子宮頸癌中Ezrin的表達(dá)及其臨床意義.pdf

1、Background: The most damaging change during cancer progression is theswitch from a locally growing tumor to a metastatic killer. Tumor progression andmetastasis are common phenomena in cancer. There are many factors rela

2、ted to thisswitch and is believed to involve numerous alterations that allow tumor cells tocomplete the complex series of events including invasion of the surrounding stroma,angiogenesis, transport of nutrients and provi

3、sion of routes to enter the circulatorysystem then metastasize distant sites. During the process of invasion there are several"molecules" that may assist cancer cells to locate the favorable organ to metastasize,to inter

4、act with endothelial cells, to migrate through the endothelium and subsequentlypenetrate structures including matrix and vascular endothelium. Recent studies showed that the membrane-linking protein Ezrin is the most

5、important member of the ERM(Ezrin/radixin/moesin). It regulates the determinationand maintenance of cell shape, cell adhesion to the extracellular matrix, cell--cellinteraction, receptor tyrosine-kinase signaling, signal

6、 transduction pathway andinteractions with the Akt-mediated cellular apoptotic machinery. Ezrin plays animportant role in cell motility, cell polarity, citokinesis, phagocytosis, and stabilization ofintercellular junctio

7、ns; participates in membrane trafficking pathways, and integrationof membrane transport with signaling pathways. Ezrin is highly expressed in severaltypes of human cancers and correlated between its expression and histop

8、athologicaldata as well as patient outcome, which have been shown in巾abdomyosarcoma,osteosarcoma, brain hemangioblastoma, uterine endometroid adenocarcinoma, uvealmalignant melanoma, renal adenocarcinoma, human pancreati

9、c adenocarcinoma,prostate cancer, serous ovarian carcinoma and breast cancer. Cervical cancer is the second most common cancer in women worldwide, andbecomes the most prevalent female malignancy and the leading cause

10、 of death bycancer in developing countries. However, studies of the expression of Ezrin have notyet been reported on human cervical cancer. This study assesses a group of samplesof cervical cancer in order to evaluate Ez

11、rin expression and its relation withhistopathological data. The expression of Ezdn in cervical intraepithelial neoplasia(CIN) acrd normal tissue was also studied as controls. Conclusions:1. There are gradual increase

12、d expressions of Ezrin from normal throughout CIN to cancer of the cervix, indicating that over-expression of Ezrin plays a role in carcinogenesis of the cervix.2. The expression of Ezrin is higher in outer one-third s