殼聚糖—坡縷石—聚乙烯醇三元復合膜的制備及其對伊維菌素的緩釋行為.pdf

1、目錄摘要.......................................................................................................................................IABSTRACT........................................................................

2、.....................................................II第一章第一章緩、控釋藥物載體研究進展緩、控釋藥物載體研究進展......................................................................................11.1緩、控釋制劑概念.....................................

3、....................................................................11.2緩、控釋制劑在治療上的特點.....................................................................................21.2.1減少給藥次數(shù)......................................

4、....................................................................21.2.2提高藥物的安全性和有效性..................................................................................21.2.3減小對腸胃的刺激......................................

5、............................................................21.2.4增強藥物化學穩(wěn)定性..............................................................................................21.3緩、控釋制劑的釋藥機理....................................

6、.........................................................21.3.1溶出原理..................................................................................................................21.3.2材料降解控制釋放.........................

7、.........................................................................31.3.3溶蝕原理..................................................................................................................31.3.4擴散原理.............

8、.....................................................................................................41.3.5溶蝕與溶出、擴散相結(jié)合......................................................................................51.3.6其他原理......

9、............................................................................................................51.4緩釋藥物常用載體....................................................................................................

10、.....61.4.1根據(jù)材料來源分類..................................................................................................61.4.2根據(jù)生物降解性能分類.......................................................................................

11、.111.4.3多元復合藥物緩釋材料........................................................................................121.5緩釋藥物體系類型及其制備方法...............................................................................141.5.1納米粒子.....

12、...........................................................................................................141.5.2微球........................................................................................................

13、................151.5.3片............................................................................................................................151.5.4膜................................................................

14、............................................................151.5.5固體分散體............................................................................................................161.6本研究的選題目的、意義與內(nèi)容.....................