連環(huán)蛋白p120在人胰腺癌組織中的表達(dá)及其意義.pdf

1、東南大學(xué)碩士學(xué)位論文連環(huán)蛋白p120在人胰腺癌組織中的表達(dá)及其意義姓名：桂德春申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：臨床醫(yī)學(xué)；外科學(xué)指導(dǎo)教師：周家華20110603英文摘要AbstractExpressionandsignificanceofpl20—catenininpancreaticCarClnOmaMedicalCollegeofSoutlleastUniVers時(shí)objectiveT0ex鋤眥也eeXpressioninViVo鋤dcell

2、ular10calizationofp120—catenin(pl20ctn)觚dE—cadherininp鋤creaticcarcinoma，inVestigatetlle嬲sociationofp120ctnexpression塒tlltlleclillicopatllologicfeatures鋤dprognosisofpancreaticcarcinom如觚dexplorcmerole鋤dmechaIlismofpl20ctni

3、nⅡ1edeVelopmentofp鋤creaticcarcinomMethodsImmunohistochemist巧waSperf0肌edt0inveStigate也eexpressionofpl20c協(xié)，EcadherinproteinarldCD34inpancreaticcarcinomatissues鯽ditSadjacenttissuesof53patientS、析tllpallcreaticcafcirlomaThere

4、lationsKpbe鉚eentheexpressionofp120ctIl鋤dpamologicalcharacteriSticswaSalso弱sessedResuItsComparied、)l，itllmea內(nèi)acenttissues，morereducedorlossofmembmousexpression卸dcyt叩lasmiclocalizationofp120c恤、Ⅳ硒found證paIlcreaticcarcinomat

5、issues(34／53，641％，p005)E—cadhe血proteinexpression(30／53，566％)w嬲similartotllatofpl20ct瑪additionally’tIlerewaSapositiVerelationsllipbet、veenp120ctnproteinandEcadherinproteinexpression(尸005)inpancreaticcarcinomatissuesSiIlli

6、la訂y，apositi、吧con℃lationcanbealsofourldbetweentllealteredexpressionofpl20ctnarldMVDValueAbno咖alexpressionofpl20c恤iIlp鋤creaticcarciIlomatissuesw嬲notonlycorrelated撕thtumordi仃erentiation，l舯phnodem蝴is，pn蹦stage(尸005)，butalsow

7、imapoorpro印osis妒005)ConclusionsThepl20ctIlexpressionisalteredaIldrcl鋤edtonotomymeexprcssionofE—c礎(chǔ)lerin鋤dCD34proteiIl，butalsotIunordi能rentiation，lymphnodemet粕is，p7INMstageandprognosisofpancreaticcarcinomanindicatestIlatpl