樹突狀細胞聯(lián)合化療治療胃腸道腫瘤前后IFN-γ、IL-10、IL-12的比較研究和臨床研究.pdf

1、青島大學碩士學位論文樹突狀細胞聯(lián)合化療治療胃腸道腫瘤前后IFNγ、IL10、IL12的比較研究和臨床研究姓名：趙清葉申請學位級別：碩士專業(yè)：腫瘤學指導教師：馬學真20070526英文摘要Experimentalstudyof[FN—Y，IL一10IL一12andclinicalstudyofdendriticcellcombinedwithchemotherapyforgastrointestinalCanCerAbstractobje

2、ctive：toestablishthespecificimmunologicalindexesofsensitizeddendriticcellbyobservingthechangeofIFNy、IL一10、IL12intheperiphealbloodingastrointestinalcancerbeforeandafterdendriticcellcombinedwithchemotherapyandobservethecli

3、nicalcurativeeffectandsideeffectofthecombinedchemotherapyingastrointestinalcanceEMethods：fortypatientswithadvancedgastriccancerorcolorectalcancerwerermadomlydividedintochemotherapygroup(controlgoup)anddendriticcellcombin

4、edwithchemotherapygroup(observinggroup)，sensitizedmaturedDCswerederivedfromperiphealbloodmonocytesofthepatientsinobservinggroupbeforechemotherapywhichwereloadedtumorlysateandcultivatedinvitro，inthecourseofcultivation，the

5、patientsinobservinggroupreceivedoxaliplatin(L—OHP)plus5FU／CFsensitizedmaturedDCswereadministeredafterchemotherapythepatientsincontrolgroupreceivedthetreatmentofthesanleregimentheconcentrationsofIFNY，IL一10，IL一12inbloodser

6、umweredetectedbeforeandaftertreatment；toxicityclinicalbenefitresponserateandKPSwereobsevedResults：theconcentrationsoflFNY，IL12，IL一10inbloodSerumandKPSwerenotsignificantdifferenceintwogroupsbeforetreatmentInobservinggroup

7、，theconcentrationsoflFN—Y，IL一12inbloodserLiInandKPSweresignificantlyincreased，andtheconcentrationoflL10wasdecreasedaftetreatment，incontolgroup，theconcentrationsoflFN—Y，IL—12inbloodserumandKPSweredecreased，andtheconcentra