENDTOENDTRANSMISSIONOFIMAGES,ESPECIALLYMOTIVATEDBYTHESHORTTERMDEPLOYMENTOFNEXTGENERATIONMOBILECOMMUNICATIONSERVICESUMTSIMT2000HOWEVER,TRANSMISSIONINANETWORKED,TETHERLESSENVIRONMENTPROVIDESBOTHOPPORTUNITIESANDCHALLENGESTHEWIRELESSCONTEXTIMPLIESTHATTHEDATAMAYUNDERGOBITERRORSANDPACKETLOSSES,MAKINGITNECESSARYTOFORESEEERRORRECOVERYMODALITIESITISTHEREBYNECESSARYTHATIMAGECOMMUNICATIONTECHNIQUESAREPROVIDEDWITHTHEABILITYTORECOVER,ORATLEASTCONCEAL,THEEFFECTOFSUCHLOSSESTHEFORTHCOMINGJPEG2000IMAGECOMPRESSIONSTANDARDHASBEENDESIGNEDTOMATCHTHESEREQUIREMENTS,ANDEMBEDSSOMEERRORDETECTIONANDCONCEALMENTTOOLSTHISPAPERADDRESSESTHEDEVELOPMENTOFADEMONSTRATOROFANERRORRESILIENTJPEG2000111DECODERIMPLEMENTATIONFORIMAGECOMMUNICATIONOVERALOSSYPACKETNETWORKTHEROBUSTNESSTOPACKETERASURESISACHIEVEDBYCOMBININGTHEFLEXIBILITYOFTHEJPEG2000FRAMEWORKWITHTHEPOWERFULNESSOFSOURCECHANNEL078037147X/01/100002001IEEEADAPTIVE,OPTIMIZEDREEDSOLOMONCODESTHEDECODERIMPLEMENTATIONISPARTICULARLYSIGNIFICANTINTHECONTEXTOFWIRELESSPORTABLETERMINALSFORNEXTGENERATIONCELLULARSYSTEMS,WHERETHELIMITEDPOWERBUDGETANDAVAILABLEDIMENSIONSIMPOSESEVERECONSTRAINTSONTHEDESIGNOFAMULTIMEDIAPROCESSINGSYSTEM2SYSTEMOVERVIEWTHEFUNCTIONALUNITSOFTHEIMPLEMENTEDSYSTEM21JPEG2000IMAGECOMPRESSIONJPEG2000ISTHENOVELIS0STANDARDFORSTILLIMAGECODING,ANDISINTENDEDTOPROVIDEINNOVATIVESOLUTIONSACCORDINGTOTHENEWTRENDSINMULTIMEDIATECHNOLOGIESATTHETIMEOFTHISWRITING,THESTANDARDISINADVANCEDPUBLICATIONSTAGETHEFINALCOMMITTEEDRAFTLISTHEMOSTRECENTJPEG2000DESCRIPTIONPUBLICLYAVAILABLE,WHICHOURIMPLEMENTATIONCONFORMSTOJPEG2000NOTONLYYIELDSSUPERIORPERFORMANCEWITHRESPECTTOEXISTINGSTANDARDSINTERMSOFCOMPRESSIONCAPABILITYANDSUBJECTIVEQUALITY,BUTALSONUMEROUSADDITIONALFUNCTIONALITIES,SUCHASIOSSLESSANDLOSSYCOMPRESSION,PROGRESSIVETRANSMISSION,ANDERRORRESILIENCETHEARCHITECTUREOFTHEJPEG2000ISBASEDONTHETRANSFORMCODINGAPPROACHANIMAGEMAYBEDIVIDEDINTOSEVERALSUBIMAGESTILES,TOREDUCEMEMORYANDCOMPUTINGREQUIREMENTSABIORTHOGONALDISCRETEWAVELETTRANSFORMDWTISFIRSTAPPLIEDTOEACHTILE,WHOSEOUTPUTISASERIESOFVERSIONSOFTHETILEATDIFFERENTRESOLUTIONLEVELSSUBBANDSTHEN,THETRANSFORMCOEFFICIENTSAREQUANTIZED,INDEPENDENTLYFOREACHSUBBAND,WITHANEMBEDDEDDEADZONEQUANTIZEREACHSUBBANDOFTHEWAVELETDECOMPOSITIONISDIVIDEDINTORECTANGULARBLOCKSCODEBLOCKS,WHICHAREININTHEFOLLOWINGWEPROVIDEABRIEFDESCRIPTIONOF1330CODETHERECEIVEDBITSTREAMMAKESTHEUSEOFAREEDSOLOMONFPGAIMPLEMENTATIONVERYATTRACTIVETHEJPEG2000DECODERMODULE,ENTIRELYIMPLEMENTEDONDSP,ISCOMPOSEDBYFOURMAINBLOCKSSYNTAXPARSER,ENTROPYDECODEREBCOT,UNIFORMSCALARDEQUANTIZER,ANDINVERSEWAVELETTRANSFORMMOREOVER,TWOADDITIONALTASKS,DEVOTEDTOCOMMUNICATIONMANAGEMENTBETWEENDSP,FPGAANDAPERSONALCOMPUTER,HAVEBEENINTRODUCED31SYNTAXPARSERTHEPARSERISTHEFUNCTIONALBLOCKTHATINTERFACESTHEJPEG2000DECODERWITHTHERSDECODERITRETRIEVESRSDECODEDPACKETS,ANDEXTRACTSFROMTHECOMPRESSEDJPEG2000BITSTREAMALLTHERELEVANTINFORMATIONNEEDEDTOPERFORMIMAGERECONSTRUCTIONFIRSTLY,THEBITSTREAMMAINHEADERISREAD,WHICHCONTAINSINFORMATIONONTHEPARAMETERSUSEDDURINGTHEENCODINGPROCESSEGIMAGESIZE,WAVELETFILTERUSED,NUMBEROFDECOMPOSITIONLEVELS,QUANTIZATIONTHRESHOLDS,ANDSOONAFTERTHAT,TILEHEADERSAREREAD,WHICHPROVIDEINFORMATIONSPECIFICTOEACHIMAGETILEFINALLY,EACHPACKETCONTAINEDINTHEBITSTREAMISREAD,ANDTHEDATAANDPARAMETERSOFEACHCODEBLOCKAREEXTRACTED,ANDFEDASINPUTSTOTHEEBCOTDECODER32EBCOTRIGHTAFTERTHEBITSTREAMSYNTAXPARSER,THESUBSEQUENTSTAGEINTHEJPEG2000DECOMPRESSIONCHAINISTHEENTROPYDECODEREBCOTFROMANALGORITHMICPOINTOFVIEW,EBCOTISABLOCKBASEDBITPLANEENCODERFOLLOWEDBYAREDUCEDCOMPLEXITYARITHMETICCODERMQITSUBDIVIDESEACHWAVELETSUBBANDINTOADISJOINTSETOFRECTANGULARBLOCKS,CALLEDCODEBLOCKSTHENTHECOMPRESSIONALGORITHMISINDEPENDENTLYAPPLIEDTOEVERYCODEBLOCKTHESAMPLESOFEVERYCODEBLOCKAREARRANGEDINTOSOCALLEDBITPLANESTODECODEACODEBLOCK,EBCOTALWAYSSTARTSFROMTHEMOSTSIGNIFICANTBITPLANES,ANDTHENMOVESTOWARDSTHELEASTSIGNIFICANTONESTHECOMPRESSEDINFORMATIONOFEVERYCODEBLOCKISTHENARRANGEDINSEVERALQUALITYLAYERS,TOCREATEASCALABLECOMPRESSEDBITSTREAMCONCEPTUALLY,EACHQUALITYLAYERMONOTONICALLYINCREASESTHEKNOWLEDGEOFSAMPLESMAGNITUDES,IEINCREASESTHEQUALITYOFTHERECONSTRUCTEDIMAGEFORMALLY,EBCOTISMADEOFTHREEMAINSTEPS,NAMELYSIGNIFICANCEPROPAGATIONSP,MAGNITUDEREFINEMENTMR,ANDCLEANUPCLEACHOFTHEABOVESTEPSCANRESORTTOFOURDECODINGPRIMITIVES,NAMELYZEROCODING,SIGNCODING,MAGNITUDEREFINEMENTCODING,ANDRUNLENGTHCODINGTHEBITPLANEVISITINGORDERFOLLOWSTHESEQUENCESPMRCLITISWORTHNOTICINGTHATEVERYSAMPLEOFAGIVENCODEBLOCKISPROCESSEDINJUSTONEOFTHETHREESTEPSASFARASCOMPUTATIONALCOMPLEXITYISCONCERNED,CLDEMANDSTHELARGESTEFFORTDURINGTHEDECODINGOFTHEMOSTSIGNIFICANTBITPLANESASSPSTEPSAREAPPLIED,ANINCREASINGNUMBEROFSAMPLESBECOMESIGNIFICANT,ANDAREINSERTEDINALISTOFMRREADYSAMPLESPROGRESSIVELY,THELOADREQUIREDBYMRSTEPSGROWS,MAKINGTHEDECODEREFFICIENCYDIRECTLYDEPENDENTONTHEMRANDCLOPTIMIZATIONLEVELDURINGTHEDEVELOPMENTOFTHEEBCOTDECODERBLOCK,PARTICULARCAREHASBEENPOSEDONTHEDESIGNOFAGILEDATASTRUCTURES,PARTICULARLYSUITEDTODSPOPTIMIZEDCCODEOFMRANDCLSTEPS33UNIFORMSCALARDEQUANTIZERACCORDINGTOL,THEQUANTIZATIONMETHODSUPPORTEDBYJPEG2000ISCALLEDSCALARUNIFORMUNIFORMSCALARDEQUANTIZATIONCANBESIMPLYACCOMPLISHEDBYMEANSOFASINGLEMULTIPLICATIONFOREACHWAVELETCOEFFICIENT34INVERSEWAVELETTRANSFORMTHEDISCRETEWAVELETTRANSFORMCANBEEVALUATEDBYMEANSOFACONVOLUTIONBASEDKERNEL,ORALIFTINGBASEDKERNEL,THISLATTERBEINGTHEDEFAULTTRANSFORMKERNELEMPLOYEDINJPEG2000ITHASBEENDEMONSTRATED4THATTHELIFTINGSCHEMEMAYRUNUPTOTWICEASFASTASCONVOLUTIONTHEWAVELETTRANSFORMHASTOBEPERFORMEDONBOTHIMAGEROWSANDCOLUMNS,INORDERTOOBTAINASEPARABLETWODIMENSIONALSUBBANDDECOMPOSITIONJPEG2000PERFORMSFIRSTTHECOLUMNWISE,ANDTHENTHEROWWISEFILTERINGTHEDEFAULTFILTERUSEDFORLOSSYCOMPRESSIONISTHEWELLKNOWNDB9,7SINCEITDOESNOTHAVERATIONALCOEFFICIENTS,PARTICULARCAREOUGHTTOBEPOSEDTOTHEEFFECTSOFFINITEPRECISIONREPRESENTATION5DUETOTHEUSEOFAFIXEDPOINTTITMS320C6201DSP,ADETAILEDSTUDYOFINTERNALDATAREPRESENTATIONHASBEENPERFORMEDEXPERIMENTALRESULTSSHOWSTHATEXCELLENTPERCEPTIVEQUALITYCANBEACHIEVEDRECURRINGTO9FRACTIONALBITSFORFILTERCOEFFICIENTSINORDERTOOPTIMIZETHEDYNAMICRANGEAROUNDZERO,ADCSHIFTISFORESEENBYTHESTANDARD,ASTHEDCCOMPONENTCOULDLEADTOANEXCESSIVEGROWTHOFTHEDYNAMICRANGEOFLOWPASSSUBBANDCOEFFICIENTSMOREOVER,THELOWPASSFILTERSCANKEEPTHESAMPLESINAFIXEDRANGE,PROVIDEDTHATAUNITARYDCFILTERGAINISGUARANTEEDTHEJOINTEFFECTOFDCCOMPONENTSUPPRESSIONANDUNITARYGAINENSURESTHATRANGEREQUIREMENTSAREFULFILLEDDURINGTHEWHOLEWAVELETTRANSFORM35ADAPTIVEREEDSOLOMONPACKETDETHEDEINTERLEAVINGRSDECODERHASBEENMAPPEDONTHEFPGADEVICEITISSPLITINTOTWOFUNCTIONALSUBBLOCKSTHEFIRSTISTHEDEINTERLEAVER,THESECONDISTHERSDECODERTHEFORMERCOLLECTSPACKETSRECEIVEDFROMCODING1332
      下載積分: 10 賞幣
      上傳時(shí)間:2024-03-14
      頁(yè)數(shù): 5
      10人已閱讀
      ( 4 星級(jí))
    • 簡(jiǎn)介:THEPREPARATIONANDWIDEFREQUENCYMICROWAVEABSORBINGPROPERTIESOFTRISUBSTITUTEDBISPHTHALONITRILE/FE3O4MAGNETICHYBRIDMICROSPHERESSHIHUADONG,MINGZHENXU,JUNJIWEI,XULINYANG,XIAOBOLIUNRESEARCHBRANCHOFFUNCTIONALMATERIALS,INSTITUTEOFMICROELECTRONICTHEMAGNETICLOSSWASENHANCEDOBVIOUSLYWITHTHEINCREASINGAMOUNTOFTPHADDITIONALLY,THEMICROWAVEABSORPTIONPROPERTIESWEREDETECTED,ANDTHERESULTSDEMONSTRATEDTHATTHESTRONGREFLECTIONLOSSRLANDMULTIMODALBANDSAPPEAREDINTHEWIDEFREQUENCYFORTHETPH/FE3O4MAGNETICHYBRIDMICROSPHERESWHENTHEMATCHINGTHICKNESSWAS50MM,THEEFFECTIVERLVALUESOF?31DB,?33DBAND?37DBWEREOBTAINEDINTHEWIDEMICROWAVEFREQUENCYRANGEFROM2GHZTO16GHZBYADJUSTINGTHECONTENTOFTPHTHEWIDEFREQUENCYMICROWAVEABSORPTIONPROPERTIES,TOGETHERWITHTHEREGULARSPHEREANDEXCELLENTMAGNETISM,ENABLETPH/FE3O4MAGNETICHYBRIDMICROSPHERESTOBEFURTHERAPPLIEDINTHEAREASOFFUNCTIONALMATERIALS2013ELSEVIERBVALLRIGHTSRESERVED1INTRODUCTIONMAGNETICHYBRIDMICROSPHERESAREANEWCLASSOFFUNCTIONALMATERIALSMADEOFMACROMOLECULARORGANICMATTERANDMAGNETITEFE3O4,WHICHPOSSESSTHEMAGNETICPROPERTIESASWELLASPROPERTIESOFORGANICMATTERITSNEWFUNCTIONSSHOWNBYTHECOMBINATIONOFTHEORGANICANDINORGANICMATTERSHAVEATTRACTEDMOREANDMOREATTENTIONWIDELYRESEARCHESANDAPPLICATIONHAVEBEENIMPLEMENTEDINTHEFIELDSOFBIOTECHNOLOGY,CHEMICAL,MILITARYSTEALTHMATERIAL,ENVIRONMENTALREMEDIATIONANDSOON1–4INRECENTYEARS,VARIOUSMETHODSHAVEBEENSUCCESSFULLYADOPTEDINPREPARINGFE3O4MICROSPHERES,SUCHASCORE–SHELLPROCESSES,EMULSIONPOLYMERIZATION,MINIEMULSIONPOLYMERIZATION,DISPERSIONPOLYMERIZATION,SUSPENSIONPOLYMERIZATION,ANDCROSSLINKING,ETCHOWEVER,OFALLTHESEMETHODS,THESTRUCTUREANDPERFORMANCEOFTHEPREPAREDMAGNETICHYBRIDMICROSPHERESSHOWITSPROSANDCONS5–9THEPROCESSOFTEDIOUSANDTIMECONSUMINGPREPARATION,BROADSIZEDISTRIBUTIONANDNOUNIFORMMAGNETITEFRACTIONARENOWTHENEWCHALLENGESTODEVELOPMAGNETICCOMPOSITESINADDITION,TOOBTAINIDEALABSORBINGMATERIALSWITHTHINTHICKNESSANDLOWDENSITYASWELLASBROADBANDMICROWAVEABSORPTION,FURTHERRESEARCHESARESTILLESSENTIALRECENTLY,AFACILEONESTEPSOLVENTTHERMALCRYSTALLIZATIONROUTETOPREPAREFE3O4MICROSPHERESHASBEENDEVELOPEDINOURLAB10,11THERESULTSINDICATEDTHATTHEFE3O4HYBRIDMICROSPHERESEXHIBITEDUNIFORMPARTICLESIZE,STABLEMAGNETISMANDSPECIALSTRONGMICROWAVEABSORPTIONPROPERTIES,WHICHEFFICIENTLYSOLVEDTHEABOVEPROBLEMSANDWASWIDELYAPPLIEDINMULTIFUNCTIONALMAGNETICMATERIALSACCORDINGTOTHELITERATURE,INTHEFORMATIONPROCESSOFPOLYMER/FE3O4MAGNETICHYBRIDMICROSPHERES,THEMICROSPHERESPROPERTIESDEPENDONTHETYPEANDMOLECULARSTRUCTUREOFTHEORGANICSPECIESDIFFERENTKINDSOFTHEPOLYMERCOMBINEDWITHFE3O4WILLPOSSESSDIFFERENTSTRUCTUREANDMORPHOLOGY,RESULTINGINTHEDISTINGUISHABLEMICROWAVEABSORPTIONPROPERTIESASREPORTED,THEPHTHALOCYANINEBASEDPOLYMER/FE3O4MAGNETICHYBRIDSCANCONTENTSLISTSAVAILABLEATSCIENCEDIRECTJOURNALHOMEPAGEWWWELSEVIERCOM/LOCATE/JMMMJOURNALOFMAGNETISMANDMAGNETICMATERIALS03048853/SEEFRONTMATTER2013ELSEVIERBVALLRIGHTSRESERVEDHTTP//DXDOIORG/101016/JJMMM201308038NCORRESPONDINGAUTHORTEL/FAXT8602883207326EMAILADDRESSLIUXBUESTCEDUCNXLIUJOURNALOFMAGNETISMANDMAGNETICMATERIALS349201415–2032MAGNETICPROPERTIESTHEHYSTERESISLOOPSFORTPH/FE3O4MAGNETICHYBRIDMICROSPHERESWITHVARIOUSCONTENTOFTPHAREINVESTIGATEDATROOMTEMPERATUREUSINGAVIBRATINGSAMPLEMAGNETOMETERVSM,ASSHOWNINFIG4THESATURATIONMAGNETIZATIONANDTHECOERCIVITYVALUESOFTHETHREESAMPLESARESUMMARIZEDINTABLE1THESAMPLESDEMONSTRATEBETTERMAGNETICPROPERTIESTHANTHOSEREPORTEDINLITERATURES17THESATURATIONMAGNETIZATIONVALUESDECREASEALONGWITHTHEINCREASINGAMOUNTOFTPH,BUTSTILLREACH5816EMUG?1THEREASONSHOULDBETHEEXISTENCEOFTHEORGANICMATTERINTHEFE3O4PARTICLESANDTHELOWERCRYSTALLIZATIONOFMAGNETITEINTHEHYBRIDMICROSPHERES17ANDS3HASLOWERSATURATIONMAGNETIZATIONTHANTHEOTHERTWOSAMPLESS1,S2,WHICHISGIVENRISETOTHEBIGGESTSPINUNORDEREDDEGREEANDTHEINCREASINGSURFACEAREAOFTHEMAGNETICHYBRIDMICROSPHERESITCANBESEENFROMTHETABLETHATTHECOERCIVITYINCREASESALONGWITHTHEINCREASINGAMOUNTOFTPHS1HASTHELOWESTCOERCIVITY,WHICHCANBEATTRIBUTEDTOTHEINCREASEDINTERPARTICLEDIPOLARINTERACTIONFROMTHEDECREASEDNANOPARTICLESPACEDISTANCEFORTHESINGLEDOMAINNANOPARTICLES1433MICROWAVEELECTROMAGNETICPROPERTIESITISWELLKNOWNTHATDIELECTRICCONSTANTANDPERMEABILITYARETHEINTRINSICPARAMETERSOFELECTROMAGNETICPROPERTYFORWAVEABSORBINGMATERIALBOTHDIELECTRICCONSTANTANDPERMEABILITYCANBEUSEDINTHEPLURALUNDERALTERNATINGMAGNETIC18INFIG5A,THEDIELECTRICLOSSCANBEEXPRESSEDASTHERATIOOFTHEIMAGINARYPARTΕ″ANDTHEREALPARTΕ′OFCOMPLEXPERMITTIVITYTHERANGEOFTHEDIELECTRICLOSSISBETWEEN001AND016WHENTHEFREQUENCYISLOWERTHAN7GHZ,THEDIELECTRICLOSSCURVESOFTHESAMPLESAREALLSMALLANDSIMILARANDTHEDIELECTRICLOSSMAXIMUMSOFS1,S2ANDS3APPEARATABOUT17GHZ,FIG2FTIRSPECTRAOFS1,S2ANDS3FIG1SEMIMAGESOFAPUREFE3O4,BS1,CS2ANDDS3SDONGETAL/JOURNALOFMAGNETISMANDMAGNETICMATERIALS349201415–2017
      下載積分: 10 賞幣
      上傳時(shí)間:2024-03-13
      頁(yè)數(shù): 6
      12人已閱讀
      ( 4 星級(jí))
    • 簡(jiǎn)介:COMPUTERAIDEDDESIGNAPPLICATIONS,VOL2,NOS14,2005,PP9510495ADAPTIVENCSIMULATIONFORMULTIAXISSOLIDMACHININGHONGTYAU1,LEESTSOU2ANDYUCTONG31NATIONALCHUNGCHENGUNIVERSITY,IMEHTYCCUEDUTW2NATIONALCHUNGCHENGUNIVERSITY,LSTSOUCADMECCUEDUTW3NATIONALCHUNGCHENGUNIVERSITY,PUMECCUEDUTWABSTRACTFORTHEMACHININGOFACOMPLICATEDSURFACE,ALARGEAMOUNTOFLINEARNCSEGMENTSAREUSUALLYGENERATEDTOAPPROXIMATETHESURFACEWITHPRECISIONIFINACCURATENCCODESARENOTDISCOVEREDUNTILTHEENDOFCUTTING,TIMEANDEXPENSIVEMATERIALWOULDBEWASTEDHOWEVER,ACCURATEANDVIEWINDEPENDENTVERIFICATIONOFMULTIAXISNCMACHININGISSTILLACHALLENGETHISPAPEREMPHASIZESTHEUSEOFADAPTIVEOCTREETODEVELOPARELIABLEMULTIAXISSIMULATIONPROCEDUREWHICHVERIFIESTHECUTTINGROUTEANDTHEWORKPIECEAPPEARANCEDURINGANDAFTERSIMULATIONVOXELMODELSWITHADAPTIVEOCTREEDATASTRUCTUREAREUSEDTOAPPROXIMATETHEMACHINEDWORKPIECEWITHSPECIFIEDRESOLUTIONIMPLICITFUNCTIONSAREUSEDTOREPRESENTVARIOUSCUTTERGEOMETRIESFORTHEEXAMINATIONOFCUTTERCONTACTPOINTSWITHSPEEDANDACCURACYITALLOWSAUSERTODOERRORANALYSISANDCOMPARISONBETWEENTHECUTTINGMODELANDTHEORIGINALCADMODELITCANALSOVERIFYTHEEXACTNESSOFNCCODESBEFOREMACHININGISCARRIEDOUTBYACNCMACHINEINORDERTOAVOIDWASTINGMATERIALANDTOIMPROVEMACHININGACCURACYKEYWORDSNCSIMULATION,SOLIDMACHINING,ADAPTIVEVOXELMODEL1INTRODUCTIONNCMACHININGISAFUNDAMENTALANDIMPORTANTMANUFACTURINGPROCESSFORTHEPRODUCTIONOFMECHANICALPARTSIDEALLY,ANNCMACHINEWOULDBERUNNINGINUNMANNEDMODETHEUSEOFNCSIMULATIONANDVERIFICATIONISESSENTIALIFPROGRAMSARETOBERUNWITHCONFIDENCEDURINGANUNMANNEDOPERATION1THEREFORE,ITISOFVITALIMPORTANCETOGUARANTEETHEEXACTNESSOFNCPATHSBEFOREEXECUTIONFROMLITERATURE,NCSIMULATIONCANMAINLYBEDIVIDEDINTOTHREEMAJORAPPROACHES7,DESCRIBEDASFOLLOWSTHEFIRSTKINDOFAPPROACHUSESDIRECTBOOLEANINTERSECTIONSOFSOLIDMODELSTOCALCULATETHEMATERIALREMOVALVOLUMESDURINGMACHINING2,3THISAPPROACHISTHEORETICALLYCAPABLEOFPROVIDINGACCURATENCSIMULATION,BUTTHEPROBLEMWITHUSINGTHESOLIDMODELINGAPPROACHISTHATITISCOMPUTATIONALLYEXPENSIVETHECOSTOFSIMULATIONUSINGCONSTRUCTIVESOLIDGEOMETRYISPROPORTIONALTOTHEFOURTHPOWEROFTHENUMBEROFTOOLMOVEMENTSON411THESECONDKINDOFAPPROACHUSESSPATIALPARTITIONINGREPRESENTATIONTOREPRESENTTHECUTTERANDTHEWORKPIECE48INTHISAPPROACH,ASOLIDOBJECTISDECOMPOSEDINTOACOLLECTIONOFBASICGEOMETRICELEMENTS,WHICHINCLUDEVOXELS4,5,DEXELS6,7,GBUFFERS8,ANDSOON,THUSSIMPLIFYINGTHEPROCESSESOFREGULARIZEDBOOLEANSETOPERATIONSTHETHIRDKINDOFAPPROACHUSESDISCRETEVECTORINTERSECTION911THISMETHODISBASEDONADISCRETIZATIONOFASURFACEINTOASETOFPOINTSCUTTINGISSIMULATEDBYCALCULATINGTHEINTERSECTIONOFVECTORSWHICHPASSTHROUGHTHESURFACEPOINTSWITHTOOLPATHENVELOPESDURINGMULTIAXISNCMACHINING,THECUTTINGTOOLFREQUENTLYROTATESSOTHATITISVERYDIFFICULTTOCALCULATEAWORKPIECEMODELTHATISVIEWDEPENDENTTHUS,INTHISPAPER,WEUSETHEVOXELDATASTRUCTURETOREPRESENTTHEWORKPIECEMODELBUTACCORDINGTOPASTLITERATURE,IFPRECISIONISNEEDED,ALARGENUMBEROFVOXELSMUSTBESETUPTOCARRYOUTBOOLEANSETOPERATIONSTHISCONSUMESMEMORYANDTIMETHUS,OURAPPROACHUSESTHEOCTREEDATASTRUCTURETOREPRESENTTHEWORKPIECEMODELTHEOCTREECANBEADAPTEDTOCREATEVOXELSWITHTHEDESIREDRESOLUTIONSTHATARENEEDEDWEUTILIZETHEOCTREETOQUICKLYSEARCHFORVOXELSWHICHHAVECONTACTWITHTHECUTTERHOWEVER,OURAPPROACHUSESANIMPLICITFUNCTIONTOREPRESENTTHECUTTINGTOOLBECAUSEACUTTERCANBEEASILYANDEXACTLYREPRESENTEDBYIMPLICITALGEBRAICEQUATIONS,ANDJUDGINGWHETHERTHECUTTERKEEPSINCONTACTWITHTHEWORKPIECEISALSOEASYTHUS,OURAPPROACHISRELIABLEANDPRECISETHECONTENTOFTHEPAPERISORGANIZEDASFOLLOWSSECTION2DISCUSSESTHEWORKPIECEREPRESENTATIONUSINGOCTREEBASEDVOXELMODESSECTION3PRESENTSTHEFORMULATIONOFIMPLICITFUNCTIONSUSEDTOREPRESENTTHEGEOMETRYOFVARIOUSCUTTERSCOMPUTERAIDEDDESIGNAPPLICATIONS,VOL2,NOS14,2005,PP9510497THISIMPLICITFUNCTIONISUSEDTODETERMINEWHETHERAVOXELISINSIDE,OUTSIDE,ORINTERSECTEDWITHTHECUTTERWITHOUTLOSINGANYACCURACYTHEJUDGMENTCANBEMADEBYINSERTINGTHECOORDINATESOFTHEVERTICESOFAVOXELINTOTHEIMPLICITFUNCTIONEQN2DESCRIBESTHERELATIONSHIPBETWEENAVERTEXANDTHECUTTER,WHICHISALSOILLUSTRATEDINFIG30LIEINSIDETHESURFACE,,0LIEONTHESURFACE0LIEOUTSIDETHESURFACEFXYZ?2WHERERTHECUTTERRADIUSLTHEDISTANCEMEASUREDFROMTHECENTERPOINTALONGTHECUTTERAXISFIG2FLATENDMILLANDTHEASSOCIATEDCOORDINATESYSTEMFIG3IMPLICITFUNCTIONUSEDTODETERMINETHEINTERIOROREXTERIOROFACUTTERBALLENDMILLSCANBEREPRESENTEDBYTHEUNIONOFACYLINDERANDASPHERE,ASSHOWNINFIG4ASSUMINGTHETOOLISPARALLELTOTHEZAXIS,ANDTHEORIGINOFTHECOORDINATESYSTEMISTRANSLATEDTOTHECENTEROFTHESPHERE,THEIMPLICITFUNCTIONOFABALLENDMILLCANBEDESCRIBEDAS{}2222222MAX,0,,ABSZLXYRIFZFXYZXYZROTHERWISE???≥?????3WHERERTHECUTTERRADIUSLTHEDISTANCEMEASUREDFROMTHECENTERPOINTALONGTHECUTTERAXIS
      下載積分: 10 賞幣
      上傳時(shí)間:2024-03-13
      頁(yè)數(shù): 10
      7人已閱讀
      ( 4 星級(jí))
    • 簡(jiǎn)介:HINDAWIPUBLISHINGCORPORATIONINTERNATIONALJOURNALOFAGRONOMYVOLUME2012,ARTICLEID543230,7PAGESDOI101155/2012/543230RESEARCHARTICLEIMPROVEMENTOFSOYBEANOILSOLVENTEXTRACTIONTHROUGHENZYMATICPRETREATMENTFVGRASSO,1PAMONTOYA,1CCCAMUSSO,1,2ANDBGMAROTO1,21FACULTADDECIENCIASEXACTAS,F′ISICASYNATURALES,UNIVERSIDADNACIONALDEC′ORDOBA,AVENUEVELEZSARSFIELD1200,5000C′ORDOBA,ARGENTINA2FACULTADDECIENCIASAGROPECUARIAS,UNIVERSIDADNACIONALDEC′ORDOBA,AVENUEVALPARA′ISOS/NO,5000C′ORDOBA,ARGENTINACORRESPONDENCESHOULDBEADDRESSEDTOFVGRASSO,FGRASSOAGROUNCEDUARRECEIVED5NOVEMBER2011REVISED14FEBRUARY2012ACCEPTED6MARCH2012ACADEMICEDITORBERTRANDMATTH¨AUSCOPYRIGHT?2012FVGRASSOETALTHISISANOPENACCESSARTICLEDISTRIBUTEDUNDERTHECREATIVECOMMONSATTRIBUTIONLICENSE,WHICHPERMITSUNRESTRICTEDUSE,DISTRIBUTION,ANDREPRODUCTIONINANYMEDIUM,PROVIDEDTHEORIGINALWORKISPROPERLYCITEDTHEPURPOSEOFTHISSTUDYISTOEVALUATEMULTIENZYMEHYDROLYSISASAPRETREATMENTOPTIONTOIMPROVESOYBEANOILSOLVENTEXTRACTIONANDITSEVENTUALADAPTATIONTOCONVENTIONALPROCESSESENZYMATICACTIONCAUSESTHEDEGRADATIONOFTHECELLSTRUCTURESTHATCONTAINOILIMPROVEMENTSINTERMSOFEXTRACTION,YIELD,ANDEXTRACTIONRATEAREEXPECTEDTOBEACHIEVEDSOYBEANFLAKESANDCOLLETSWEREUSEDASMATERIALSANDHEXANEWASUSEDASASOLVENTTEMPERATURE,PH,ANDINCUBATIONTIMEWEREOPTIMIZEDANDDIFFUSIONCOEFFICIENTSWEREESTIMATEDFOREACHSOLIDEXTRACTIONSWERECARRIEDOUTINACOLUMN,OILCONTENTWASDETERMINEDACCORDINGTOTIME,ANDAMATHEMATICALMODELWASDEVELOPEDTODESCRIBETHESYSTEMTHEOPTIMUMCONDITIONSOBTAINEDWEREPH54,38?C,AND97H,ANDPH58,44?C,AND58HOFTREATMENTFORFLAKESANDCOLLETS,RESPECTIVELYHYDROLYZEDSOLIDSEXHIBITEDAHIGHERYIELDDIFFUSIONCOEFFICIENTSWEREESTIMATEDBETWEEN10?11AND10?10THEHIGHESTDIFFUSIONCOEFFICIENTWASOBTAINEDFORHYDROLYZEDCOLLETS073GOIL/MLAND07GOIL/MLWEREOBTAINEDAT240SINACOLUMNFORCOLLETSANDFLAKES,RESPECTIVELYHYDROLYZEDSOLIDSEXHIBITEDAHIGHERYIELDTHEENZYMATICINCUBATIONACCELERATESTHEEXTRACTIONRATEANDALLOWSFORHIGHERYIELDTHEPROPOSEDMODELPROVEDTOBEAPPROPRIATE1INTRODUCTIONSEEDOILSREPRESENT70OFGLOBALOILPRODUCTION,OFWHICH30ISSOYBEANOILOILSEEDSARETHEMOSTIMPORTANTEXPORTITEMSINARGENTINA1INOILSEEDS,THEVACUOLESWITHINCELLSCONTAINOIL,ANDBOTHCELLWALLSANDVACUOLESHAVETOBEBROKENINORDERTOIMPROVESOLVENTEXTRACTIONTHEREFORE,THEPREPARATIONOFTHESEEDBEFORESOLVENTEXTRACTIONISCRITICALTOMAXIMIZEOILRECOVERYANALTERNATIVEPRETREATMENTTOFACILITATETHERELEASEOFOILFROMTHESEEDCOULDBEENZYMATICDEGRADATIONINTHISWAY,THEPARTIALHYDROLYSISOFSOYBEANSEEDCELLSTRUCTURESWITHAPPROPRIATEENZYMESWOULDINCREASEPERMEABILITY,WHICHWOULDINTURNINCREASEMASSTRANSFER2ANENZYMATICTREATMENTSTAGECOULDBEINCORPORATEDFORINDUSTRIALPURPOSESWITHOUTSIGNIFICANTCHANGESTOCONVENTIONALPROCESSESTHEOILRELEASEOBTAINEDUSINGTHISMETHODCOULDRESULTINAHIGHEREXTRACTIONYIELDAND/ORSMALLERQUANTITIESOFTHEORGANICSOLVENTSUSED3INSOLVENTEXTRACTION,PRETREATEDOILSEEDSPOROUSSOLIDMATRIXCOMEINTOCONTACTWITHAPURESOLVENTORASOLVENTMIXTUREMISCELLATOTRANSFERTHEOILFROMTHESOLIDMATRIXTOTHELIQUIDMEDIUMWHILETHEPRINCIPLEOFEXTRACTIONISRELATIVELYSIMPLE,ITISACOMPLEXMECHANISM4INORDERTODESCRIBETHISPROCESS,THEMASSTRANSFERPHENOMENAINVOLVEDANDTHEEVENTUALRESISTANCETOMASSTRANSFERINTHESOLIDPHASESOLIDSOYBEANANDINTHELIQUIDPHASEHEXANESHOULDBEANALYZEDTHISPROCESSINVOLVESSEVERALPHENOMENAOILISDIFFUSEDTHROUGHTHEINTERNALPORESTOTHESURFACEOFTHESOLIDINTERNALMASSTRANSPORTANDISTHENPASSEDTOTHEBULKLIQUIDBYMEANSOFACONVECTIVEMECHANISMPRODUCEDBYTHECONCENTRATIONDIFFERENCEBETWEENTHESOLUTIONOCCLUDEDINTHEPORESANDTHEBULKSOLUTIONEXTERNALTRANSPORTBECAUSETHEOILTOBEEXTRACTEDISCONTAINEDWITHINANINSOLUBLESOLIDNETWORKWITHOCCLUDEDMISCELLA,THEDIFFUSIONOCCURSMAINLYBETWEENTHEOCCLUDEDSOLUTIONANDTHESOLID,GREATLYAFFECTINGTHEEXTRACTIONRATESINCETHESOLIDMATRIXRESISTSDIFFUSIVETRANSPORT5INTERNATIONALJOURNALOFAGRONOMY3PROPOSEDBYMANYAUTHORS12–14,ANDCARR′INANDCRAPISTE4?C?TDEF?2C?X21WITHTHEFOLLOWINGINITIALANDBOUNDARYCONDITIONSFORANUNLIMITEDANDPERFECTLYAGITATEDVOLUMEOFBULKLIQUIDFORT0,CCO,FORT0,C0,INX?L,XL2THESOLUTIONTO1WASOBTAINEDFORPLATEANDSPHERE,ACCORDINGTOTHESOLIDTHATWASCONSIDEREDTHEFOLLOWINGWASOBTAINEDBYINTEGRATINGEACHSOLUTIONANDTAKINGINTOACCOUNTTHATTHESERIESOBTAINEDCONVERGERAPIDLYFORPLATEWITHTHICKNESS2L,QQ08Π2E?Π2DT/2L23FORSPHEREWITHRADIUSR,QQ06Π2E?Π2DEFT/R24BECAUSETHETRIGLYCERIDESPRESENTINVEGETABLEOILHAVEDIFFERENTMOLECULARWEIGHTSANDSTRUCTURES,ITISEASIERTOMEASURETHEAMOUNTOFOILINRELATIONTOSOLIDMASSTHEREFORE,THEC/COCONCENTRATIONRATIOWASTURNEDINTOAQ/Q0QUANTITYRATIOINBOTHEQUATIONS12EQUATIONS3AND4WERELINEARIZEDANDREPRESENTEDACCORDINGTOTIMETTHESLOPEOFBOTHLINESWASUSEDTOEVALUATETHEEFFECTIVEDIFFUSIONCOEFFICIENTSMATHEMATICALMODELFORCOLUMNEXTRACTIONTHEFIXEDBEDWASREGARDEDASASECTIONOFANEXTRACTIONCOLUMNTOWHICHASTEADYSTREAMOFHEXANE,QLO,ISSUPPLIEDANDFROMWHICHTHESAMEFLOWOFMISCELLA,QL,ISEXTRACTEDTHEMASSBALANCESFOREACHPHASEWERETHEFOLLOWINGSOLID?DCSDTKSAVS??CS?KEQCL?5LIQUIDDCLDT?QLCLVLKLAVL??CSKEQ?CL?6INTHEMASSBALANCEESTIMATION,ITWASASSUMEDTHATTHEBEDWASMADEUPOFPOROUSPARTICLESISOTROPICANDSPHERICALPARTICLESFORCOLLETSWITHANDWITHOUTENZYMATICPRETREATMENTANDFORFLAKESWITHENZYMATICTREATMENTTHEOILCONTENTINEACHOFTHESOLIDSISUNIFORMINALLPARTICLES,ANDTHEOILBEHAVESASASINGLECOMPONENT,SINCEITSTRIGLYCERIDESAREHIGHLYSOLUBLEINHEXANE12THESOLIDSCONTAINMACROPORESINWHICHTHEOILGLOBULESRESIDETHESOLVENTPENETRATESTHESEPORESANDDISSOLVESTHEOILINSTANTLY,FORMINGTHEMISCELLASTAGNANTPHASE4,15ANEQUILIBRIUMRELATIONSHIPISESTABLISHEDBETWEENTHEOILCONTENTINTHESTAGNANTPHASEINTHEPORESANDTHERESIDUALOILCONTENTINTHESOLIDTHEOILTRANSFEROCCURSFROMTHEPORESTOTHEMISCELLADUETOTHEOILCONCENTRATIONGRADIENTTHECOLUMNLENGTHPARTICLEDIAMETERRATIOISHIGHENOUGHTONEGLECTTHERADIALCONCENTRATIONGRADIENTTHEPOROSITIESOFTHEBEDANDPARTICLEAREUNIFORMANDCONSTANTTHROUGHOUTTHEEXTRACTIONPROCESSNOHEATOFMIXINGISPRODUCED,ANDTHETEMPERATUREISCONSTANTANDUNIFORMTHROUGHOUTTHEEXTRACTIONTHEEQUILIBRIUMRELATIONSHIPDETERMINEDEXPERIMENTALLYINCLUDESTHEEFFECTOFSOLIDMOISTURETHEVOLUMETRICFLOWISCONSTANTBECAUSETHEFLOWOFPUREHEXANESUPPLIEDINTOTHESYSTEMISEQUALTOTHEFLOWOFMISCELLAEXTRACTEDFROMTHESYSTEMTHEMASSTRANSFERCONSTANTSINTHELIQUIDWEREESTIMATEDUSINGTHEEMPIRICALCORRELATIONFORFIXEDBEDSPROPOSEDBYGEANKOPLIS6ANDTHEMASSTRANSFERCONSTANTSINTHESOLIDPHASEWEREESTIMATEDBYEQUALING5MASSBALANCEWITHTHEEQUATIONSTHATDESCRIBETHEDIFFUSIVEPHENOMENON,TAKINGINTOACCOUNTTHECORRECTIONSDUETOMATERIALPOROSITY16THESOLUTIONTO5AND6WASNUMERICALLYFOUNDUSINGMATLAB2008A3RESULTSANDDISCUSSIONOPTIMIZATIONOFENZYMATICTREATMENTTHEAMOUNTOFOILTHATCANBEEXTRACTEDFROMSOYBEANFLAKESUSINGTHESOXHLETMETHODIS16ONTHEDRYBASISDB,AND1854DBFORSOYBEANCOLLETSANINCREASEINYIELDISOBSERVEDFORALLEXPERIMENTALRUNSWITHENZYMATICPRETREATMENTSEETABLE2THERSMANALYSISENABLEDUSTOOBTAINTHEEXPERIMENTALCONDITIONSFORTHEENZYMATICAQUEOUSPRETREATMENT,THROUGHWHICHTHEMAXIMUMTHEORETICALYIELDINOILDBISOBTAINEDFOREACHTYPEOFSTARTINGMATERIALTHEANOVAANALYSISSEETABLE3WASUSEDTODEFINETHEPOLYNOMIALCOEFFICIENTSOFTHERESPONSEAFLAKESBOTHLINEARANDQUADRATICEFFECTSOFTEMPERATUREWERESIGNIFICANT,EXCEEDING95OFCONFIDENCELEVELINBOTHCASES,ANDSODIDTHEQUADRATICEFFECTOFINCUBATIONTIMEFORTHEPHVARIABLE,THEVARIATIONWASNOTSTATISTICALLYSIGNIFICANTP005ITCANALSOBEINFERREDTHATTHEREWERENOSIGNIFICANTEFFECTSFORINTERACTIONTERMSBETWEENVARIABLESTHEREFORE,THERESPONSEFUNCTIONWASDEFINEDASY27055–006T–368T2–004T2ERRORBCOLLETSTHEQUADRATICEFFECTSOFTEMPERATUREANDINCUBATIONPHWERESIGNIFICANT,EXCEEDING98OFCONFIDENCELEVELINBOTHCASES,ANDSODIDTHECROSSOVEREFFECTOFPHANDINCUBATIONTIMEFORTHEOTHERLINEARTERMS,THEVARIATIONWASNOTSTATISTICALLYSIGNIFICANTP005ITCANALSOBEINFERREDTHATTHEREWERENOSIGNIFICANTEFFECTSFORINTERACTIONTERMSBETWEENTHETEMPERATUREANDINCUBATIONTIMEVARIABLESTHEREFORE,THERESPONSEFUNCTIONWASDEFINEDASY265660186PHT–310T2–07274PH2ERRORASITCANBEOBSERVED,THEPVALUEINDICATESTHATTHEMODELISSIGNIFICANTFORALLCASESWITHMORETHAN98OFCONFIDENCEONTHEOTHERHAND,THEADEQUACYOFTHEQUADRATICMODELWITH98CONFIDENCE,A1347TOTALERRORFORFLAKESAND0864FORCOLLETS,ANDANONSIGNIFICANTLACKOFFITWITHACONFIDENCELEVELGREATERTHAN96FORTHETWOSTARTINGMATERIALSWASPROVED
      下載積分: 10 賞幣
      上傳時(shí)間:2024-03-13
      頁(yè)數(shù): 8
      14人已閱讀
      ( 4 星級(jí))
    • 簡(jiǎn)介:NATUREBIOTECHNOLOGYVOL18NOVEMBER2000HTTP//BIOTECHNATURECOM1151BIOPHARMACEUTICALSHAVETRADITIONALLYBEENPRODUCEDUSINGAVARIETYOFTRANSGENICSYSTEMS,INCLUDINGCULTUREDMAMMALIANCELLS,BACTERIA,ANDFUNGI1–3INTHEFUTURE,DEMANDFOREXISTINGBIOPHARMACEUTICALSEG,ERYTHROPOIETINTOTREATANEMIAANDINSULINTOTREATDIABETES,ASWELLASNEWTHERAPEUTICPROTEINSDISCOVEREDTHROUGHGENOMICSEFFORTS,ISEXPECTEDTORISECONSIDERABLY2ITISPRUDENT,THEREFORE,TOEVALUATEALTERNATIVETRANSGENICPRODUCTIONSYSTEMSANDDETERMINEHOWTHEFUTUREAVAILABILITYOFSAFERECOMBINANTBIOPHARMACEUTICALSCANBEENSUREDINACOSTEFFECTIVEMANNERPRODUCINGTHERAPEUTICPROTEINSINPLANTSHASMANYECONOMICANDQUALITATIVEBENEFITS,INCLUDINGREDUCEDHEALTHRISKSFROMPATHOGENCONTAMINATION,COMPARATIVELYHIGHYIELDS,ANDPRODUCTIONINSEEDSOROTHERSTORAGEORGANS2THECULTIVATION,HARVESTING,STORAGE,ANDPROCESSINGOFTRANSGENICCROPSWOULDALSOUSEANEXISTINGINFRASTRUCTUREANDREQUIRERELATIVELYLITTLECAPITALINVESTMENT2–4,MAKINGTHECOMMERCIALPRODUCTIONOFBIOPHARMACEUTICALSANEXCITINGPROSPECTPLANTSAREPOTENTIALLYACHEAPSOURCEOFRECOMBINANTPRODUCTS4–6KUSNADIETAL7HAVEESTIMATEDTHATTHECOSTOFPRODUCINGRECOMBINANTPROTEINSINPLANTSCOULDBE10TO50FOLDLOWERTHANPRODUCINGTHESAMEPROTEINBYESCHERICHIACOLIFERMENTATION,DEPENDINGONTHECROPMANYRECOMBINANTTHERAPEUTICPROTEINSAREPRODUCEDUSINGMAMMALIANEXPRESSIONSYSTEMSABIGADVANTAGEOFTHESE,ANDOFINSECTTISSUECULTURESYSTEMS,ISTHATTHEYCORRECTLYSYNTHESIZEANDPROCESSMAMMALIANPRODUCTSHOWEVER,PRODUCTYIELDSAREGENERALLYLOW,ANDTHEREQUIREMENTFORFETALBOVINESERUMINTHEGROWTHMEDIUMMAKESPRODUCTIONEXPENSIVE2INADDITION,CULTUREDMAMMALIANCELLSARESENSITIVETOSHEARFORCESTHATOCCURDURINGINDUSTRIALSCALECULTURE,ANDTOVARIATIONSINTEMPERATURE,PH,DISSOLVEDOXYGEN,ANDCERTAINMETABOLITESTHISMAKESITNECESSARYTOCONTROLCULTURECONDITIONSCAREFULLY,BECAUSEVARIATIONINCELLGROWTHCANAFFECTFERMENTATIONANDPRODUCTPURITYALTHOUGHBACTERIALANDFUNGALSYSTEMSAREMOREROBUST,THEYARENOTIDEALFORSYNTHESIZINGMANYMAMMALIANPROTEINSBECAUSEOFDIFFERENCESINMETABOLICPATHWAYS,PROTEINPROCESSING,CODONUSAGE,ANDTHEFORMATIONOFINCLUSIONBODIES3ALTHOUGHSOMEDIFFERENCESEXISTINPOSTTRANSLATIONPROCESSINGANDINCODONUSAGEBETWEENPLANTSANDMAMMALS,THESEAREFEWCOMPAREDWITHDIFFERENCESBETWEENMAMMALSANDMICROORGANISMS2,8,9WHEREDIFFERENCESINPROCESSINGDOREPRESENTAPROBLEM,ITMAYBEPOSSIBLETOENGINEERPLANTSWITHALTEREDPROTEINMATURATIONPATHWAYS3,10BIOPHARMACEUTICALSPRODUCEDINCELLCULTURESYSTEMSHAVETOBEPURIFIEDFROMTHECULTURESUPERNATANT,ANEXPENSIVEPROCESSPLANTSCANBEMADETOSTOREPROTEINSINSEEDENDOSPERM,FROMWHERETHEYCANBEEASILYEXTRACTED2,11NEVERTHELESS,PURIFICATIONISPOTENTIALLYANEXPENSIVESTEP,ANDVARIOUSMETHODSAREBEINGDEVELOPEDTOOVERCOMETHISPROBLEM,INCLUDINGTHEEXPRESSIONOFPROTEINSASFUSIONSWITHOLEOSINSEEDISCUSSIONBELOWFORHIRUDIN4–6ANALTERNATIVEAPPROACHISTOCOVERTHECOSTSOFPURIFICATIONWITHTHEINCOMEFROMTHEEXTRACTIONOFCONVENTIONALPRODUCTS,SUCHASMEAL,OIL,ORSTARCHTHECOSTSOFISOLATINGHUMANSERUMALBUMINFROMSTARCHPOTATOES,FOREXAMPLE,COULDBELARGELYCOVEREDBYCONCOMITANTSTARCHPRODUCTION4,5,12INADDITION,PURIFICATIONMAYNOTALWAYSBENECESSARY,FOREXAMPLE,INTHECASEOFEDIBLEVACCINESPLANTDERIVEDPRODUCTS,WHETHERPURIFIEDORNOT,ARELESSLIKELYTOBECONTAMINATEDWITHHUMANPATHOGENICMICROORGANISMSTHANTHOSEDERIVEDFROMANIMALCELLS,BECAUSEPLANTSDON’TACTASHOSTSFORHUMANINFECTIOUSAGENTS13INTHISSHORTREVIEW,WEOUTLINETHEMAINTYPESOFPLANTEXPRESSIONSYSTEMSEMPLOYEDFORTHEAGRICULTURALPRODUCTIONOFBIOPHARMACEUTICALSANDPROVIDEANOVERVIEWOFTHETYPESOFVACCINE,ANTIBODY,ANDTHERAPEUTICPROTEINPRODUCTSCURRENTLYUNDERDEVELOPMENTFORAREVIEWONFOREIGNPROTEINPRODUCTIONINPLANTTISSUECULTURE,SEEREF14AGRICULTURALPRODUCTIONSYSTEMSTWOTRANSFORMATIONAPPROACHESARECOMMONLYUSEDTOPRODUCERECOMBINANTPHARMACEUTICALSINPLANTS8,10,15–17INTHEFIRST,STABLYTRANSGENICPLANTSASFACTORIESFORBIOPHARMACEUTICALSGLYNISGIDDINGS,GORDONALLISON,DOUGLASBROOKS,ANDADRIANCARTERINSTITUTEOFBIOLOGICALSCIENCES,UNIVERSITYOFWALES,ABERYSTWYTH,CLEDWYNBUILDING,ABERYSTWYTHCEREDIGIONSY233DD,UKCORRESPONDINGAUTHORGDGABERACUKRECEIVED12NOVEMBER1999ACCEPTED11AUGUST2000PLANTSHAVECONSIDERABLEPOTENTIALFORTHEPRODUCTIONOFBIOPHARMACEUTICALPROTEINSANDPEPTIDESBECAUSETHEYAREEASILYTRANSFORMEDANDPROVIDEACHEAPSOURCEOFPROTEINSEVERALBIOTECHNOLOGYCOMPANIESARENOWACTIVELYDEVELOPING,FIELDTESTING,ANDPATENTINGPLANTEXPRESSIONSYSTEMS,WHILECLINICALTRIALSAREPROCEEDINGONTHEFIRSTBIOPHARMACEUTICALSDERIVEDFROMTHEMONETRANSGENICPLANTDERIVEDBIOPHARMACEUTICAL,HIRUDIN,ISNOWBEINGCOMMERCIALLYPRODUCEDINCANADAFORTHEFIRSTTIMEPRODUCTPURIFICATIONISPOTENTIALLYANEXPENSIVEPROCESS,ANDVARIOUSMETHODSARECURRENTLYBEINGDEVELOPEDTOOVERCOMETHISPROBLEM,INCLUDINGOLEOSINFUSIONTECHNOLOGY,WHICHALLOWSEXTRACTIONWITHOILBODIESINSOMECASES,DELIVERYOFABIOPHARMACEUTICALPRODUCTBYDIRECTINGESTIONOFTHEMODIFIEDPLANTPOTENTIALLYREMOVESTHENEEDFORPURIFICATIONSUCHBIOPHARMACEUTICALSANDEDIBLEVACCINESCANBESTOREDANDDISTRIBUTEDASSEEDS,TUBERS,ORFRUITS,MAKINGIMMUNIZATIONPROGRAMSINDEVELOPINGCOUNTRIESCHEAPERANDPOTENTIALLYEASIERTOADMINISTERSOMEOFTHEMOSTEXPENSIVEBIOPHARMACEUTICALSOFRESTRICTEDAVAILABILITY,SUCHASGLUCOCEREBROSIDASE,COULDBECOMEMUCHCHEAPERANDMOREPLENTIFULTHROUGHPRODUCTIONINTRANSGENICPLANTSKEYWORDSBIOPHARMACEUTICALS,GMCROPS,EDIBLEVACCINE,ANTIBODIES,PRODUCTIONSYSTEMSREVIEW?2000NATUREAMERICAINCHTTP//BIOTECHNATURECOM?2000NATUREAMERICAINCHTTP//BIOTECHNATURECOMNATUREBIOTECHNOLOGYVOL18NOVEMBER2000HTTP//BIOTECHNATURECOM1153ONEIMPORTANTTARGETFORCURRENTVACCINEEFFORTSISHEPATITISB,AVIRUSRESPONSIBLEFORTHEMAJORITYOFPERSISTENTVIREMIAINHUMANSTHATCANCAUSECHRONICLIVERDISEASETHEFIRSTCOMMERCIALLYAVAILABLERECOMBINANTVACCINEWASDEVELOPEDINYEASTAFTERCONCERNSABOUTTHESAFETYOFSERUMDERIVEDANTIGENSINMANYPLACES,EXPENSE,TOGETHERWITHALACKOFFACILITIESEG,REFRIGERATIONINSTALLATIONSHASPROHIBITEDTHEUSEOFRECOMBINANTVACCINESIN1992,THEWORLDHEALTHORGANIZATIONGENEVAANDACONSORTIUMOFOTHERPHILANTHROPICORGANIZATIONSBEGANTHECHILDREN’SVACCINEINITIATIVEASPARTOFTHISEFFORT,THANAVALAETAL43INITIALLYDEVELOPEDTRANSGENICTOBACCO,ANDTHENPOTATOES,THATEXPRESSHEPATITISBSURFACEANTIGENHBSAG43,45BYMAXIMIZINGTHEIMMUNOGENICITYOFUNTREATEDEDIBLEPLANTTISSUES,THEGROUPHOPESTOPRODUCEVACCINESFORDEVELOPINGCOUNTRIESTHEYHAVERECENTLYSHOWNTHATHBSAGTRANSGENICPOTATOESADMINISTEREDORALLYTOMICECANELICITHUMORALIMMUNERESPONSES45ULTIMATELY,ATTENTIONWILLFOCUSONTHEMODIFICATIONOFBANANAS,WHICHAREGROWNEXTENSIVELYTHROUGHOUTTHEDEVELOPINGWORLDAND,INCONTRASTTOPOTATOES,CANBEEATENRAW23BANANAVACCINES,DELIVEREDASAPURéE,WOULDCOSTJUSTASMALLFRACTIONOFTHEPRICEOFTRADITIONALVACCINESINTHEFUTURE,BANANAVACCINESCOULDBEPRODUCEDAGAINSTARANGEOFDISEASES,INCLUDINGMEASLES,POLIO,DIPHTHERIA,YELLOWFEVER,ANDCERTAINTYPESOFVIRALDIARRHEAANTIBODIESTHEALTERNATIVETOINDUCINGTHEIMMUNESYSTEMTOPRODUCEANTIBODIESISTODELIVERTHEMDIRECTLYALTHOUGHTHETHERAPEUTICPOTENTIALOFANTIBODIESHASLONGBEENRECOGNIZEDEG,FORINDIVIDUALSNEEDINGSHORTTERMPROTECTIONAGAINSTINFECTIOUSAGENTS,DIFFICULTIESASSOCIATEDWITHTHEIRPRODUCTIONHAVELIMITEDCLINICALUSE8,40IN1989,HIATTETAL17FIRSTDEMONSTRATEDTHATFUNCTIONALANTIBODIESCOULDBEPRODUCEDINTRANSGENICPLANTSSINCETHEN,ACONSIDERABLEAMOUNTOFEFFORTHASBEENINVESTEDINDEVELOPINGPLANTSFORANTIBODYOR“PLANTIBODY”PRODUCTION8,9,11,17,31,33,40,42RECOMBINANTANTIBODIESCANBETARGETEDTOSEEDSANDTUBERS9,11,31,33,ANDEVENTUALLYITSHOULDBEPOSSIBLETOSTORE,TRANSPORT,ANDADMINISTERANTIBODIESINSUCHPLANTTISSUES,WHICHWOULDBEADVANTAGEOUSFORIMMUNIZATIONPROGRAMSINDEVELOPINGCOUNTRIES9,33,47MANYOFTHEANTIBODIESPRODUCEDINTRANSGENICPLANTSHAVEAPPLICATIONSFORHUMANANDANIMALHEALTHCARE8,33,40,48TABLE2,ANDTHEYMAYALSOPROVEUSEFULFOROTHERAPPLICATIONSSUCHASBIOREMEDIATION9RECOMBINANTANTIBODIESINCLUDEFULLYASSEMBLEDWHOLEIMMUNOGLOBULINS17,48,ANTIGENBINDINGFRAGMENTSOFIMMUNOGLOBULINS,ANDSYNTHETICSINGLECHAINVARIABLEFRAGMENTGENEFUSIONSSCFV9,31SINGLECHAINFVANTIBODIESAREENCODEDBYANARTIFICIALGENEMADEBYJOININGTOGETHERLIGHTANDHEAVYCHAINVARIABLESEQUENCES9,11,31,33PLANTIBODIESCOULDBEOFPARTICULARBENEFITFORTOPICALIMMUNOTHERAPY8,16,40PASSIVEIMMUNIZATIONOFTHEMUCOSALSITESCOULDBEEFFECTIVEAGAINSTBACTERIA,FUNGI,ANDVIRUSES8PLANTIBODIESAGAINSTCELLSURFACEANTIGENSOFSTREPTOCOCCUSMUTANSHAVEBEENSHOWNTOREDUCETOOTHDECAYINANIMALMODELSANDHUMANS44,45REPEATEDLARGEDOSESOFANTIBODYAREREQUIREDFORTOPICALPASSIVEIMMUNOTHERAPY,ANDTRANSGENICPLANTSCOULDBEUSEFULFORPRODUCINGSUCHLARGEQUANTITIES40FURTHERMORE,ITHASBEENSHOWNTHATTRANSGENICPLANTSCANBEGENERATEDTHATWILLEFFICIENTLYASSEMBLECOMPLEXSECRETORYANTIBODIES,SOMETHINGPREVIOUSLYTHOUGHTDIFFICULTTOACHIEVEINPLANTS8,40THISWASACCOMPLISHEDBYCONSTRUCTINGTOBACCOPLANTSEXPRESSINGFOURTRANSGENESTHROUGHCROSSINGOFPLANTSTRANSFORMEDWITHSINGLETRANSGENESGENESTACKING17THERESULTINGQUADRUPLETRANSGENICSEFFICIENTLYASSEMBLESECRETORYIMMUNOGLOBULINASIGA,THEPREDOMINANTIMMUNOGLOBULINTHATPROTECTSAGAINSTMICROBIALINFECTIONATMUCOSALSITES8,40SECRETORYIGAISBOTHMOREEFFICIENTATBINDINGANTIGENSANDMORESTABLETHANTHEPLANTIBODIESINITIALLYPRODUCED,BEINGMORERESISTANTTOPROTEOLYSISBECAUSEOFTHISINCREASEDSTABILITY,TREATMENTOFALLMUCOSALSITESMAYBEPOSSIBLE,INCLUDINGTHEGASTROINTESTINALTRACT8THEUSEOFEDIBLEPLANTSFORTHISISOBVIOUSLYANATTRACTIVEPOSSIBILITY40THEABILITYTOASSEMBLEIMMUNOGLOBULINSISAMAJORADVANTAGETHATPLANTSHAVEOVERBACTERIALEXPRESSIONSYSTEMSBIOPHARMACEUTICALSTRANSGENICPLANTSHAVEBEENCONSTRUCTEDTHATEXPRESSPROTEINSSUCHASENKEPHALINS26,ΑINTERFERON2,24,HUMANSERUMALBUMIN12,ANDTWOOFTHEMOSTEXPENSIVEDRUGSGLUCOCEREBROSIDASE13,41ANDGRANULOCYTE–MACROPHAGECOLONYSTIMULATINGFACTOR2,13,41TABLE3APPLIEDPHYTOLOGICSAPISACRAMENTO,CAHASMODIFIEDRICEPLANTSTOPRODUCEHUMANΑ1ANTITRYPSIN,APROTEINOFTHERAPEUTICPOTENTIALINCYSTICFIBROSIS,LIVERDISEASE,ANDHEMORRHAGESTRIALSOFΑ1ANTITRYPSINTRANSGENICRICECOMMENCEDIN1998,WITHPROTEINEXTRACTEDFROMMALTEDGRAINAPIHOPESTOHAVEREGULATORYAPPROVALFORTRANSGENICPLANTMEDICALPRODUCTSBY2004GAUCHER’SDISEASEISARECESSIVELYINHERITEDLYSOSOMALSTORAGEDISORDERRESULTINGFROMDEFICIENCIESOFLYSOSOMALHYDROLASEGLUCOCEREBROSIDASEENZYME13ADRUGDEVELOPEDFROMENZYMEPURIFIEDFROMHUMANPLACENTASISHIGHLYEFFECTIVEATREDUCINGCLINICALSYMPTOMSHOWEVER,10–12TONS/YEAROFPLACENTASAREREQUIREDTOPRODUCEENOUGHGLUCOCEREBROSIDASEFORTHEAVERAGETYPEIGAUCHER’SPATIENT,MAKINGITONEOFTHEWORLD’SMOSTEXPENSIVEDRUGS41ARECENTSWITCHTOPRODUCTIONINMAMMALIANCELLCULTURESYSTEMSHASREDUCEDTHISCOST,BUTDIDN’TREMOVETHEDRUGFROMTHE“MOSTEXPENSIVE”LEAGUEGLUCOCEREBROSIDASEPRODUCTIONINTRANSGENICTOBACCO13,41WASPATENTEDBYCRAM
      下載積分: 10 賞幣
      上傳時(shí)間:2024-03-13
      頁(yè)數(shù): 5
      14人已閱讀
      ( 4 星級(jí))
    • 簡(jiǎn)介:NEUROLOGICALREVIEWPREVENTIVEANTIBIOTICSFORINFECTIONSINACUTESTROKEASYSTEMATICREVIEWANDMETAANALYSISDIEDERIKVANDEBEEK,MD,PHDEELCOFMWIJDICKS,MD,PHDFREDERIQUEHVERMEIJ,MDROBJDEHAAN,PHDJANMPRINS,MD,PHDLODEWIJKSPANJAARD,MD,PHDDIEDERIKWJDIPPEL,MD,PHDPAULJNEDERKOORN,MD,PHDOBJECTIVETOPROVIDEASYSTEMATICOVERVIEWANDMETAANALYSISOFRANDOMIZEDCLINICALTRIALSEVALUATINGPREVENTIVEANTIBIOTICSINPATIENTSWITHACUTESTROKEDATASOURCESTHEMEDLINE1966FEBRUARY2009ANDCOCHRANEDATABASESANDREFERENCELISTSOFRETRIEVEDARTICLESSTUDYSELECTIONRANDOMIZEDCONTROLLEDTRIALSONPREVENTIVEANTIBIOTICTREATMENTINSTROKEFORINCLUSION,ATLEASTCASEFATALITYORINFECTIONRATEHADTOBERECORDEDDATAEXTRACTIONEACHSTUDYWASSCOREDFORMETHODOLOGICALKEYISSUESANDAPPRAISEDBYTHEJADADSCALEWEEXTRACTEDTHEDATAUSINGAPREDETERMINEDPROTOCOLANDINCLUDEDALLPATIENTSWHOWERERANDOMIZEDORWHOSTARTEDTHERAPYINANINTENTTOTREATANALYSISDATASYNTHESISWEIDENTIFIED4RANDOMIZEDCLINICALTRIALSINCLUDING426PATIENTS94HADISCHEMICSTROKESTUDYINTERVENTIONSWEREFLUOROQUINOLONESIN2ANDTETRACYCLINEORACOMBINATIONOF?LACTAMANTIBIOTICWITH?LACTAMASEINHIBITORIN1THERAPYWASSTARTEDWITHIN24HOURSOFSTROKEONSETDURATIONOFTHERAPYVARIEDBETWEEN3AND5DAYSTHEMETHODOLOGICALQUALITYRANGEDFROM2TO5ONTHEJADADSCALE,ANDSTUDIESWERESUBJECTTOPOTENTIALBIASTHEPROPORTIONOFPATIENTSWITHINFECTIONWASSIGNIFICANTLYSMALLERINTHEANTIBIOTICGROUPTHANINTHEPLACEBO/CONTROLGROUP32OF136235VS53OF139381PATIENTSTHEPOOLEDODDSRATIOFORINFECTIONWAS04495CONFIDENCEINTERVAL,023086TENOF210PATIENTS48INTHEANTIBIOTICGROUPDIED,COMPAREDWITH13OF21660INTHEPLACEBO/CONTROLGROUPTHEPOOLEDODDSRATIOFORMORTALITYWAS06395CONFIDENCEINTERVAL,022178NOMAJORHARMORTOXICITYWASREPORTEDCONCLUSIONSINADULTSWITHACUTESTROKE,PREVENTIVEANTIBIOTICSREDUCEDTHERISKOFINFECTION,BUTDIDNOTREDUCEMORTALITYTHEOBSERVEDEFFECTWARRANTSEVALUATIONOFPREVENTIVEANTIBIOTICSINLARGESTROKETRIALSARCHNEUROL200966910761081INFECTIONISACOMMONCOMPLICATIONINTHEACUTEPHASEAFTERSTROKEANDHASBEENDESCRIBEDINUPTO40OFPATIENTS1THEMOSTCOMMONINFECTIONAFTERACUTESTROKEISPNEUMONIA,WITHREPORTEDRATESUPTO30PNEUMONIAISANEARLYINFECTIONABOUTHALFOFTHECASESOCCURWITHINTHEFIRST48HOURSAFTERSTROKEONSETANDALMOSTALLWITHINTHEFIRSTWEEK1THEMORTALITYANDMORBIDITYASSOCIATEDWITHPNEUMONIAISHIGHINACOMMUNITYBASEDSTUDYINCLUDING14293PATIENTSWITHSTROKE,2PNEUMONIAWASASSOCIATEDWITHARELATIVERISKOF30FORMORTALITY95CONFIDENCEINTERVALCI,2437WHENADJUSTEDFORADMISSIONSEVERITYANDPROPENSITYFORPNEUMONIAINTHEUNITEDSTATES,THEANNUALCOSTOFPNEUMONIAASACOMPLICATIONAFTERACUTESTROKEHASBEENESTIMATEDTOBE459MILLION3OVERTHELAST3YEARS,SEVERALSTUDIESHAVEEVALUATEDPREVENTIVEUSEOFANTIBIOTICSINPATIENTSWITHACUTESTROKE,WITHCONFLICTINGRESULTS1CURRENTGUIDELINESONACUTESTROKEMANAGEMENTSTATETHATPREVENTIVEADMINISTRATIONOFANTIBIOTICSISNOTINDICATEDBECAUSETHISTREATMENTHASNOTBEENPROVENEFFECTIVE4HEREINWEPROVIDEASYSTEMATICOVERVIEWOFALLRANDOMIZEDCLINICALTRIALSEVALUATINGPREVENTIVEANTIBIOTICSINPATIENTSWITHACUTESTROKEMETHODSWESELECTEDSTUDIESONPREVENTIVEANTIBIOTICTREATMENTINACUTESTROKEELIGIBLEPATIENTSWEREADULTSPREDEFINEDASAGED16YEARSOROLDERWITHACUTESTROKE,RANDOMIZEDFORORALORINTRAVENOUSANTIBIOTICSOFANYTYPEORAPLACEBOORCONTROLGROUPEACHSTUDYWASSCOREDFORMETHODOLOGICALKEYISSUES,SUCHASINCLUSIONANDEXCLUSIONCRITERIA,TREATMENTINTERVENAUTHORAFFILIATIONSDEPARTMENTSOFNEUROLOGYDRSVANDEBEEKANDNEDERKOOM,CLINICALEPIDEMIOLOGYANDBIOSTATISTICSDRDEHAAN,INFECTIOUSDISEASESDRPRINS,ANDMEDICALMICROBIOLOGYDRSPANJAARD,CENTEROFINFECTIONANDIMMUNITYAMSTERDAMCINIMA,ACADEMICMEDICALCENTER,AMSTERDAM,THENETHERLANDSDEPARTMENTOFNEUROLOGY,DIVISIONOFCRITICALCARENEUROLOGY,MAYOCLINIC,ROCHESTER,MINNESOTADRWIJDICKSANDTHEDEPARTMENTOFNEUROLOGYDRSVERMEIJANDDIPPEL,ERASMUSUNIVERSITYMEDICALCENTER,ROTTERDAM,THENETHERLANDSREPRINTEDARCHNEUROL/VOL66NO9,SEP2009WWWARCHNEUROLCOM1076?2009AMERICANMEDICALASSOCIATIONALLRIGHTSRESERVEDDOWNLOADEDFROMHTTP//ARCHNEURJAMANETWORKCOM/BYAUNIVERSITYOFAMSTERDAMUSERON08/16/2013CRITERIAORINABILITYTOCOMPLETETHETREATMENTPROTOCOLPATIENTSWHOMETELIGIBILITYCRITERIABUTWEREEXCLUDEDAFTERTHERANDOMIZATIONPROCESSWEREINCLUDEDINTHECURRENTANALYSISONESTUDYDIDNOTDESCRIBEWITHDRAWALS10INTHISTRIAL,PATIENTSWITHALIFEEXPECTANCYOFFEWERTHAN90DAYSWEREEXCLUDED,WHICHRESULTEDINANOVERALLMORTALITYRATEOF010ONESTUDYDIDNOTHAVEABLINDEDOUTCOMEASSESSMENT8THISWASALSOTHESTUDYTHATUSEDQUASIRANDOMIZATION8THEPRIMARYOUTCOMEMEASURESWERETHEINFECTIONRATEINTHE2STUDIESANDTHEPROPORTIONOFPATIENTSWITHFEVERDURINGADMISSIONIN1STUDYTHEDEFINITIONSUSEDFORINFECTIONDIFFEREDSUBSTANTIALLYBETWEENSTUDIESTHECRITERIAFORINFECTIONAREPRESENTEDINTABLE2ONESTUDYADHEREDTOTHEOFFICIALCRITERIAOFTHEUSCENTERSFORDISEASECONTROLANDPREVENTION,BUTUSEDHEAVILYMODIFIEDCRITERIA11INFECTIONRATESWERENOTEVALUATEDINALLSTUDIESONESTUDYFOCUSEDONTHENEUROPROTECTIVEEFFECTSOFMINOCYCLINEANDDIDNOTEVALUATEINFECTIONRATES8THEPRIMARYOUTCOMEINTHISTRIALWASTHEDIFFERENCEBETWEENTHENIHSSSCORESOFINDIVIDUALPATIENTSATTHEBASELINEANDONDAY90OVERALL,SECONDARYOUTCOMESWERESCORESONTHEMODIFIEDRANKIN,6,10NIHSS,6,8ANDBARTELINDEX6,9THESESECONDARYOUTCOMESWEREASSESSED90DAYSAFTERRANDOMIZATIONCASEFATALITYRATESWEREREPORTEDINALLSTUDIESSAMPLESIZECALCULATIONSWEREPERFORMEDIN2STUDIES6,9ONESTUDYWASPOWEREDTODETECTSIGNIFICANTEFFECTONTHERATEOFINFECTIONBASEDONTHEASSUMPTIONOFAREDUCTIONFROM30TO15OR,041,REQUIRING480PATIENTS6THISSTUDYWASTERMINATEDAFTERINCLUSIONOF130PATIENTSBECAUSENOEFFECTWASTOBEEXPECTEDWITHINCLUSIONOFALL480PATIENTSATTHEMOMENTOFTERMINATIONOFENROLLMENT,THEPROPORTIONOFPATIENTSWITHINFECTIONWAS17INPLACEBOGROUPAND18INTHELEVOFLOXACINGROUP6EFFICACYOFANTIBIOTICPROPHYLAXISRESULTSOFTHESTUDIESARENOTEDINTABLE3THESTUDYPOPULATIONSMAINLYINCLUDEDPATIENTSWITHISCHEMICSTROKE410OF436INCLUDEDPATIENTS94ONESTUDYALSOINCLUDEDPATIENTSWITHHEMORRHAGEDEEPHEMATOMA,17LOBARHEMATOMA,96THEOVERALLNUMBEROFPARTICIPANTSWITHINFECTIONWASSIGNIFICANTLYSMALLERINTHEANTIBIOTICGROUPTHANINTHEPLACEBOORCONTROLGROUP32OF136235VS53OF139381PATIENTSTABLE3THENUMBERNEEDEDTOTREATTOPREVENTINFECTIONWAS7THEPOOLEDORFORINFECTIONWAS04495CI,023086FIGUREINFECTIONSWEREPNEUMONIAN61,URINARYTRACTINFECTIONSN21,BRONCHITISN5,ANDOTHERSN5THEINFECTIONSTHATWEREPREVENTEDBYANTIBIOTICTHERAPYWERETHOSETHATOCCURREDMOSTFREQUENTLY,PNEUMONIAANDURINARYTRACTINFECTIONSTENOF21048PATIENTSWHOWERETREATEDWITHANTIBIOTICSDIED,COMPAREDWITH13OF21660RECEIVINGPLACEBOORNOTREATMENTTABLE3THENUMBERNEEDEDTOTREATTOPREVENTDEATHWAS83THEPOOLEDORFORMORTALITYWAS06395CI,022178FIGURECASEFATALITYRATESVARIEDBETWEENSTUDIESFROM0TO7TWOSTUDIESHADPOSITIVERESULTSONTHEIRPRIMARYOUTCOME1ONIMPROVEMENTOFBASELINENIHSSSCOREMEANSD,1619VS6538P?001AND1ONOCCURRENCEOFFEVERP?058,10IN1STUDY,THERESULTOFPRIMARYANALYSISWASPOSITIVEFORTHEPERPROTOCOLANALYSISONLYOCCURRENCEOFINFECTIONS,6OF3517VS13OF3142PATIENTSP039IN1STUDY,THEPROPORTIONOFPATIENTSWITHFAVORABLENEUROLOGICALOUTCOMEWASSTATISTICALLYSIGNIFICANTLYREDUCEDANDNOEFFECTWASOBSERVEDONMORTALITY8THERATEOFINFECTIONWASNOTEVALUATEDINTHISSTUDYSAFETYOFANTIBIOTICPROPHYLAXISADVERSEEVENTSWEREDESCRIBEDIN3ARTICLESANTIBIOTICTREATMENTWASNOTASSOCIATEDWITHANYSIDEEFFECTSIN2STUDIESTHESTUDYEVALUATINGMEZLOCILLINPLUSSULBACTAMDESCRIBEDEXANTHEMAANDELEVATEDLIVERENZYMESEACHIN1PATIENT10ANTIBIOTICSUSCEPTIBILITYTESTINGOFESCHERICHIACOLIISOLATESWASPERFORMEDIN1STUDY9NODIFFERENCEWASFOUNDINANTIBIOTICRESISTANCEPATTERNSBETWEENBACTERIALISOLATESFROMPATIENTSINTHEMOXIFLOXACINANDPLACEBOGROUPSTABLE2DEFINITIONSUSEDFORINFECTIONSOURCEDEFINITIONCHAMORROETAL6TEMPERATURE?375°CIN2DETERMINATIONS?378°CINASINGLEDETERMINATIONINPATIENTSWITHSUGGESTIVESYMPTOMSWHITEBLOODCELLCOUNT?11000/MLOR?4000/MLPULMONARYINFILTRATEONCHESTXRAYSORCULTURESPOSITIVEFORAPATHOGENLAMPLETAL8NOTEVALUATEDHARMSETAL9APNEUMONIA,?1OFABNORMALRESPIRATORYEXAMINATIONORPULMONARYINFILTRATESINCHESTXRAYS,ORPRODUCTIVECOUGHWITHPURULENTSPUTUM,MICROBIOLOGICALCULTURESFROMLOWERRESPIRATORYTRACTORBLOODCULTURES,LEUKOCYTOSIS,ELEVATIONOFCRPUTI,?1OFTHEFOLLOWINGFEVERTEMPERATURE?380°C,URINESAMPLEPOSITIVEFORNITRITE,LEUKOCYTURIA,SIGNIFICANTBACTERIURIASCHWARZETAL10BPNEUMONIA,NEWINFILTRATEONCHESTXRAYCOMPATIBLEWITHTHEDIAGNOSISOFINFECTIONPLUSATLEAST1OFTHEFOLLOWINGFEVERTEMPERATURE?380°C,LEUKOCYTOSIS?12000/ΜLORLEUKOPENIA?3000/ΜL,PURULENTTRACHEALSECRETIONSTRACHEOBRONCHITIS,PURULENTTRACHEALSECRETIONSORSPUTUMPLUSATLEAST1OFTHEFOLLOWINGFEVERTEMPERATURE?380°C,LEUKOCYTOSIS?12000/ΜLORLEUKOPENIA?3000/ΜLUTI,?25LEUKOCYTES/ΜLINTHEURINEIFNOTEXPLAINEDBYOTHERFINDINGSBACTEREMIA,BACTERIAINBLOODCULTURESSEPSIS,CLINICALEVIDENCEOFANINFECTIONWITHATLEAST2OFTHEFOLLOWINGTEMPERATURE?38°COR?35°C,TACHYCARDIA?90/MIN,TACHYPNEA?20/MIN,LEUKOCYTOSIS?12000/ΜLORLEUKOPENIA?3000/ΜLINFECTIONOFUNCLEARORIGINOROTHERINFECTIONS,CLINICALEVIDENCEOFANINFECTIONOFUNKNOWNORIGINORANYOTHERSYSTEMICINFECTIONABBREVIATIONSCRP,CREACTIVEPROTEINUTI,URINARYTRACTINFECTIONACRITERIAMODIFIEDFROMUSCENTERSFORDISEASECONTROLANDPREVENTIONCRITERIABCRITERIAFROMPAULEHRLICHSOCIETYFORCHEMOTHERAPYREPRINTEDARCHNEUROL/VOL66NO9,SEP2009WWWARCHNEUROLCOM1078?2009AMERICANMEDICALASSOCIATIONALLRIGHTSRESERVEDDOWNLOADEDFROMHTTP//ARCHNEURJAMANETWORKCOM/BYAUNIVERSITYOFAMSTERDAMUSERON08/16/2013
      下載積分: 10 賞幣
      上傳時(shí)間:2024-03-13
      頁(yè)數(shù): 6
      3人已閱讀
      ( 4 星級(jí))
    • 簡(jiǎn)介:THEREARE18MAMMALIANFIBROBLASTGROWTHFACTORSFGF1–FGF10ANDFGF16–FGF23WHICHAREGROUPEDINTO6SUBFAMILIESBASEDONDIFFERENCESINSEQUENCEHOMOLOGYANDPHYLOGENYFGF1ANDFGF2FGF3,FGF7,FGF10,FGF22FGF4,FGF5ANDFGF6FGF8,FGF17ANDFGF18FGF9,FGF16ANDFGF20ANDFGF19,FGF21ANDFGF23REF1THENUMBERED‘FGFS’THATAREUNASSIGNEDTOSUBFAMILIESTHEFGFHOMOLOGOUSFACTORSPREVIOUSLYKNOWNASFGF11–FGF14HAVEHIGHSEQUENCEIDENTITYWITHTHEFGFFAMILYBUTDONOTACTIVATEFGFRECEPTORSFGFRSANDARETHEREFORENOTGENERALLYCONSIDEREDMEMBERSOFTHEFGFFAMILY2BOX1FGF15ISTHEMOUSEORTHOLOGUEOFHUMANFGF19FGFSARECLASSICALLYCONSIDEREDTOBEPARACRINEFACTORSANDAREKNOWNFORTHEIRROLESINTISSUEPATTERNINGANDORGANOGENESISDURINGEMBRYOGENESISTHEFIRSTFIVESUBFAMILIESFALLINTOTHISCATEGORYBYCONTRAST,THEFGF19,FGF21ANDFGF23SUBFAMILYHASRECENTLYBEENSHOWNTOFUNCTIONINANENDOCRINEMANNER,DEPENDENTONTHEPRESENCEOFKLOTHOPROTEINSINTHEIRTARGETTISSUES,TOREGULATEBILEACID,CHOLESTEROL,GLUCOSE,VITAMINDANDPHOSPHATEHOMEOSTASIS3–6THEINVOLVEMENTOFFGFSIGNALLINGINHUMANDISEASEISWELLDOCUMENTEDDEREGULATEDFGFSIGNALLINGCANCONTRIBUTETOPATHOLOGICALCONDITIONSEITHERTHROUGHGAINORLOSSOFFUNCTIONMUTATIONSINTHELIGANDSTHEMSELVESFOREXAMPLE,FGF23GAINOFFUNCTIONINAUTOSOMALDOMINANTHYPOPHOSPHATAEMICRICKETS7,FGF10LOSSOFFUNCTIONINLACRIMOAURICULODENTODIGITALSYNDROMELADDSYNDROME8,FGF3LOSSOFFUNCTIONINDEAFNESS9ANDFGF8LOSSOFFUNCTIONINKALLMANNSYNDROME10ORTHROUGHGAINORLOSSOFFUNCTIONMUTATIONSINFGFRS,WHICHCONTRIBUTETOMANYSKELETALSYNDROMES41,KALLMANNSYNDROME36,LADDSYNDROME54ANDCANCERTHERAPEUTICAPPROACHESUSINGEXOGENOUSFGFS,ANTIBODIESORSMALLMOLECULESARESTILLRELATIVELYNEW,ANDMANYAVENUESOFINVESTIGATIONREMAINOPENRECOMBINANTFGF7ISALREADYINUSEFORTHETREATMENTOFCHEMORADIATIONINDUCEDORALMUCOSITISFUTUREAPPLICATIONOFTHEFGFSINRENALDISEASE,GLUCOSEANDPHOSPHATEHOMEOSTASIS,STEMCELLRESEARCH,TISSUEREPAIRANDBIOENGINEERING,ANDANGIOGENESISISEXPECTEDCONTINUEDEFFORTSTOUNDERSTANDTHESTRUCTURALBIOLOGYOFFGF–FGFRINTERACTIONSWILLPLAYAKEYPARTINDRIVINGTHEDISCOVERYOFNEWTHERAPIESINTHISARTICLE,WEBRIEFLYREVIEWCURRENTKNOWLEDGEREGARDINGFGF–FGFRSIGNALLINGANDTHENFOCUSONTHEBIOLOGY,PATHOLOGYANDRECENTDEVELOPMENTSREGARDINGTHEPHARMACOLOGICALAPPLICATIONSOFEACHLIGANDTHEFGF–FGFRSIGNALLINGSYSTEMFGFSALLFGFS,EXCEPTTHOSEINSUBFAMILIESFGF1ANDFGF2,ANDFGF9,FGF16ANDFGF20,HAVESIGNALPEPTIDESTHEFGF9,FGF16ANDFGF20SUBFAMILYISNONETHELESSSECRETEDTHROUGHTHETRADITIONALENDOPLASMICRETICULUMER–GOLGISECRETORYPATHWAY11,WHEREASTHEFGF1ANDFGF2SUBFAMILYISSECRETEDINDEPENDENTLY12FGFSHAVEAHOMOLOGOUSCOREREGIONTHATCONSISTSOF120–130AMINOACIDSORDEREDINTO12ANTIPARALLELΒSTRANDSΒ1–Β12FLANKEDBYDIVERGENTAMINOANDCARBOXYLTERMINIFIG1AINGENERAL,PRIMARYSEQUENCEVARIATIONOFTHENANDCTERMINALTAILSOFFGFSACCOUNTSFORTHEDIFFERENTBIOLOGYOFTHELIGANDS13FIG1BTHEHEPARANSULPHATEGLYCOSAMINOGLYCANHSGAGBINDINGSITEHBSWITHINTHEFGFCOREISCOMPOSEDOFTHEΒ1–Β2LOOPANDPARTSOFTHEREGIONSPANNINGΒ10ANDΒ12FORPARACRINEFGFS,DEPARTMENTOFPHARMACOLOGY,NEWYORKUNIVERSITYSCHOOLOFMEDICINE,NEWYORK,NEWYORK10016,USAEMAILSANDREWBEENKENMEDNYUEDUMOOSAMOHAMMADINYUMCORGDOI101038/NRD2792AUTOSOMALDOMINANTHYPOPHOSPHATAEMICRICKETSAHEREDITARYDISORDEROFPHOSPHATEWASTINGCHARACTERIZEDBYRICKETS,LOWEREXTREMITYDEFORMITIESANDOSTEOMALACIALACRIMOAURICULODENTODIGITALSYNDROMELADDASYNDROMECHARACTERIZEDBYABNORMALITIESOFTHEDIGITSANDTEETH,LOWSETEARSANDAPLASIAOFTHELACRIMALANDSALIVARYGLANDSMUTATIONSINFGFR2ANDFGF10AREKNOWNTOCAUSELADDKALLMANNSYNDROMETHISSYNDROMERESULTSFROMADEFICIENCYOFGONADOTROPINRELEASINGHORMONE,WHICHLEADSTOHYPOGONADISMMUTATIONSINFGFR1CANDFGF8AREKNOWNTOCAUSEKALLMANNSYNDROMETHEFGFFAMILYBIOLOGY,PATHOPHYSIOLOGYANDTHERAPYANDREWBEENKENANDMOOSAMOHAMMADIABSTRACT|THEFAMILYOFFIBROBLASTGROWTHFACTORSFGFSREGULATESAPLETHORAOFDEVELOPMENTALPROCESSES,INCLUDINGBRAINPATTERNING,BRANCHINGMORPHOGENESISANDLIMBDEVELOPMENTSEVERALMITOGENIC,CYTOPROTECTIVEANDANGIOGENICTHERAPEUTICAPPLICATIONSOFFGFSAREALREADYBEINGEXPLORED,ANDTHERECENTDISCOVERYOFTHECRUCIALROLESOFTHEENDOCRINEACTINGFGF19SUBFAMILYINBILEACID,GLUCOSEANDPHOSPHATEHOMEOSTASISHASSPARKEDRENEWEDINTERESTINTHEPHARMACOLOGICALPOTENTIALOFTHISFAMILYTHISREVIEWDISCUSSESTRADITIONALAPPLICATIONSOFRECOMBINANTFGFSANDSMALLMOLECULEFGFRECEPTORKINASEINHIBITORSINTHETREATMENTOFCANCERANDCARDIOVASCULARDISEASEANDTHEIREMERGINGPOTENTIALINTHETREATMENTOFMETABOLICSYNDROMEANDHYPOPHOSPHATAEMICDISEASESREVIEWSNATUREREVIEWS|DRUGDISCOVERYVOLUME8|MARCH2009|235?2009MACMILLANPUBLISHERSLIMITEDALLRIGHTSRESERVEDCANATUREREVIEWS|DRUGDISCOVERYFGF1FGF2FGF3FGF7FGF10FGF22FGF4FGF5FGF6FGF8FGF17FGF18FGF9FGF16FGF20FGF19FGF21FGF23EKFNLPPGNYKKPKLLYCGSGAFPPGHFKDPKRLYCGGVYEHLGGAPRRRKLYCRSYDYMEGGDIRVRRLFCVRSYNHLQGDVRWRKLFSPRSYPHLEGDVRWRRLFSSGAGDYLLGIKRLRRLYCQSSFQWSPSGRRTGSLYCNWESGYLVGIKRQRRLYCLVTDQLSRRLIRTYQLYSAMTDQLSRRQIREYQLYSRARDDVSRKQLRLYQLYSVTDLDHLKGILRRRQLYCPTDFAHLKGILRRRQLYCAAQLAHLHGILRRRQLYCPHVHYGWGDPIRLRHLYTSSPLLQFGGQVRQRYLYTNASPLLGSSWGGLIHLYT143734556831726774424343494852333527313451728548898491596060666569505244BΒ1CTERMINUSNTERMINUSΒ9Β8Β6Β4Β7Β5Β3Β2Β10Β11Β1Β12FGFR1ATLEASTTHREEGENETICDISORDERSCANBEATTRIBUTEDTOMUTATIONSINFGFR1KALLMAN’SSYNDROME36,OSTEOGLOPHONICDYPLASIAANDPFEIFFER’SSYNDROME37PATHOLOGICALFGFR1SIGNALLINGALSOOCCURSINVARIOUSMALIGNANCIESGLIOBLASTOMABRAINTUMOURSEXHIBITFGFR1KINASEDOMAINGAINOFFUNCTIONMUTATIONS38,ANDFGFR1ISABNORMALLYACTIVATEDCRANIOSYNOSTOSISTHISCONDITIONRESULTSFROMTHEPREMATURECLOSUREOFSUTURESOFADEVELOPINGSKULLBEFORETHECOMPLETIONOFBRAINGROWTHTHEBRAINCONTINUESTOGROWINAREASOFTHESKULLWHERESUTURESHAVENOTCLOSED,LEADINGTOAMALFORMEDCRANIUMAPERT’SSYNDROMEONEOFTHEMOSTCOMMONCRANIOSYNOSTOSISSYNDROMESTHATEXHIBITSSEVERESYNDACTYLYDIGITFUSIONOFTHEHANDSANDFEETAPERT’SSYNDROMEISOFTENASSOCIATEDWITHVISCERALABNORMALITIESOFTHECARDIOVASCULAR,RESPIRATORYANDUROGENITALSYSTEMSOSTEOGLOPHONICDYSPLASIAABONEDISORDERPRESENTINGWITHDWARFISM,VERTEBRALFRAGILITY,CRANIOSYNOSTOSISANDFAILURETOTHRIVETHETERMOSTEOGLOPHONICREFERSTOTHE‘HOLLOWEDOUT’APPEARANCEOFTHEMETAPHYSESINXRAYS,WHICHARETHEGROWTHZONESOFLONGBONESPFEIFFER’SSYNDROMEACRANIOSYNOSTOSISDISORDERTHATCANALSOPRESENTWITHPOLYDACTYLYGLIOBLASTOMAANAGGRESSIVETUMOURDERIVEDFROMGLIALCELLSTHATEXHIBITSHIGHLEVELSOFNEOVASCULARIZATIONMODULATORSOFFGFSIGNALLINGFGFBINDINGPROTEINFGFBPISACARRIERPROTEIN27THATACTIVATESFGFSBYRELEASINGTHEMFROMTHEEXTRACELLULARMATRIX,WHERETHEYAREBOUNDBYHSGAGS28FGFBPHASBEENSHOWNTOINCREASEFGF2DEPENDENTPROLIFERATIONOFFIBROBLASTCELLS29ANDMAYHAVEANIMPORTANTROLEINTHEDEVELOPMENTOFSOMECANCERS30OTHERACTIVATORSOFFGFSIGNALLINGINCLUDEFIBRONECTINLEUCINERICHTRANSMEMBRANEPROTEIN3FLRT3,WHICHFACILITATESFGF8ACTIVITYTHROUGHTHEMAPKPATHWAY31THESPROUTYFAMILYOFPROTEINSPLAYANIMPORTANTPARTININHIBITINGRECEPTORTYROSINEKINASERTKSIGNALLINGANDWEREFIRSTDISCOVEREDASINHIBITORSOFFGFSINDROSOPHILAMELANOGASTER32FGFSIGNALLINGACTIVATESSPROUTYPROTEINS,WHICHCANTHENINTURNINHIBITFGFSTIMULATIONOFTHEMAPKPATHWAYBYINTERACTINGWITHGRB2GROWTHFACTORRECEPTORBOUNDPROTEIN2,SOS1ORRAF1REF33MKP3MAPKPHOSPHATASE3ISANOTHERGENERALINHIBITOROFRTKSIGNALLINGTHATALSOIMPINGESONFGFACTIVITYBYDEPHOSPHORYLATINGEXTRACELLULARSIGNALREGULATEDKINASEERK34SEFISASPECIFICINHIBITOROFFGFSTHATCANFUNCTIONATMULTIPLEPOINTSALONGTHESIGNALLINGPATHWAYTOATTENUATESIGNALLING34FGFRPATHOPHYSIOLOGYANDTHERAPYGERMLINEGAINOFFUNCTIONMUTATIONSINFGFRSARERESPONSIBLEFORVARIOUSDISEASES,SUCHASCRANIOSYNOSTOSIS,DWARFINGSYNDROMESANDCANCERMOSTOFTHEFGFRMUTATIONSARELIGANDINDEPENDENT,BUTAFEWSUCHASSER252TRPANDPRO253ARGINTHEECTODOMAINOFFGFR2MANIFESTONLYDURINGLIGANDBINDINGTHESEMUTATIONSCAUSEAPERT’SSYNDROMEBYENHANCINGLIGANDBINDINGAFFINITYANDPROMOTINGTHEBINDINGOFINAPPROPRIATELIGANDS35,278–280REMARKABLY,MANYOFTHEGERMLINEMUTATIONSTHATCAUSESKELETALSYNDROMESALSOCONTRIBUTE,THROUGHSOMATICMUTATIONS,TOTHEDEVELOPMENTOFCANCERFURTHERMORE,MUTATIONSINFGFR1–FGFR3OFTENOCCURINHOMOLOGOUSRESIDUESANDACCOUNTFORMULTIPLEPATHOLOGIESFIGURE1|STRUCTURALFEATURESOFFIBROBLASTGROWTHFACTORSFGFSA|FGF1,SHOWINGITS12ANTIPARALLELΒSHEETSANDAMINOANDCARBOXYLTERMINIB|THE18FGFS,GROUPEDACCORDINGTOSUBFAMILYTHESEQUENCEALIGNMENTINTHEREGIONOFTHEDIVERGENTNTERMINUSPROXIMALTOTHEΒTREFOILCOREISGIVENTHEΒ1STRANDOFFGF1ISPROVIDEDTOINDICATETHELIMITOFTHENTERMINUSC|FGF19SUPERIMPOSEDONTOFGF2FROMTHEFGF2–FGFRECEPTOR1–HEPARINTERNARYSTRUCTUREPROTEINDATABANKFGF2ANDFGF19ARERENDEREDASRIBBONSANDHEPARINISSHOWNASSTICKSOXYGENRED,NITROGENBLUE,CARBONBEIGE,ANDSULPHURGREENATOMSARESHOWNTHECOREREGIONSOFBOTHLIGANDSARECOLOUREDGREY,ANDTHEHEPARINBINDINGREGIONSOFFGF2ANDFGF19ARECOLOUREDCYANANDORANGE,RESPECTIVELYHEPARINFROM1FQ9CLASHESWITHTHERIDGESINTHEHEPARINBINDINGREGIONOFFGF19TOELIMINATETHESECLASHES,HEPARINMUSTTRANSLOCATEAWAYFROMFGF19BUT,INDOINGSO,CRUCIALCONTACTSBETWEENHEPARINANDTHEFGF19BACKBONECANNOTBEMADETHEWEAKENEDHEPARINBINDINGOBSERVEDINTHEFGF19SUBFAMILYMEMBERSISRESPONSIBLEFORTHEIRENDOCRINEBEHAVIOURREVIEWSNATUREREVIEWS|DRUGDISCOVERYVOLUME8|MARCH2009|237?2009MACMILLANPUBLISHERSLIMITEDALLRIGHTSRESERVED
      下載積分: 10 賞幣
      上傳時(shí)間:2024-03-13
      頁(yè)數(shù): 19
      9人已閱讀
      ( 4 星級(jí))
    • 簡(jiǎn)介:IEEEVEHICLEPOWERANDPROPULSIONCONFERENCEVPPC,SEPTEMBER35,2008,HARBIN,CHINA9781424418497/08/2500○C2008IEEEDESIGNANDDEVELOPMENTOFFEWTOOTHDEFERENCEPLANETARYGEARPOWERTRAINCOUPLINGSYSTEMWITHBIASEDBENTSHAFTINELECTRICANDHEVFORALLTERRAINVEHICLESWANGYONGBINZHANGZENGNIANCHENWENXINYANGYAPINGLIANGFENGTUXIAOFENGSHIYIPINGZHANGXINLICHANGGANGZHEJIANGWANLIUNIVERSITY/SCHOOLOFELECTRONICANDINFORMATIONENGINEERING,NINGBOCITY,PRCHINAEMAILWYBZWUEDUCNABSTRACTTHEARTICLEHASANALYZEDTHEDOMESTICANDINTERNATIONALPRESENTRESEARCHSTATUSANDDEVELOPMENTTRENDOFTHEELECTRICANDHYBRIDELECTRICVEHICLESHEVCONSIDERINGACTUALSCIENTIFICRESEARCH,ACCORDINGTOTHECHARACTERISTICANDENVIRONMENTREQUIREMENTOFALLTERRAINVEHICLE(ATV),THEPRINCIPLEOFELECTEDANDDESIGNEDCOMPONENTPARTSFORPOWERTRAINCOUPLINGSYSTEMOFATV,ANDTHEDEMANDSOFPERFORMANCEPARAMETEROFPOWER,TORQUEANDSPEEDOFMOVINGATV,THISARTICLESTUDIESONTHEPERFORMANCEPARAMETERANDCONTROLSTRATEGYOFPOWERTRAINCOUPLINGSYSTEMOFENGINE,ELECTRICMOTORANDTHESTORAGEBATTERYTHEOPTIMIZATIONMATCHING,THEMODELINGSIMULATIONANDTHEEXPERIMENTHAVEBEENCARRIEDOUTTHEARTICLEPROPOSESANEWMULTIPURPOSEDESIGNANDDEVELOPMENTPLANONTHEPOWERTRAINCOUPLINGSYSTEMINELECTRICANDHEVFORATVSITINTRODUCESANEWTRANSMISSIONSYSTEMBASEDONFEWTOOTHDEFERENCEPLANETARYGEARPOWERTRAINCOUPLINGSYSTEMWITHBIASEDBENTSHAFT(FPS),WHICHHAVEBEENAPPLIEDINPOWERTRAINCOUPLINGSYSTEMOFTHEMULTIPURPOSELIGHTELECTRICANDHEVFORATVTHERESEARCHRESULTSSHOWTHATTHEPROPOSEDFPSMEETSTHEPERFORMANCEREQUIREMENTFORENTIREVEHICLE(ATV),ESPECIALLYINREGARDINFINITELYVARIABLESPEEDTHEMETHODANDTHEOBTAINEDRESULTPROVIDETHEBASISDESIGNTHEORYFORTHELOWSPEEDVEHICLESTHATIS,AGRICULTURALVEHICLESANDMULTIPURPOSELIGHTELECTRICANDHEVSTHETECHNOLOGYHASBEENAPPLIEDTOATVSINNINGBOSAITINGELECTRICBICYCLESCIENCEPOWERTRAINCOUPLINGSYSTEMFEWTOOTHDEFERENCEPLANETARYGEARTRANSMISSIONOPTIMIZEMATCHINGIINTRODUCTIONUPTOTHEPRESENT,THELOWSPEEDVEHICLESANDATVYETNOTUSEDTHETECHNOLOGYOFTHEELECTRICANDHEVACCORDINGTOLOWSPEEDVEHICLESANDATVOFHEVINROAD,ENVIRONMENT,SPEEDANDLOADSITUATIONS,THROUGHTHEENGINE,THERECHARGEABLEBATTERYANDTHEELECTRICMOTOR/GENERATOROPTIMALFIT,ITSTUDIESONEKINDDESIGNANDDEVELOPMENTPLANOFTHENEWPOWERTRAINCOUPLINGSYSTEMINELECTRICANDHEVFORATVITFOCALINTRODUCESTHENEWTRANSMISSIONSETBASEDONTHEFPS,WHICHHAVEAPPLIEDINPOWERTRAINCOUPLINGSYSTEMOFTHEMULTIPURPOSELIGHTELECTRICANDHEVFORATV,ITEMPHASISINTRODUCESITSAPPLICATIONBECAUSETHEFPSHAVEMERITSOFTHESTRUCTURECOMPACT,THEVELOCITYRATIOBIG,THEEFFICIENCYHIGH,THEREVOLUTIONSTEADY,BEARINGCAPACITYSTRONG,THEPROCESSINGSIMPLE,THECOSTLOWSTATUSITMAYAPPLYINTHEATV,THENATIONALDEFENSE,THEMETALLURGY,THEMINELIFTSHEAVYOBJECTSPROFESSIONSANDSOONTRANSPORTATION,MEASURINGAPPLIANCEMANUFACTURE,ETC1THEFPSMAYENHANCETHEENGINEWORKINGEFFICIENCY,SAVETHEENERGY,DISCHARGECLEANLY,ANDREDUCETHEENVIRONMENTALPOLLUTIONANDSOONTHISKINDOFVEHICLEBESIDESTHEENGINECANCHARGETOTHEBATTERY,THEPOWERCANBEREGENERATEDTOBATTERYWHENVEHICLEISINDECELERATION,THEBRAKECANTRANSFORMMECHANICALENERGYTOELECTRICALENERGYAVOIDINGTHEENERGYWASTEWITHTHEHEV,THEFUELEFFICIENCYOFVEHICLEMAYENHANCEONETIMECOMPAREDTOTHEORDINARYVEHICLE,SIMULTANEOUSLYCHANGESCO2WITHDRAWALTOONEHALF,WHICHLEADTHEEARTHTOWARMITISINNOVATIVETHATTHEATVUSESTHEHEVTECHNOLOGY,ANDTHEBREAKTHROUGHPOINTOFINFINITELYVARIABLESPEEDISAPPROPRIATEHAVINGTHEBROADMARKETAPPLICATIONPROSPECT,THISTECHNOLOGYALSOMAYBEUSEDINTHEATV,ANDITWILLHAVEHUGEDEVELOPMENTPOTENTIALANDFAVORABLEMARKETPROSPECTTHEDESIGNINGANDDEVELOPINGLIGHTELECTRICANDHYBRIDELECTRICVEHICLESENUMBEROFTEETHZAANDZBMODULEMNGRADUATEDCIRCLEHELIXANGLEΒFACEWIDTHBAANDBBSPEEDRATIOI45OFFPSWITHLOWSPEEDLEVELMODULEMNUMBERDIFFERENCEOFTEETHZDNUMBEROFTEETHZ3ANDZ4STANDOFFCOEFFICIENTY3ANDY4ADDENDUMCOEFFICIENTHAWORKINGPRESSUREANGLEΑ′FACEWIDTHB3ANDB4AMONGTHEVARIABLEUP,THEINDEPENDENTDESIGNVARIABLEHAVEI12、ZA、MN、Β、B1、M、ZD、Z3、Y3、Y4、B3THEREFORE,THEDESIGNVARIABLE18,19,20ISXIAB,ZA,MN,Β,B1,M,ZD,Z3,Y3,Y4,HA,B3TX1,X2,X3,X4,X5,X6,X7,X8,X9,X10,X11,X12TCOBJECTIVEFUNCTIONUSESTHEFPSINTHEATVMAINLYAREINORDERTOOBTAINTHESMALLSTRUCTURESIZETHEREFORE,THEMOSTRESEARCHSINGLETARGETISOPTIMIZINGBYTHESTRUCTUREVOLUMEFORSMALLESTINORDERTOCALCULATECONVENIENTLY,ITUSUALLYTAKESVARIOUSGEARSREFERENCEVOLUMEASCOMPUTATIONBASISTHUS,FIRST,ADDENDUMCOEFFICIENTHA,STANDOFFCOEFFICIENTY3ANDY4WORKINGPRESSUREANGLEΑ′ANDSOONPARAMETERSCANNOTREFLECTINTHEOBJECTIVEFUNCTION,BUTTHESEPARAMETERSHAVETHEREFLECTIONINCONSTRAINTCONDITION,SUCHASTOOTHPROFILEOVERLAPINTERFERENCE,PINIONTRANSITIONCURVEINTERFERENCEANDCONTACTRATIOIFDEPENDSONTHEEXPERIENCETODETERMINETHEM,SOMETIMESCAUSESNOTTOBEABLETOSATISFYTHECONSTRAINTCONDITIONSECOND,INORDERTOSATISFYTHEFPSTOOTHPROFILENOTTOOVERLAPTHEINTERFERENCECONDITION,THETRANSMISSIONGENERALLYUSESCLOCKWISEDRIVEANDSIMULTANEOUSLYREDUCESADDENDUMCOEFFICIENTHA,BUTUSESTHECLOCKWISEDRIVECANCAUSETHETRANSMISSIONWORKINGPRESSUREANGLEΑ′TOINCREASE,ANDCAUSESTHECRANKSHAFTBEARINGRADIALFORCETOINCREASE,THUSAFFECTSTHEBEARINGLIFEANDTHETRANSMISSIONEFFICIENCY4,5INTHEFPSDESIGN,THEWORKINGPRESSUREANGLEΑ′ISANIMPORTANTPARAMETERMUSTTAKEAMOREAPPROPRIATEVALUEINORDERTOCAUSETHETRANSMISSIONDEVICEWEIGHTTOBELIGHT,THEVOLUMEISSMALL,HASHIGHTRANSMISSIONEFFICIENCY,ANDHASHIGHSERVICELIFE,THISARTICLETAKETHEVARIOUSGEARSVOLUMESUMISSMALLESTANDTHEWORKINGPRESSUREANGLEΑ′ISSMALLESTASTHEDOUBLEOPTIMIZEDGOAL4,5,NAMELYINVΑ′INVΑ2Y4Y3/ZDTAN?。?)INTHEFORMULAINVΑTANΑΑ,ΑISTHEPRESSUREANGLEOFREFERENCECIRCLEVV1V2V3V4Π/4DA12B12DA22B12DF32B3DA42B3(6)INTHEFORMULA,DA1、DA2、DA5RESPECTIVELYARETHETIPDIAMETEROFGEAR1、2AND5DF3ISTHEROOTDIAMETEROFGEAR3THEOBJECTIVEFUNCTIONISFXΩ1INVΑ′/INVΑ′Ω2V/V(7)INTHEFORMULA,Ω1、Ω2ARETHEWEIGHTINGFACTOR,TAKESΩ11,Ω22,EXPRESSIONTHEVOLUMEFORMAINOPTIMIZEDGOAL,ANDTHEWORKINGPRESSUREANGLEFORSECONDARYOPTIMIZEDGOALΑ′、VRESPECTIVELYISTHEWORKINGPRESSUREANGLEANDTHEVOLUMEEMPIRICALVALUEDCONSTRAINTCONDITION1THECONSTRAINTCONDITIONOFMOVEMENTPERFORMANCEATHELIMITINGCONDITIONOFTOOTHPROFILEOVERLAPINTERFERENCEOFINTERNALANDEXTERNALGEAR,G1XZ5INVΑA4Δ2Z3INVΑA3Δ1Z5Z3INVΑ′≤0322324112COSΑΑΔAAARRR??422324122COSΑΑΔAAARRR??INTHEFORMULA,A′ISACENTERDISTANCEOFTHEGEAR3AND5BTHELIMITINGCONDITIONOFINNERENGAGEMENTCONTACTRATIOG2XZ3TANΑA3TANΑ′Z5TANΑA4–TANΑ′/2Π≥105CTHELIMITINGCONDITIONOFTRANSITIONCURVEINTERFERENCEOFINNERANDANNULARGEARG3XZ3TANΑA1Z5Z3TANΑ′Z5Z0TANΑ04′Z0TANΑA0≤0INTHEFORMULA,Z0ISTHETOOTHNUMBEROFINTERNALGEARTOOTHSLOTTINGTOOL,ΑA0ISTHEWORKINGPRESSUREANGLEOFTIPCIRCLEOFINTERNALGEARTOOTHSLOTTINGTOOL,Α04′ISWORKINGPRESSUREANGLEBETWEENINTERNALGEARTOOTHSLOTTINGTOOLANDINNERGEARDTHEINTERFERENCELIMITINGCONDITIONOFINNERGEARTOPCUTG4X1Z3/Z5TANΑA4/TANΑ′≤0ETHEINTERFERENCELIMITINGCONDITIONOFINNERGEARUNDERCUTG5XHAZ5SIN2Α/2Y4≤0FTHELIMITINGCONDITIONOFAPEXCLEARANCEOFINNERGEARINGGEARG6XRA3RF4CM≤02CONSTRAINTCONDITIONOFINTENSITYATHELIMITINGCONDITIONOFCONTACTFATIGUESTRENGTHOFFLANKOFTOOTHG7,8XΣH1、3ΣH1、31≥0INTHEFORMULA,ΣH1、3ISALLOWABLECONTACTSTRESSOFGEAR1AND3,ΣH1、3ISCONTACTSTRESSOFGEAR1AND3BTHELIMITINGCONDITIONOFBENDEDFATIGUESTRENGTHOFDEDENDUM
      下載積分: 10 賞幣
      上傳時(shí)間:2024-03-13
      頁(yè)數(shù): 5
      3人已閱讀
      ( 4 星級(jí))
    • 簡(jiǎn)介:JSERBCHEMSOC717733–7442006UDC54728854291361528JSCS–3467ORIGINALSCIENTIFICPAPERSYNTHESISANDANTIBACTERIALACTIVITYOFSOMESCHIFFBASECOMPLEXESRNAIR1,ASHAH2,SBALUJA2ANDSCHANDA11DEPARTMENTOFBIOSCIENCESAND2DEPARTMENTOFCHEMISTRY,SAURASHTRAUNIVERSITY,RAJKOT360005,GUJARAT,INDIAEMAILSUMITRACHANDAYAHOOCOMRECEIVED6JULY,REVISED9NOVEMBER2005ABSTRACTTWOSCHIFFBASESWERESYNTHESIZEDFROMRACEACETOPHENONE1ADS14ETHYL6{E13NITROPHENYLIMINOETHYL}BENZENE1,3DIOLAND2ADS34ETHYL6{E12NITROPHENYLIMINOETHYL}BENZENE1,3DIOLTHENTHEIRMETALCOMPLEXESWEREFORMEDTHEMETALSSELECTEDFORTHEPREPARATIONOFCOMPLEXESWERECOPPER,NICKEL,IRONANDZINCHENCE,INTOTAL8METALCOMPLEXESWERESYNTHESIZEDANDSCREENEDFORANTIBACTERIALACTIVITYAGAINSTSOMECLINICALLYIMPORTANTBACTERIA,SUCHASPSEUDOMONASAERUGINOSA,PROTEUSVULGARIS,PROTEUSMIRABILIS,KLEBSIELLAPNEUMONIAEANDSTAPHYLOCOCCUSAUREUSTHEINVITROANTIBACTERIALACTIVITYWASDETERMINEDBYTHEAGARDITCHTECHNIQUEUSINGDMFPOLARAND1,4DIOXANENONPOLARASSOLVENTSTHESCHIFFBASESSHOWEDGREATERACTIVITYTHANTHEIRMETALCOMPLEXESTHEMETALCOMPLEXESSHOWEDDIFFERENTIALEFFECTSONTHEBACTERIALSTRAINSINVESTIGATEDANDTHESOLVENTUSED,SUGGESTINGTHATTHEANTIBACTERIALACTIVITYISDEPENDENTONTHEMOLECULARSTRUCTUREOFTHECOMPOUND,THESOLVENTUSEDANDTHEBACTERIALSTRAINUNDERCONSIDERATIONTHESCHIFFBASEADS3INTHEPOLARSOLVENTDMFSHOWEDBETTERANTIBACTERIALACTIVITYTOWARDSTHEINVESTIGATEDBACTERIALSTRAINSAMONGSTTHEFOURMETALS,ZNSHOWEDTHEBESTANTIBACTERIALACTIVITYFOLLOWEDBYFEIN1,4DIOXANEWHILENIFOLLOWEDBYZNANDFESHOWEDTHEBESTANTIBACTERIALACTIVITYINDMFPVULGARISWASTHEMOSTRESISTANTBACTERIAKEYWORDSSCHIFFBASECOMPLEXES,ANTIBACTERIALACTIVITY,DMF,1,4DIOXANEINTRODUCTIONTOOVERCOMETHEALARMINGPROBLEMOFMICROBIALRESISTANCETOANTIBIOTICS,THEDISCOVERYOFNOVELACTIVECOMPOUNDSAGAINSTNEWTARGETSISAMATTEROFURGENCYMANYOFTHECRUDEDRUGS,WHICHARESOURCESOFMEDICINALPREPARATIONS,STILLORIGINATEFROMWILDGROWINGMATERIALHOWEVER,PLANTBASEDDRUGSHAVESHORTENEDTHELIFESPANOFTHESOURCEOFMATERIALTHEREISACONTINUOUSSEARCHFORMOREPOTENTANDCHEAPERRAWMATERIALSTOFEEDTHEINDUSTRYCOMPOUNDS,WHICHONDISSOLUTIONDONOTGIVEIONSOFWHICHTHEYAREMADEBUTINSTEADGIVECOMPLEXIONSARECALLEDCOORDINATIONCOMPOUNDSCOORDINATIONCOMPO733DOI102298/JSC0607733NAUTHORFORCORRESPONDENCENOLIC–OHGROUPTHEMETALSSELECTEDFORTHEPREPARATIONOFTHECOMPLEXESWERECOPPER,NICKEL,IRONANDZINCTHESYNTHESISOFMETALCOMPLEXESWASSTUDIEDATDIFFERENTPHVALUESFORDIFFERENTMETALS,THEMAXIMUMYIELDWASOBSERVEDATDIFFERENTPHVALUESTHEPHOFMAXIMUMYIELDWASSELECTEDFORTHESYNTHESISOFEACHCOMPLEXFOREACHMETALCOMPLEX,DIFFERENTMETALSALTSOLUTIONSWEREPREPAREDTHESOLUTIONSUSEDFORTHESYNTHESISOFTHECOPPER,NICKEL,IRONANDZINCCOMPLEXESWERECUPRICCHLORIDE,NICKELCHLORIDE,FERROUSAMMONIUMSULPHATEANDZINCCHLORIDE,RESPECTIVELYSYNTHESISOFCOPPERCOMPLEXES01MSOLUTIONOFLIGANDANDCUPRICCHLORIDEWEREPREPAREDIN1,4DIOXANEANDDISTILLEDWATER,RESPECTIVELYACETICACIDANDSODIUMACETATEWEREADDEDTOTHECUPRICCHLORIDESOLUTIONTOMAINTAINTHEPH65–70THELIGANDSOLUTIONWASADDEDDROPWISETOTHEMETALIONSOLUTIONADARKBROWNPRECIPITATEWASOBTAINEDTHEPHOFSOLUTIONWASMAINTAINEDBYTHEBUFFERSOLUTIONANDTHESOLUTIONWASREFLUXEDFOR4–5HINAWATERBATHTHEPRECIPITATEWASFILTEREDANDWASHED,FIRSTWITH1,4DIOXANEANDTHENWITHHOTWATERTOREMOVEEXCESSLIGANDANDMETALIONS,RESPECTIVELYTHEPRECIPITATEWASTHENDRIEDSYNTHESISOFNICKELCOMPLEXES01MSOLUTIONOFLIGANDANDNICKELCHLORIDEAREPREPAREDIN1,4DIOXANEANDDISTILLEDWATER,RESPECTIVELYTHELIGANDSOLUTIONWASADDEDDROPWISETOTHEMETALIONSOLUTIONTHEPHWASMAINTAINEDBETWEEN10–105BYADDINGAMMONIUMHYDROXIDEAYELLOWISHORANGEPRECIPITATEWASOBTAINEDONREFLUXINGTHESOLUTIONONAWATERBATHFOR4–5HTHEPRECIPITATEWASFILTEREDANDWASHEDWITHHOTWATERAND1,4DIOXANETOREMOVEEXCESSLIGANDANDMETALIONS,RESPECTIVELYTHEPRECIPITATEWASTHENDRIEDSYNTHESISOFIRONCOMPLEXES01MLIGANDSOLUTIONIN1,4DIOXANEWASADDEDDROPWISETOA01MFERROUSAMMONIUMSULPHATESOLUTIONINTHEPRESENCEOFABUFFERSOLUTIONAMMONIUMHYDROXIDEACETICACIDTOMAINTAINTHEPHBETWEEN7–75THESOLUTIONWASREFLUXEDFOR5–6HTHEFORMEDYELLOWISHBROWNPRECIPITATEWASFILTERED,WASHEDWITHHOTWATERAND1,4DIOXANETOREMOVEEXCESSLIGANDANDMETALIONS,RESPECTIVELYTHEPRECIPITATEWASTHENDRIEDSYNTHESISOFZINCCOMPLEXES01MLIGANDSOLUTIONIN1,4DIOXANEWASADDEDDROPWISETOA01MZINCCHLORIDESOLUTIONINPRESENCEOFBUFFERSOLUTIONANDAMMONIUMHYDROXIDETOMAINTAINTHEPHBETWEEN10–11THESOLUTIONWASREFLUXEDFOR4–5HINAWATERBATHTHEFORMEDBROWNPRECIPITATEWASFILTERED,WASHEDWITHHOTWATERAND1,4DIOXANETOREMOVEEXCESSLIGANDANDMETALIONS,RESPECTIVELYTHEPRECIPITATEWASTHENDRIEDANTIBACTERIALACTIVITYANTIBACTERIALACTIVITYWASDETERMINEDBYTHEAGARDITCHMETHOD15THEINVESTIGATEDMICROORGANISMSWEREPSEUDOMONASAERUGINOSA,PROTEUSVULGARIS,PROTEUSMIRABILIS,KLEBSIELLAPNEUMONIAEANDSTAPHYLOCOCCUSAUREUSTHECOMPOUNDSWEREDISSOLVEDINONEOFTHETWOSOLVENTS1,4DIOXANEORDMFTOOBTAINAFINALCONCENTRATION1MG/01MLALOOPFULLOFTHEGIVENTESTSTRAINWASINOCULATEDIN25MLOFNBROTHNUTRIENTBROTHANDINCUBATEDFOR24HINANINCUBATORAT37oCINORDERTOACTIVATETHEBACTERIALSTRAIN28–30MLOFTHENUTRIENTAGARMEDIAWASADDEDINTOA100MMDIAMETERPETRIPLATEINOCULATIONWASDONEBYTHEPOURPLATETECHNIQUE02MLOFTHEACTIVATEDSTRAINWASINOCULATEDINTOTHEMEDIAWHENITREACHEDATEMPERATUREOF40–45oCTHECOMPLETEPROCEDUREOFTHEPLATEPREPARATIONWASDONEINALAMINARAIRFLOWTOMAINTAINSTRICTSTERILEANDASEPTICCONDITIONTHEMEDIUMWASALLOWEDTOSOLIDIFYAFTERSOLIDIFICATIONOFTHEMEDIA,AWELLWASMADEINTHEPLATESWITHTHEHELPOFACUPBORER085CM,WHICHWASTHENFILLEDWITHONEOFTHETESTSAMPLESOLUTIONSCONTROLSWERERUNFOREACHBACTERIALSTRAINANDEACHSOLVENT,WHEREPURESOLVENTWASINOCULATEDINTOTHEWELLTHEPLATESWEREINCUBATEDFOR24HAT37oCTHEINHIBITIONZONEFORMEDBYTHESECOMPOUNDSSCHIFFBASECOMPLEXES735
      下載積分: 10 賞幣
      上傳時(shí)間:2024-03-14
      頁(yè)數(shù): 12
      11人已閱讀
      ( 4 星級(jí))
    • 簡(jiǎn)介:JOURNALOFCONTROLTHEORYANDAPPLICATIONS20075183–88DOI101007/S1176800552586NEUROFUZZYGENERALIZEDPREDICTIVECONTROLOFBOILERSTEAMTEMPERATUREXIANGJIELIU1,JIZHENLIU1,PINGGUAN21DEPARTMENTOFAUTOMATION,NORTHCHINAELECTRICPOWERUNIVERSITY,BEIJING102206,CHINA2DEPARTMENTOFAUTOMATION,BEIJINGINSTITUTEOFMACHINERY,BEIJING100085,CHINAABSTRACTPOWERPLANTSARENONLINEARANDUNCERTAINCOMPLEXSYSTEMSRELIABLECONTROLOFSUPERHEATEDSTEAMTEMPERATUREISNECESSARYTOENSUREHIGHEFFICIENCYANDHIGHLOADFOLLOWINGCAPABILITYINTHEOPERATIONOFMODERNPOWERPLANTANONLINEARGENERALIZEDPREDICTIVECONTROLLERBASEDONNEUROFUZZYNETWORKNFGPCISPROPOSEDINTHISPAPERTHEPROPOSEDNONLINEARCONTROLLERISAPPLIEDTOCONTROLTHESUPERHEATEDSTEAMTEMPERATUREOFA200MWPOWERPLANTFROMTHEEXPERIMENTSONTHEPLANTANDTHESIMULATIONOFTHEPLANT,MUCHBETTERPERFORMANCETHANTHETRADITIONALCONTROLLERISOBTAINEDKEYWORDSNEUROFUZZYNETWORKSGENERALIZEDPREDICTIVECONTROLSUPERHEATEDSTEAMTEMPERATURE1INTRODUCTIONCONTINUOUSPROCESSINPOWERPLANTANDPOWERSTATIONARECOMPLEXSYSTEMSCHARACTERIZEDBYNONLINEARITY,UNCERTAINTYANDLOADDISTURBANCE1,2THESUPERHEATERISANIMPORTANTPARTOFTHESTEAMGENERATIONPROCESSINTHEBOILERTURBINESYSTEM,WHERESTEAMISSUPERHEATEDBEFOREENTERINGTHETURBINETHATDRIVESTHEGENERATORCONTROLLINGSUPERHEATEDSTEAMTEMPERATUREISNOTONLYTECHNICALLYCHALLENGING,BUTALSOECONOMICALLYIMPORTANT3FROMFIG1,THESTEAMGENERATEDFROMTHEBOILERDRUMPASSESTHROUGHTHELOWTEMPERATURESUPERHEATERBEFOREITENTERSTHERADIANTTYPEPLATENSUPERHEATERWATERISSPRAYEDONTOTHESTEAMTOCONTROLTHESUPERHEATEDSTEAMTEMPERATUREINBOTHTHELOWANDHIGHTEMPERATURESUPERHEATERSPROPERCONTROLOFTHESUPERHEATEDSTEAMTEMPERATUREISEXTREMELYIMPORTANTTOENSURETHEOVERALLEFFICIENCYANDSAFETYOFTHEPOWERPLANTITISUNDESIRABLETHATTHESTEAMTEMPERATUREISTOOHIGH,ASITCANDAMAGETHESUPERHEATERANDTHEHIGHPRESSURETURBINE,ORTOOLOW,ASITWILLLOWERTHEEFFICIENCYOFTHEPOWERPLANTITISALSOIMPORTANTTOREDUCETHETEMPERATUREFLUCTUATIONSINSIDETHESUPERHEATER,ASITHELPSTOMINIMIZEMECHANICALSTRESSTHATCAUSESMICROCRACKSINTHEUNIT,INORDERTOPROLONGTHELIFEOFTHEUNITANDTOREDUCEMAINTENANCECOSTSASTHEGPCISDERIVEDBYMINIMIZINGTHESEFLUCTUATIONS,ITISAMONGSTTHECONTROLLERSTHATAREMOSTSUITABLEFORACHIEVINGTHISGOALTHEMULTIVARIABLEMULTISTEPADAPTIVEREGULATORHASBEENAPPLIEDTOCONTROLTHESUPERHEATEDSTEAMTEMPERATUREINA150T/HBOILER3,ANDGENERALIZEDPREDICTIVECONTROLWASPROPOSEDTOCONTROLTHESTEAMTEMPERATURE4ANONLINEARLONGRANGEPREDICTIVECONTROLLERBASEDONNEURALNETWORKSISDEVELOPEDIN5TOCONTROLTHEMAINSTEAMTEMPERATUREANDPRESSURE,ANDTHEREHEATEDSTEAMTEMPERATUREATSEVERALOPERATINGLEVELSTHECONTROLOFTHEMAINSTEAMPRESSUREANDTEMPERATUREBASEDONANONLINEARMODELTHATCONSISTSOFNONLINEARSTATICCONSTANTSANDLINEARDYNAMICSISPRESENTEDIN6FIG1THEBOILERANDSUPERHEATERSTEAMGENERATIONPROCESSFUZZYLOGICISCAPABLEOFINCORPORATINGHUMANEXPERIENCESVIATHEFUZZYRULESNEVERTHELESS,THEDESIGNOFFUZZYLOGICCONTROLLERSISSOMEHOWTIMECONSUMING,ASTHEFUZZYRULESAREOFTENOBTAINEDBYTRIALSANDERRORSINCONTRAST,NEURALNETWORKSNOTONLYHAVETHEABILITYTOAPPROXIMATENONLINEARFUNCTIONSWITHARBITRARYACCURACY,THEYCANALSOBETRAINEDFROMEXPERIMENTALDATATHENEUROFUZZYNETWORKSNFNSDEVELOPEDRECENTLYHAVETHEADVANTAGESOFMODELTRANSPARENCYOFFUZZYLOGIC,ANDLEARNINGCAPABILITYOFNEURALNETWORKS7THENFNSHAVEBEENUSEDTODEVELOPSELFRECEIVED14OCTOBER2005REVISED14OCTOBER2006THISWORKWASSUPPORTEDBYTHENATURALSCIENCEFOUNDATIONOFBEIJINGNO4062030,NATIONALNATURALSCIENCEFOUNDATIONOFCHINANO50576022,69804003,SCIENTIFICRESEARCHCOMMONPROGRAMOFBEIJINGMUNICIPALCOMMISSIONOFEDUCATIONKM200611232007XLIUETAL/JOURNALOFCONTROLTHEORYANDAPPLICATIONS20075183–88853NEUROFUZZYNETWORKGENERALIZEDPREDICTIVECONTROLTHEGPCISOBTAINEDBYMINIMIZINGTHEFOLLOWINGCOSTFUNCTION10,JEN?JDQJ?YTJ?YRTJ2M?J1ΛJΔUTJ?12,7WHEREQJANDΛJARERESPECTIVELYTHEWEIGHTINGFACTORSFORTHEPREDICTIONERRORANDTHECONTROL,YRTJISTHEJTHSTEPAHEADREFERENCETRAJECTORY,DISTHEMINIMUMCOSTINGHORIZON,NANDMARERESPECTIVELYTHEMAXIMUMCOSTINGHORIZONFORTHEPREDICTIONERRORANDTHECONTROLTHECONTROLCOMPUTEDFROMTHENFGPCISTHEWEIGHTEDSUMOFTHECONTROLOBTAINEDFROMPLOCALGPCCONTROLLERSΔUTP?I1ΑIΔUIT,8WHEREΔUITISTHECONTROLINTHEITHREGION,ΑIXISDEFINEDPREVIOUSLYIN4NOTETHATTHEWEIGHTSINTHENFGPCAREIDENTICALTOTHATINTHENFNTHATMODELSTHEPROCESSSINCESWITCHINGBETWEENLOCALGPCCONTROLLERSINTHENFGPCINVOLVESFUZZYLOGICS,ITCANBEINTERPRETEDNOTONLYASAFUZZYCONTROLLER,BUTALSOASAFUZZYSUPERVISORTHECONTROLCANBESMOOTHIFTHEWEIGHTSΑIXARESUITABLYSELECTEDFROMTHENFN6ANDTHECONTROL8,JGIVENBY7CANBEREWRITTENASJEN?JDQJP?I1ΑI?YITJ?YRTJ2M?J1ΛJP?I1ΑIΔUITJ?129THECOSTFUNCTIONISSIMPLIFIEDFIRSTUSINGTHECAUCHYINEQUALITYSINCEP?I1ΑI?YITJ?YRTJ2?PP?I1ΑI?YITJ?YRTJ2,HENCEP?I1ΑIΔUITJ?12?PP?I1ΑIΔUITJ?1210EQUATION10IMPLIESTHATTHESUMOFTHEWEIGHTEDSQUAREDERRORSCANBEANUPPERBOUNDOFTHECOSTFUNCTIONJREWRITING9GIVESEN?JDP?I1QJΑI?YTJ?YRTJ2M?J1P?I1ΛJΑIΔUITJ?12EP?I1ΑI2N?JDQJ?YITJ?YRTJ2P?I1ΑI2M?J1ΛJΔUITJ?12P?I1ΑI2JI,11WHEREJIEN?JDQJ?YITJ?YRTJ2M?J1ΛJΔUITJ?1212EQUATION11SHOWSTHATMINIMIZINGJIISESSENTIALLYTHESAMEASTHATOFMINIMIZINGJFROM12,ASETOFLOCALGENERALIZEDPREDICTIVECONTROLLERSISOBTAINED,WHICHFORMSPARTOFTHENFGPCTHELOCALGPC10ISGIVENBY,ΔUITGTIQIGIΛI(xiàn)?1GTIQIYRT1?FIΔUIT?1?SIZ?1YIT,13WHEREYRT1?YRT1,?YRT2,,?YRTNT,ΔUITΔUIT,ΔUIT1,,ΔUITM?1T,ΔUIT?1ΔUIT?NB,ΔUIT?NB1,,ΔUIT?1T,SIZ?1SI1Z?1,SI2Z?1,,SINZ?1TSIZ?1ANDRIZ?1SATISFYTHEDIOPHANTINEEQUATION1ˉAIZ?1RIJZ?1Z?JSIJZ?1,14ANDGIJZ?1BIZ?1RIJZ?1GIJ,0GIJ,1Z?1GIJ,NBJ?1Z?NBJ?1,15AQIDIAGQI1,QI2,,QIN,15BΛI(xiàn)DIAGΛI(xiàn)1,ΛI(xiàn)2,,ΛI(xiàn)M,15CGTI???????GI1,0GI2,1GIN,N?1GI1,0GIN?1,N?20GIN?M1,N?M???????,15DFI???????GI1,NBGI1,NB?1GI1,2GI1,1GI2,NB1GI2,NBGI2,3GI2,2GIN,NBN?1GIN,NBN?2GIN,N1GIN,N???????15ETHEOPTIMIZEDMSTEPSAHEADCONTROLISCOMPUTED,ANDONLYTHEFIRSTSTEPAHEADCONTROLISIMPLEMENTED,USINGARECEDINGHORIZONPRINCIPLE10,GIVINGΔUITDTI1YRT1?FIΔUIT?1?SIZ?1YIT,16
      下載積分: 10 賞幣
      上傳時(shí)間:2024-03-13
      頁(yè)數(shù): 6
      12人已閱讀
      ( 4 星級(jí))
    • 簡(jiǎn)介:HIGHPERFORMANCECONTROLOFABOOSTACDCPWMRECTIFIERINDUCTIONGENERATORSYSTEMJYOTISASTRY,OLORUNFEMIOJO,ZHIQIAOWUDEPARTMENTOFELECTRICALANDCOMPUTERENGINEERING/CENTERFORENERGYSYSTEMSRESEARCHLABORATORYFORELECTRICMACHINESANDPOWERELECTRONICSTENNESSEETECHNOLOGICALUNIVERSITYCOOKEVILLE,TN38505,USAPHONE9313723869,FAX9313723436,EMAILJOJOTNTECHEDUABSTRACTTHISPAPERPRESENTSACONTROLMETHODOLOGYFORTHEDCVOLTAGEREGULATIONOFANINDUCTIONGENERATORACDCBOOSTRECTIFIERSYSTEMINWHICHTHECOPPERLOSSOFTHEGENERATORISMINIMIZEDWITHTHEAIDOFANINPUTOUTPUTLINEARIZATIONTECHNIQUE,WHICHLINEARIZESANDDECOUPLESTHEMODELEQUATIONSINTHESYNCHRONOUSREFERENCEFRAME,AROTORFLUXVECTORCONTROLTYPEHIGHPERFORMANCEISACHIEVEDSTEADYSTATEANALYSISPROVIDESSOMEINSIGHTSINTOTHEOPERABILITYREGIMEOFTHEGENERATORTHEEFFECTIVENESSOFTHECONTROLSCHEMEUNDERDIFFERENTLOADCONDITIONSASWELLASVARYINGROTORSPEEDSHASBEENDEMONSTRATEDBYCOMPUTERSIMULATIONSSOMEEXPERIMENTALRESULTSAREINCLUDEDINDEXWORDSINDUCTIONGENERATOR,ACDCPWMRECTIFIER,EXCITATION,INPUTOUTPUTLINEARIZATION,BUTTERWORTHPOLYNOMIALS,MAGNETIZINGFLUXSATURATIONIINTRODUCTIONGROWINGRESEARCHANDREALAPPLICATIONINTERESTSINALTERNATIVEENERGYSYSTEMSSUCHASWINDENERGYHASINCREASEDTHEUSEOFTHEINDUCTIONMACHINEASAGENERATORBECAUSEOFINHERENTADVANTAGESOFSUCHASLOWCOST,REDUCEDMAINTENANCE,RUGGEDANDSIMPLECONSTRUCTION,BRUSHLESSROTORSQUIRRELCAGEANDSOONTHEOPERATIONOFANINDUCTIONMACHINEASAMOTORORGENERATORISDETERMINEDBYTHEOPERATINGSLIPOFTHEMACHINEAPOSITIVEOPERATIONALSLIPWOULDINDICATETHEOPERATIONOFTHEMACHINEASAMOTOR,ANDANEGATIVESLIPWOULDINDICATETHEGENERATINGMODEOFTHEMACHINEITISWELLKNOWNTHATANINDUCTIONMACHINECANBEMADETOWORKASASELFEXCITEDGENERATOR,IETHEGENERATORCANBEEXCITEDBYTHEACONNECTIONOFTHREECAPACITORSATTHESTATORTERMINALSOFTHEMACHINEBBYUSINGANINVERTER/RECTIFIERSYSTEM1INTHECASEOFTHEINVERTER/RECTIFIERSYSTEM,THEDCSIDECAPACITORAPPEARSLIKETHREEPHASECAPACITORSDUETOTHESWITCHINGSIGNALSOFTHEINVERTER,ANDTHESINGLEDCCAPACITOROFTHERECTIFIERPROVIDESTHEREQUIREDEXCITATIONFORTHEINDUCTIONGENERATORANEXTENSIVEOVERVIEWILLUSTRATINGTHEVASTAMOUNTOFWORKDONEINDIFFERENTAREASOVERTHELAST25YEARSSUCHASSELFEXCITATION,VOLTAGEBUILDUPMODELING,STEADYSTATEANALYSISOFANINDUCTIONMACHINEHASBEENPRESENTEDIN2ALSO,INPREVIOUSLYPUBLISHEDWORK,THEVECTORCONTROLOFTHEINDUCTIONGENERATORRECTIFIERSYSTEMTOPRODUCEDCPOWERINWHICHTHERECTIFIERALSOPROVIDESTHEEXCITATIONHASBEENREPORTED3THESYSTEMHASBEENSTUDIEDSPECIFICALLYFORAPPLICATIONSRELATEDTOWINDENERGY,THEREBYSTUDYINGTHECONTROLLERRESPONSEFORVARYINGROTORSPEEDSALSOTHESTABILITYOFANINDUCTIONGENERATORRECTIFIERUNDERFIELDORIENTATIONCONTROLHASBEENSTUDIEDIN4,HIGHLIGHTINGTHEPOSSIBLEINSTABILITYOFANINDUCTIONGENERATORUSEDINHIGHSPEEDAPPLICATIONSTHECONTROLMETHODADOPTEDINTHISPAPERHASBEENLAIDOUTINDETAIL,ILLUSTRATINGTHEINPUTOUTPUTLINEARIZATIONMETHODUSEDINSEPARATINGTHELINEARFROMTHENONLINEARTERMSINTHESYSTEMMODELEQUATIONSTHEPROPOSEDCONTROLSCHEMEHASBEENTESTEDFORITSEFFECTIVENESSBYVARYINGLOADCONDITIONSASWELLASVARYINGTHEROTORSPEEDOFTHEMACHINETHEMACHINEHASBEENOPERATEDATACONDITIONOFMINIMUMCOPPERLOSS5THECONDITIONOFMINIMUMLOSSISACHIEVEDBYREGULATINGTHECOMMANDROTORFLUXUSINGALOSSMINIMIZATIONFUNCTIONTHESTEADYSTATEANALYSISDEALSWITHTHEOPERATIONOFTHESELFEXCITEDGENERATORUNDERCONDITIONSOFSATURATION6THEINDUCTIONMACHINEHASBEENSTUDIEDFORITSOUTPUTPOWERCAPABILITYANDTHEEFFECTOFTHEPARAMETERSOFTHEMACHINEONTHEOPERATIONOFTHEMACHINEUNDERDIFFERENTLOADCONDITIONSTHEANALYSISINTHISPAPERAIMSATHIGHLIGHTINGTHEEFFECTOFTHEMAGNETIZINGFLUXONTHEEXCITATIONREQUIREMENTSOFTHESYSTEMWITHTHEMAGNITUDEOFTHEMODULATIONSIGNALASAMEASUREOFTHEREQUIREDEXCITATIONBYFIXINGTHEMAGNETIZINGFLUXLINKAGETHEREQUIREDMODULATIONINDEXFOREXCITATIONOFTHEMACHINECANBEDETERMINEDALONGWITHTHEEFFECTOFSATURATION,THESYSTEMHASBEENSTUDIEDUNDERACONDITIONOFMINIMUMCOPPERLOSSTHEORGANIZATIONOFTHISPAPERISASFOLLOWSSECTIONSIIANDIIIDETAILTHEMODELSOFTHETHREEPHASEBOOSTRECTIFIERANDINDUCTIONGENERATORRESPECTIVELYTHEMODELOFTHECOMBINEDSYSTEMHASALSOBEENINCLUDEDINSECTIONIIISECTIONIVDEALSWITHTHESTEADYSTATEANALYSISOFTHEIAS200510070780392086/05/2000?2005IEEEIAS200510070780392086/05/2000?2005IEEETHEEFFECTOFMAGNETICAIRGAPFLUXLINKAGESATURATIONISTAKENINTOACCOUNT6THEANALYSISAIMSATDETERMININGTHEVALUEOFTHEMAGNITUDEOFTHEMODULATIONINDEXREQUIREDFORTHEEXCITATIONOFTHEGENERATOR,TAKINGINTOACCOUNTTHEEFFECTOFSATURATIONANDACONDITIONOFMINIMUMTOTALCOPPERLOSSINTHEMACHINEUNDERSATURATEDCONDITIONS,THEMAGNETIZINGINDUCTANCEVARIESWITHTHEMAGNETIZINGFLUXASSHOWNINFIGURE2FORA2HPINDUCTIONMACHINETHEREFERENCEFRAMETRANSFORMATIONANGLEOFTHEVOLTAGEEQUATIONSASSUMESTHEALIGNMENTOFTHEQAXISWITHTHEMAGNETIZINGFLUXLINKAGEHENCE,THEDAXISMAGNETIZINGFLUXISASSUMEDTOBEZERO,ANDTHEDAXISMAGNETIZINGINDUCTANCEISCONSTANTHOWEVERTHEQAXISMAGNETIZINGINDUCTANCEISAFUNCTIONOFTHEMAGNETIZINGFLUX,WHICHISAPPROXIMATEDBYAPOLYNOMIALGIVENIN1326871154754181MMMQLΛΛ?13QDRSQDSSSDCQDSBPJTVMΛΛΩ??214QDSRQDRSRBPJTΛΛΩ?015LDCQSQDSDCRVIMALCPV?RE2316WHEREΩSISTHESLIPFREQUENCYDEFINEDASRESΩΩΩ?DLRTRSSDLRBMRR?DLRTSRRDLRBMSS?2MRSLLLD?FIG2VARIATIONOFTHERECIPROCALOFTHEMAGNETIZINGINDUCTANCEWITHTHEMAGNETIZINGFLUXDURINGSTEADYSTATE,THEDERIVATIVES,PIN1416AREZEROALONGWITHACCOUNTINGFORMAGNETICSATURATIONOFTHEAIRGAPFLUXLINKAGEINTHEMACHINE,THEANALYSISAIMSATTHEOPERATIONOFTHEMACHINEATMINIMUMTOTALCOPPERLOSSTHETOTALCOPPERLOSS17INTHEMACHINEISMINIMUM,WHENITSDERIVATIVEWITHTHEROTORSLIPISZEROTHISCONDITIONISACHIEVEDBYAPPROPRIATESELECTIONOFTHEOPERATINGSLIPOFTHEMACHINE,GIVENBYEQUATION18THESLIPISPLOTTEDASAFUNCTIONOFTHEMAGNETIZINGINDUCTANCEINFIGURE3FIG3VARIATIONOFTHESLIPWITHTHEMAGNETIZINGFLUX2222LOSSCOPPER23DRQRRDSQSSIIRIIRP17112222MAX??MRRSRSRLRLRRRSΩ18TOOBTAINARELATIONSHIPBETWEENTHEMAGNITUDEOFTHEMODULATIONINDEXMANDTHEMAGNETIZINGFLUX,THESTATORCURRENTSINEQUATION16AREEXPRESSEDINTERMSOFTHESTATORFLUXESREARRANGINGEQUATION15QDSSRRQDRJTBΛΩΛ??19SUBSTITUTINGEQUATION19IN14?????????SRRSESDCQDSQDSJTBBJTVMΩΩΛ220THESTATORCURRENTSCANBEEXPRESSEDINTERMSOFTHESTATORFLUXESASQDSSRMRRQDSJTDLBDLIΛΩ???????21SUBSTITUTING20IN21ANDELIMINATINGTHESTATORCURRENTSIN16,23221REMRJTBBJTJTDLBDLALLSRRSESSRMRR???????????????????????????????ΩΩΩ22USINGEQUATION22THEEFFECTOFTHECHANGINGMAGNETIZINGFLUXONTHEMAGNITUDEOFTHEMODULATIONINDEXISOBTAINEDUNDERACONDITIONOFMINIMUMCOPPERLOSSTHEMAGNETIZINGFLUXLINKAGEISVARIEDANDTHECORRESPONDINGVALUESOFMAGNETIZINGINDUCTANCESARECALCULATEDUSINGTHEVALUESOFTHEMAGNETIZINGINDUCTANCES,THESLIPANDTHECORRESPONDINGMODULATIONINDEXISCALCULATEDFORMINIMUMIAS200510090780392086/05/2000?2005IEEEIAS200510090780392086/05/2000?2005IEEE
      下載積分: 10 賞幣
      上傳時(shí)間:2024-03-14
      頁(yè)數(shù): 8
      10人已閱讀
      ( 4 星級(jí))
    • 簡(jiǎn)介:關(guān)于SBS改性瀝青配合比設(shè)計(jì)及施工技術(shù)的探討摘要在良好的設(shè)計(jì)配合比和施工條件下,SBS瀝青能使瀝青路面的耐久性和高溫穩(wěn)定性明顯提高。本文將根據(jù)南二路的施工試驗(yàn)情況,簡(jiǎn)要講述SBS改性瀝青的施工技術(shù)要求。一、SBS改性瀝青概述SBS改性瀝青是在原有基質(zhì)瀝青(AH70)的基礎(chǔ)上,摻加25、30、40%的SBS改性劑,改性后的瀝青,與原瀝青相比,其高溫粘度增大,軟化點(diǎn)升高。在良好的設(shè)計(jì)配合比和施工條件下,瀝青路面的耐久性和高溫穩(wěn)定性明顯提高。在SBS改性瀝青生產(chǎn)過(guò)程中進(jìn)行了大量的室內(nèi)試驗(yàn),生產(chǎn)后對(duì)其技術(shù)指標(biāo)進(jìn)行了現(xiàn)場(chǎng)實(shí)驗(yàn),實(shí)驗(yàn)結(jié)果表明,外摻30SBS的改性瀝青,軟化點(diǎn)、針入度等指標(biāo)均滿足改性瀝青規(guī)范要求,可用SBS改性瀝青做瀝青混合料的配合比設(shè)計(jì)。二、SBS瀝青混合料的配合比設(shè)計(jì)為了使設(shè)計(jì)的混合料能夠達(dá)到實(shí)施效果,需要從材料要求、施工工藝、質(zhì)量控制標(biāo)準(zhǔn)和質(zhì)量控制方法等諸多方面提出以下要求,希望能夠引起注意。(一)、原材料要求11粗集料用于改性瀝青混合料面層的粗集料,宜采用碎石或碎礫石,其粒徑規(guī)格和質(zhì)量要求均應(yīng)符合公路瀝青路面施工技術(shù)規(guī)范(JTJ03294)的規(guī)定1粗集料應(yīng)潔凈、干燥、無(wú)風(fēng)化、無(wú)有害雜質(zhì),且具有一定硬度和強(qiáng)度。2粗集料應(yīng)具有良好的顆粒形狀,破碎礫石用于高速公路、一級(jí)公路時(shí),應(yīng)采用大礫石破碎,并至少應(yīng)有兩個(gè)以上的破碎面。3、對(duì)于抗滑表層粗集料應(yīng)選擇硬質(zhì)巖(中性或基性火成巖)。由于硬質(zhì)巖石與瀝青的粘接力存在著較大差異,粗集料與瀝青的粘附性應(yīng)不小于4級(jí)。對(duì)于3-5MM石屑部分由于含量較低,并且該部分對(duì)瀝青混合料形成嵌接結(jié)構(gòu)有一定的作用,建議用硬質(zhì)巖石屑(玄武巖)。12細(xì)集料細(xì)集料包括人工砂、天然砂。瀝青路面面層宜采用人工砂作為細(xì)集料,細(xì)集料應(yīng)潔凈、干燥、無(wú)風(fēng)化、無(wú)有害雜質(zhì),有適當(dāng)?shù)念w粒組成,并與改性瀝青有良好的粘附性,天然砂由于質(zhì)量變化大(大部分為中粗砂),形狀較圓滑,與瀝青的粘附性差,對(duì)瀝青混合料影響較大。對(duì)于高速公路、一級(jí)公路瀝青混合料,天然砂的含量不宜超過(guò)20%,可用03MM的石屑粉代替天然砂。13填充料施1、采用“瀝青混合料馬歇爾穩(wěn)定度試驗(yàn)”方法測(cè)定的48H浸水馬歇爾穩(wěn)定度試驗(yàn)殘留穩(wěn)定度不應(yīng)小于80。(2)、采用“瀝青混合料凍融劈裂試驗(yàn)”方法測(cè)定的劈裂強(qiáng)度比不應(yīng)小于80。三、SBS瀝青混合料的施工SBS瀝青是一種以彈性塑膠類改性瀝青,正確使用可以顯著提高瀝青面層的抗車轍性能,增加耐久性,增加抗老化能力,延長(zhǎng)公路的壽命。與AH70基質(zhì)瀝青相比,SBS瀝青的粘度和軟化點(diǎn)顯著增加,SBS瀝青的運(yùn)輸儲(chǔ)存和路面面層施工有一些與基質(zhì)瀝青不同的要求,只有正確使用才能達(dá)到預(yù)期效果。1、拌合、運(yùn)輸?shù)募夹g(shù)要求為保證瀝青混合料的質(zhì)量更穩(wěn)定,瀝青用量更準(zhǔn)確,宜采用間隙式拌和機(jī)拌和。拌和必須均勻,只有SBS瀝青改性劑完全分散在瀝青中,才能充分發(fā)揮其效能,對(duì)于密級(jí)配(AC13I)混合料,應(yīng)做到拌合后的混合料均勻一致,無(wú)細(xì)料和粗料分離及花白、結(jié)成團(tuán)塊的現(xiàn)象。由于SBS改性瀝青混合料的施工溫度要求較高,建議拌合溫度控制在160℃,運(yùn)輸車必須加蓋篷布或其它保溫材料,防止結(jié)合料表面結(jié)硬,為確保攤鋪連續(xù)以及平整度大小符合技術(shù)規(guī)范要求,必須保證攤鋪機(jī)前至少兩輛車等待卸料,決不能出現(xiàn)攤鋪機(jī)等車的現(xiàn)象。其余要求應(yīng)滿足改性瀝青路面施工技術(shù)規(guī)范的技術(shù)要求。2、攤鋪的技術(shù)要求SBS瀝青混合料在攤鋪時(shí)應(yīng)盡量連續(xù)不斷的施工,以減少攤鋪機(jī)和壓路機(jī)的停頓,應(yīng)盡量減少橫縫,提高其面層平整度。為提高路面的平整度,表面層宜采用攤鋪前后保持相同高差的雪橇式攤鋪厚度控制方式。由于SBS瀝青粘度較大,粘附力強(qiáng),用部分?jǐn)備仚C(jī)的后雪橇是膠輪式結(jié)構(gòu),膠輪易粘附混合料細(xì)顆粒,影響平整度,所以攤鋪機(jī)后雪橇是膠輪式結(jié)構(gòu)的必須改成鋼滑靴式結(jié)構(gòu)。攤鋪速度應(yīng)控制在2米/分鐘,做到緩慢、均勻、連續(xù)不間斷地?cái)備?,禁止隨意變換速度或中途停頓。提高攤鋪過(guò)程中的預(yù)壓密實(shí)度。改性瀝青SBS混合料在高溫狀態(tài)下主要是靠粗集料的嵌擠作用,可適當(dāng)提高夯錘振搗頻率,使剩余壓實(shí)系數(shù)減少,初壓的痕跡也極小,進(jìn)而確保路面的最終平整度。3、碾壓的技術(shù)要求對(duì)于密級(jí)配型混合料,其適宜的碾壓溫度范圍是130℃-150℃,其最終碾壓溫度不低于110℃。SBS瀝青混合料的壓實(shí)工藝本著以下原則進(jìn)行按照“緊跟、慢壓、高頻、低幅”“碾壓八字方針進(jìn)行碾壓,壓路機(jī)必須緊跟攤鋪機(jī)的后面,只有在高溫條件下碾壓才能取得更好的效果,壓實(shí)速度控制在4-5KM/H。碾壓速度均衡,倒退時(shí)關(guān)閉振動(dòng),方向要逐漸地改變,不許擰著彎行走,對(duì)每一道碾壓起點(diǎn)或終點(diǎn)可稍微扭彎碾壓,消除碾壓接頭輪跡。決不允許
      下載積分: 10 賞幣
      上傳時(shí)間:2024-03-16
      頁(yè)數(shù): 10
      14人已閱讀
      ( 4 星級(jí))
    • 簡(jiǎn)介:中文中文4480字畢業(yè)設(shè)計(jì)外文資料翻譯畢業(yè)設(shè)計(jì)外文資料翻譯題目環(huán)氧樹脂的力學(xué)性能學(xué)院材料科學(xué)與工程專業(yè)復(fù)合材料與工程班級(jí)學(xué)生學(xué)號(hào)20060103027指導(dǎo)教師指導(dǎo)教師二〇一〇年三月二十日2脂塑性變形的后固化溫度對(duì)塑性變形的影響,并且解釋了各個(gè)理論的各個(gè)條款,發(fā)展到能解釋玻璃狀聚合物的塑性變形。在第二部分我們展示了在這些材料中的裂紋擴(kuò)展是受樹脂的塑性變形行為控制。2實(shí)驗(yàn)過(guò)程21成型和制樣目前此研究用的樹脂是一個(gè)商用雙酚A二縮水甘油醚(DGEBA),與EPIKOTE828(殼牌)的三乙烯四胺(TETA),經(jīng)過(guò)初級(jí)混合得到二級(jí)胺。成型條件的詳細(xì)內(nèi)容被記載到以前的出版物上1113。固化劑使用的四種不同的數(shù)量是74,98,123和147每份。對(duì)于所有的初始硬化成型反應(yīng)可以在不同時(shí)期高溫固化前在室溫下反應(yīng)24小時(shí)。鑄造樹脂在形式上有兩種不同的厚度39和63RAM。22楊氏模量的測(cè)定把39MM的模壓樹脂片切成30MM70RAM的矩形片。樹脂的系數(shù)由三點(diǎn)彎曲確定,用一款英斯特機(jī)械測(cè)試機(jī)作用在不同的跨桿頭速度下得到。圖解說(shuō)明如圖1A。載荷P和試樣中心位移Y的關(guān)系體現(xiàn)在圖1B。而且P與Y的比值通過(guò)方程與樹脂的楊氏模量有關(guān)14,式中的B和H分別是試樣矩形截面的寬度和厚度。兩個(gè)支撐點(diǎn)之間的距離是L樹脂的模量是E。位移Y取決于跨頭的運(yùn)動(dòng),同時(shí)要考慮到機(jī)器的柔韌性。圖1楊氏模量的確定A三點(diǎn)彎曲測(cè)試B載荷位移曲線。23屈服應(yīng)力的測(cè)量用63毫米的樹脂板加工的長(zhǎng)10毫米直徑5毫米的圓柱樣本,他們?cè)诃h(huán)境室的英斯特朗測(cè)試機(jī)的拋光潤(rùn)滑板之間發(fā)生單軸壓縮變形如圖2A。公稱應(yīng)變E取決于
      下載積分: 10 賞幣
      上傳時(shí)間:2024-03-17
      頁(yè)數(shù): 13
      19人已閱讀
      ( 4 星級(jí))
    • 簡(jiǎn)介:字?jǐn)?shù)英文字?jǐn)?shù)英文23352335單詞,單詞,1305713057字符;中文字符;中文39063906漢字漢字作者及出處作者及出處KOLCHEDANTSEVKOLCHEDANTSEVL,L,ADAMTSEVICHADAMTSEVICHA,A,STUPAKOVASTUPAKOVAO,O,ETETALALMEASURESMEASURESTOTOREDUCEREDUCECONSTRUCTIONCONSTRUCTIONTIMETIMEOFOFHIGHRISEHIGHRISEBUILDINGSC//E3SBUILDINGSC//E3SWEBWEBOFOFCONFERENCESEDPCONFERENCESEDPSCIENCES,2018,3303062SCIENCES,2018,3303062外文文獻(xiàn)外文文獻(xiàn)MEASURESTOREDUCECONSTRUCTIONTIMEOFHIGHRISEBUILDINGSABSTRACTTHEORGANIZATIONALANDTECHNOLOGICALSOLUTIONSFORHIGHRISEBUILDINGSCONSTRUCTIONEFFICIENCYINCREASEARECONSIDERED,PRIMARILY–DECREASEOFTYPICALFLOORCONSTRUCTIONTIMEANDIMPROVEMENTOFBEARINGSTRUCTURESCONCRETEQUALITYTHEESSENCEOFOFFEREDTECHNOLOGYISACONCRETEMIXINGSTATIONANDAPOLYGONMAINLYFORLOADBEARINGWALLPANELSWITHSTARTERBARSCASTINGARELOCATEDONTHEBUILDINGSITEFORREINFORCEDCONCRETECOMPONENTSMANUFACTURINGANDBUTTJOINTSGROUTINGTHEWARMEDUPCONCRETEMIXTURESAREUSEDTHERESULTSOFRESEARCHESANDELABORATIONSCARRIEDOUTBYTHESPSUACEINAREAOFAPRELIMINARYWARMINGUPOFCONCRETEMIXTURESAREPRESENTEDTHEPOSSIBILITYANDFEASIBILITYOFTHEIRUSAGEINHIGHRISEBUILDINGSANDOFEXCESSHEIGHTBUILDINGSCONSTRUCTIONINCLUDINGCASTINPLACEANDPRECASTEXECUTIONARESHOWNTHEESSENCEOFHEATVIBROTREATINGOFCONCRETEMIXTUREISREVEALEDASAKINDOFPRIORELECTRORESISTIVECURING,ANDTHEACHIEVEDRESULTSAREACCELERATEDCONCRETESTRENGTHGAIN,POWERINPUTSDECREASE,CONCRETEQUALITYIMPROVEMENTITISSHOWNTHATTHELOCATIONOFACONCRETEMIXINGSTATIONONTHEBUILDINGSITEENABLESTOBROADENPOSSIBILITIESOFTHE“THERMOS”METHODUSEANDTOAVOIDCONCRETEMIXTURESWARMINGUPINMEDIUMMASSSTRUCTURESERECTIONCOLUMNS,GIRDERSDURINGTHEHIGHRISEBUILDINGSCONSTRUCTIONITISEXPERIMENTALLYPROVEDTHATTHESPLICEBETWEENPRECASTELEMENTSENCASEDWITHWARMEDUPCONCRETEMIXTUREISEQUALWITHCONJUGATEDELEMENTSINSTRENGTHCONSTRUCTIONINHIGHRISESBUILDINGMENTIONEDPARAMETERSOFCONCRETEPHYSICALANDMECHANICALPROPERTIESAREESTIMATEDRELATIVELYRELATIVECOMPRESSIVE,TENSILE,BENDINGSTRENGTH,ETC,WHATGIVESTHEOPPORTUNITYTOAPPLYTHELABANDFIELDTESTSRESULTSTOCONCRETESOFDIFFERENTCLASSESINADDITIONTOTRADITIONALGOSTOVSKAYATECHNIQUES,FOREXAMPLE,GOST1018090CONCRETEMETHODSOFDETERMININGSTRENGTHONTESTSPECIMENS,FORTESTOFJOINTOFPRECASTMONOLITHICBUILDINGSWASDESIGNEDBYASPECIALTECHNIQUEONACTIVEAREAOFTHE“OLD”CONCRETEWHICHARETHEENDSOFCOMBINEDPANELSTHEVERTICALINCLINEDCHASES4MMWIDEAND6MMDEPTHWEREMADETHECONCRETEMIXTUREOF“NEW“CONCRETEWASWARMEDUPJUSTBEFORETHEPLACINGWITHALTERNATEELECTRICCURRENTOFINDUSTRIALFREQUENCY50HZTO500СAND700СTEMPERATUREANDTHENPLACEDWITHVIBRATIONINSPLICECAVITYFOR“OLD“AND“NEW“CONCRETESSAMPLESSHEARTESTINGPOSTGRADUATESTUDENTMUSTAFINRRCREATEDSPECIALMETHODEXCLUDESTHEAPPEARANCEOFTHETORSIONALMOMENTABOUT“OLD“AND“NEW“CONCRETESCONTACTPLANETHEESSENCEOFCONCRETEMIXTURETHERMALTREATMENTTHATISAKINDOFAPRELIMINARYWARMINGUP,ITSRATIONALAPPLICATIONFIELD,USEDMATERIALS,ANDTHEACHIEVEDEFFECTAREPRESENTEDINWRITINGITISIMPORTANTTONOTEHERETHATONLYAPPLICATIONOFWARMEDUPCONCRETEMIXTURESMADEATSITEPOLYGONENABLESTOGETCONCRETETRANSPORTSTRENGTHINMINIMUMTIMEWITHMINIMUMPOWERINPUTSANDREQUIREDCONCRETEQUALITYPROVIDEDTHEGROUTINGOFBUTTJOINTSBETWEENPRECASTELEMENTSWITHWARMEDUPMIXTUREPROVIDESTHEEQUALITYINSTRENGTHOFTHEJOINTANDCONJUGATEDELEMENTSTHEFEASIBILITYOFACONCRETEMIXINGSTATIONLOCATIONONASITEOFAHIGHRISEBUILDINGCONSTRUCTION,ITSPARAMETERSARESUBSTANTIATEDINWRITINGS3RESULTS31THEMOBILECONCRETEMIXINGSTATIONCMSLOCATIONONHIGHRISEBUILDINGSITE
      下載積分: 10 賞幣
      上傳時(shí)間:2024-03-11
      頁(yè)數(shù): 21
      13人已閱讀
      ( 4 星級(jí))
    關(guān)于我們 - 網(wǎng)站聲明 - 網(wǎng)站地圖 - 資源地圖 - 友情鏈接 - 網(wǎng)站客服客服 - 聯(lián)系我們

    機(jī)械圖紙?jiān)创a,實(shí)習(xí)報(bào)告等文檔下載

    備案號(hào):浙ICP備20018660號(hào)