香豆素類金屬離子探針的設(shè)計、合成及性能研究.pdf

1、博士學(xué)位論文IfUFJFIrlfliilJrIJJll!frrlfili!lljJ蚴刪ⅢY1532006香豆素類金屬離子探針的設(shè)計、合成及性能研究CoumarinbasedProbesforMetalIons：MolecularDesign，SynthesisandProperties一級學(xué)科：學(xué)科專業(yè)：研究生：指導(dǎo)教師：化學(xué)有機(jī)化學(xué)扈靖張明杰教授張文勤教授天津大學(xué)理學(xué)院二零零八年八月ABSTRACTAseriesofprobeswit

2、hvariousreceptorSattachedtocoumarinfluorophoresweredesignedforthedetectionofmetalionsTheirsensitivitytosolventpolarityandrecognitionabilitytOmetalionswerestudiedthroughtheUVandFLspectraTwelveofsingle。。anddouble‘a(chǎn)rmedprob

3、esweredesignedbyintroducingvariousreceptorscontainingN，OandSmomstothecomarinsThefluorescentprobewithsinglearmedreceptor3N(2hydroxyethyl)carboxamido7(diethylamin01coumarin(E1)showsremarkablysensitivityandselectivityrespon

4、setoFe3whichwasturnedoutasanICTmechanismInotherswithdoublearmedreceptorstheprobes4一州，Nbisacetoxyethylaminomethyl)7一methoxycoumarin(B3)and4【(N，Nbis(diethylaminodithiocarboxyethylaminomethyl)7methoxycoumarin(B4)withpronoun

5、cedfluorescenceenhancementresponsetospecialheavyandtransitionmetalionswereproposedasPETmechanism；forthosewithdoublearmedreceptorsfollowingICTmechanism，theirperformancesareinfluencedbynotonlythestructureofthereceptorsbuta

6、lsotheattachingpositionofitThirteenfluorescentprobeswithtwincoumarinfluorophoresweredesignedWhen6，10dimethyl2，6，10，14一tetraazapentadecanewasintroducedasspacerandreceptorTheprobe2，6，10。14一tetramethyl一1，15一bis(7methoxy4cou

7、marinyl)2，6，10，14一tetraazapentadecane(G4)basedonPETmechanismwasfoundtoenhancethefluorescenceintensityto100times，whichcanbeusedasfluorescentswitchesforprotonsThisprobecanalsecognizeHg。2andFe3sensitivelyinaqueoussolutionTh

8、ecolorimetricsensorsusedtothedetectionofFe3areveryscarceInthisthesissensorsNNbis(7_diethylamino3一coumarinformyl)m—phenylenebis(methylamine)(H3)，N，Nbis(7一diethylamino一3coumarinformyl)hexanediamine(H4)werefoundtoshowexcell

9、entselectivitytowardsFe3Twosensors19bis(4methoxy7coumarinoxy)一3，7一dithianonane(11)，18bis(4一methoxy7一coumarinoxy)3，6dithiaoctane(12)forrecognitionofH92werealsoobtainedbyintroducing1，3bis(methylthio)propandiyland12bis(meth