上皮鈣黏素、β-連環(huán)素和Ki-67在膀胱癌的表達及其生物學(xué)意義.pdf

1、青島大學(xué)碩士學(xué)位論文上皮鈣黏素、β連環(huán)素和Ki67在膀胱癌的表達及其生物學(xué)意義姓名：代新年申請學(xué)位級別：碩士專業(yè)：病理學(xué)指導(dǎo)教師：紀祥瑞20051126TheexpressionofEcadherin、6cateninandKi一67inbladdertransitionalcellcarcinomaanditssignificanceCandidateformaster：DaiXinnianSupervisor：JiXiangruiD

2、epartmentofpathology，AffiliatedhospitalofMedicalCollegeofQingdaoUniversityQingdao266003，ChinaAbstractObjeetiveToinvestigatethepossiblerelationshipbetweenE—cadherinfE—cad)、D—catenin(13cat)andKi一67expressioninbladdertransi

3、tionalcellcarcinoma(BTCC)anditspathologicalgradeandclinicalstage，MethodsAnimmunohistochemicalmethodwasusedtoexaminetheexpressionofEcad、13catandKi一67in73paraffin—embeddedurinarybladdertransitionalcellcarcinomaspecimensRes

4、ultsTheabnormalexpressionratesofE—cadand3catandKi67inpathologicGradeI，GradeIIandGrade111were19O％(4／21)，515％(17／33)，842％(16／19)and19O％(4／21)，455％(15／33)，89，5％(17／19)and143％(3／21)，424％(14／33)，842％(16／19)respectivelyTheabno

5、rmalexpressionratesinTis—T1andT2一T4were256％(10／39)，794％(27／34)and333％(13／39)，676％(23／34)and23I％(9／39)，706％(24／34)respectivelyIncomparisonbetweentheabovedata，thedifferenceswerestatisticallysignificantfallthePvalueswereO05

6、)TherewasclosecorrelationbetweenEcadandki67expressionandcorrelationwasstatisticallysignificantConclusionTheexpressionofE—cad、B—cataresignificantlowerandKi一67issignificanthigherinBTCCTheaberrantexpressionofEcad、13cat、ki67