北京大學生命科學學院上目錄導師簡介（46人）

1、<p>　　北京大學生命科學學院上目錄導師簡介（46人）</p><p>　　安成才, 教授，博士生導師3</p><p>　　白書農(nóng), 教授，博士生導師4</p><p>　　蔡 宏, 教授，博士生導師5</p><p>　　柴 真, 教授，博士生導師6</p><p>　　昌增益, 教授，博士生導

2、師7</p><p>　　陳建國, 教授，博士生導師10</p><p>　　鄧宏魁, 教授，博士生導師12</p><p>　　鄧興旺, 教授，博士生導師13</p><p>　　顧紅雅, 教授，博士生導師14</p><p>　　顧 軍, 教授，博士生導師15</p><p>　

3、　郭紅衛(wèi), 教授，博士生導師17</p><p>　　紀建國, 教授，博士生導師18</p><p>　　蔣爭凡, 研究員，博士生導師19</p><p>　　金長文, 教授，博士生導師20</p><p>　　孔道春, 教授，博士生導師22</p><p>　　李 毅, 教授，博士生導師23</p&

4、gt;<p>　　林 碩, 教授，博士生導師(Cheung Kong Visiting Scholar)24</p><p>　　劉 東, 研究員，博士生導師25</p><p>　　劉 磊, 研究員，博士生導師27</p><p>　　龍漫遠, 教授，博士生導師28</p><p>　　羅述金, 研究員，博士生導師3

5、0</p><p>　　呂 植, 教授，博士生導師31</p><p>　　秦詠梅, 教授，博士生導師32</p><p>　　瞿禮嘉, 教授，博士生導師34</p><p>　　饒廣遠, 教授，博士生導師35</p><p>　　饒 毅, 講席教授，博士生導師36</p><p>　

6、　蘇都莫日根, 教授，博士生導師38</p><p>　　蘇曉東, 教授，博士生導師39</p><p>　　陶樂天, 研究員，博士生導師40</p><p>　　王世強, 教授，博士生導師40</p><p>　　王憶平, 教授，博士生導師42</p><p>　　魏麗萍, 教授，博士生導師43</

7、p><p>　　魏文勝, 研究員，博士生導師44</p><p>　　夏 斌, 教授，博士生導師45</p><p>　　謝燦, 研究員，博士生導師45</p><p>　　許智宏, 院士，教授，博士生導師47</p><p>　　翟中和, 院士，教授，博士生導師48</p><p>　　

8、張 博, 教授，博士生導師49</p><p>　　張傳茂, 教授，博士生導師51</p><p>　　鄭曉峰, 教授，博士生導師52</p><p>　　朱玉賢, 教授，博士生導師55</p><p>　　朱作言, 院士，教授，博士生導師56</p><p>　　范六民, 教授，博士生導師57</p

9、><p>　　滕俊琳, 副教授，博士生導師59</p><p>　　王戎疆, 副教授，博士生導師60</p><p>　　張 研, 副教授，博士生導師61</p><p>　　安成才, 教授，博士生導師</p><p>　　Email: chcaian@pku.edu.cn</p><p>　

10、　TEL： 86 - 10 - 6275-2405 </p><p>　　Fax：86 - 10 - 6275-9070 </p><p><b>　　科研領(lǐng)域描述</b></p><p>　　植物代謝調(diào)控及生物藥物：（1）植物代謝調(diào)控的分子機理；（2）生物藥物基因工程。</p><p><b>　　主要研究興

11、趣：</b></p><p>　　植物抗病防衛(wèi)反應(yīng)的調(diào)控機理：植物對病原物信號的傳遞及其抗病防衛(wèi)反應(yīng)的激發(fā)與解除激活的分子機理 </p><p>　　天花粉蛋白導向藥物ScFv-TCS及其癌細胞定向識別與選擇性殺傷機制 </p><p>　　油料植物脂肪酸合成代謝的分子機理及其高產(chǎn)油料作物的分子育種技術(shù)研究 </p><p>　　

12、控藻生物的遺傳工程改良及其在富營養(yǎng)化水體修復中的應(yīng)用技術(shù)研究  </p><p><b>　　代表性論文</b></p><p>　　Li Xu, Ye Wang, Lijiang Wang, Yin Gao, Chengcai An* , TYchi, a novel chitinase with RNA N-glycosidase and anti-tu

13、mor activities , Frontiers in Bioscience , 2008 , 13: 3127-3135 </p><p>　　Liu Xinyao, Kong Shuanglei, Shi Miao, Fu Liwen, Gao Yin and An Chengcai* , Genomic Analysis of Freshwater Cyanophage Pf-WMP3 Infectin

14、g Cyanobacterium Phormidium foveolarum: The Conserved Elements for a Phage , Microbial Ecology , 2008 , 56:671-680 </p><p>　　Li Xu, Lijiang Wang, Tao Liu, Wanqiang Qian, Yin Gao, Chengcai An , Triton, a nove

15、l family of miniature inverted-repeat transposable elements (MITEs) in Trichosanthes kirilowii Maximowicz and its effect on gene regulation , BBRC , 2007 , 364: 668-674 </p><p>　　Tao Liu, Jia-yu Gu, Chen-jia

16、 Xu, Yin Gao, Cheng-cai An* , Overproduction of OsSLRL2 alters the development of transgenic Arabidopsis plants , BBRC , 2007 , 358: 983–989 </p><p>　　Wanqiang Qian, Guihong Tan, Shanping He, Xinyue Zhang, X

17、u Zhang, Yin Gao, Hongxia Liu and Chengcai An* , Identification of a new AT-rich-element binding factor PsATF1 and its combined effect with PsGBF on the activation of PsCHS1 promoter , Frontiers in Bioscience , 2007 , Vo

18、l. 12: 1670-1679 </p><p>　　Xinyao Liu, Miao Shi, Shuanglei Kong, Yin Gao, Chengcai An* , Cyanophage Pf-WMP4, a T7-like phage infecting the freshwater cyanobacterium Phormidium foveolarum: Complete genomesequ

19、ence and DNA translocation , Virology , 2007 , 366: 28–39 </p><p>　　Xin-Yue Zhang, Ye Wu, Jin-Yuan Yan, Yin Gao, Ye Wang, Shuang-Li Mi, Cheng-Cai An* , Y55 and D78 are crucial amino acid residues of a new Ig

20、E epitope on trichosanthin , BBRC , 2006 , 343(4):1251-1256 </p><p>　　Liu Xinyao, Shi Miao, Liao Yonghong, Gao Yin, Zhang Zhongkai, Wen Donghui, Wu Weizhong and An Chengcai* , Isolation of an amoebae capable

21、 of grazing Anabaena flos-aquae from Dianchi Lake and its identification by SSU rRNA gene , Microbial Ecology , 2006 , Vol. 51: 315-325 </p><p>　　Shuang-li Mi, Cheng-cai An*, Ye Wang, Ji-yuan Chen, Nan-ying

22、Che, Yin Gao and Zhang-liang Chen , Trichomislin, a novel ribosome-inactivating protein, induces apoptosis that involves mitochondria and caspase-3 , Archives of Biochemistry and Biophysics , 2005 , 434(2): 258-265 </

23、p><p>　　Guihong Tan, Yin Gao, Miao Shi, Xinyue Zhang, Shanping He, Zhangliang Chen and Chengcai An* , SiteFinding-PCR: a simple and efficient PCR method for chromosome walking , Nucleic Acids Research , 2005 ,

24、Vol. 33, No. 13 e122 </p><p>　　Yan Yuanxin, An Chengcai*, Li Li, Gu Jiayu, Tan Guihong and Chen Zhangliang , T-linker Specific Ligation PCR (T-linker-PCR): An advanced PCR technique for chromosome walking or

25、 for isolation of tagged DNA ends , Nucleic Acids Research , 2003 , Vol. 31(12): 1-7 e68 </p><p>　　Chunyang Zhang, Chengcai An*, Rongying Wang, Yixuan Gong, Hui Ma, Dieyan Chen & Zhangliang Chen , Capill

26、ary Electrophoresis and Circular Dichroism Study of Trichosanthin and Its Mutants , Talanta , 2002 , 57: 467-473 </p><p>　　==============================================</p><p>　　白書農(nóng), 教授，博士生導師&l

27、t;/p><p>　　TEL： 86 - 10 - 6275-1444 </p><p>　　Fax：86 - 10 - 6275-1526 </p><p><b>　　科研領(lǐng)域描述</b></p><p>　　本實驗室主要興趣在于： </p><p>　　1 以雄蕊為對象的植物器官形成調(diào)控機制

28、2 植物發(fā)育事件相關(guān)基因表達在染色質(zhì)水平調(diào)控     植物器官形成主要指來自頂端分生組織的一團未分化細胞如何形成具有特定形態(tài)與功能的三維結(jié)構(gòu)，是植物發(fā)育中的一個重要過程。我們利用雄蕊為對象，從分析導致黃瓜雌花雄蕊發(fā)育停滯的分子機制、和發(fā)育早期不同階段的水稻雄蕊基于表達譜兩個角度入手，嘗試解析雄蕊早期發(fā)育這一復雜的多細胞結(jié)構(gòu)形態(tài)建成過程中關(guān)鍵的發(fā)育事件及其在分子水平的調(diào)控機制。這將不僅幫助我們了解雄蕊形成的

29、機制，還可以幫助我們了解多細胞結(jié)構(gòu)形態(tài)建成過程中的一些基本規(guī)律。</p><p>　　在我們前期的工作中，發(fā)現(xiàn)基因表達的染色質(zhì)水平調(diào)控在植物發(fā)育事件中具有重要的作用。因此，我們面前利用擬南芥根表皮細胞分化過程中模式形成這一發(fā)育事件，探討發(fā)育相關(guān)基因表達在染色質(zhì)水平的調(diào)控機制，并希望利用在此研究中所積累的經(jīng)驗，幫助我們理解雄蕊早期發(fā)育的調(diào)控機制。 </p><p><b>

30、;　　代表性論文</b></p><p>　　Duan, QH et al. , Stamen development in Arabidopsis is arrested by organ-specific overexpression of a cucumber ethylene synthesis gene CsACO2 , Planta , 2008 , 228 (4): 537-543 &l

31、t;/p><p>　　Lu, XC et al. , Photoperiodic responses of various morphogenetic events after panicle initiation in late japonica rice (Oryza sativa L. vs. japonica). , Plant Biology , 2008 , 10: 388-397 </p>

32、<p>　　Lu and Gong et al. , Molecular analysis of early rice stamen development using organ-specific gene expression profiling , Plant Mol. Biol. , 2006 , 61: 845-861 </p><p>　　Xu CR et al. , Histone ac

33、etylation affects expression of cellular patterning genes in the Arabidopsis root epidermis , PNAS , 2005 , 102: 14469-14474 </p><p>　　Bai SL et al. , Developmental analyses reveal early arrests of the spore

34、-bearing parts of reproductive organs in unisexual flowers of cucumber (Cucumis sativus L.). , Planta , 2004 , 220 (2): 230-240 </p><p>　　Hao YJ Wang DH et al. , DNA damage in early primordial anther is clos

35、ely correlated with the stamen arrest in female flower of cucumber (Cucumis sativus L.) , Planta , 2003 , 217(6): 888-95 </p><p>　　====================================================</p><p>　　蔡

36、 宏, 教授，博士生導師</p><p>　　Email: hcai@pku.edu.cn</p><p>　　Fax：86 - 10 - 6275-4427 </p><p>　　TEL： 86 - 10 - 6275-6077 </p><p><b>　　科研領(lǐng)域描述</b></p><p>

37、;　　本實驗室主要興趣在于：</p><p>　　多價DNA疫苗的分子機理。 </p><p>　　基因治療的機制研究。 </p><p>　　植物反應(yīng)器的研究。   </p><p>　　結(jié)核病是一種人畜共患病，嚴重威脅著人類的健康。傳統(tǒng)的BCG疫苗的保護效率不一致。DNA疫苗可誘導體液和細胞免疫應(yīng)答，而結(jié)核桿菌和布氏桿

38、菌都是胞內(nèi)寄生菌，DNA疫苗是未來非常具有開發(fā)前景的新型疫苗。實驗室通過動物實驗篩選優(yōu)良的免疫主導性抗原，并通過DNA免疫的手段測定其保護效率及在動物保護中的作用機制。目前為止，建立了一套可靠的核酸疫苗免疫、檢測評價體系，比較了各種多價不同組合及其分別與不同佐劑?；虬鼊┗旌厦庖叩谋Ｗo效力，探討了多種提高疫苗效力和持續(xù)期的策略和可行方法，并研究了各種方法在激發(fā)機體免疫機制上的差異和途徑。</p><p>　　除了

39、探討DNA疫苗在預防方面的作用，我們通過DNA疫苗結(jié)合傳統(tǒng)化學藥物的方法對受感染的小鼠及牛進行基因治療，進而探討在感染后，DNA疫苗對機體內(nèi)免疫反應(yīng)類型的改變狀況。</p><p>　　為進一步推進疫苗的實用性，我們構(gòu)建了馬鈴薯來源的植物疫苗，動物可口服該疫苗而無須打針。通過動物實驗，植物疫苗在小鼠體內(nèi)誘導了體液免疫（尤其是粘膜免疫應(yīng)答）和細胞應(yīng)答反應(yīng)。</p><p><b>

40、　　代表性論文</b></p><p>　　Hu Xi-Dan, Chen Su-Ting, Yu Da-Hai, Li Shu-Xia, Cai Hong , Immunotherapy with combined DNA vaccines is an effective treatment for M. bovis infection in cattle. , VACCINE , 2009 , 2

41、7:1317-1322 </p><p>　　Hu Xi-Dan, Yu Da-Hai, Chen Su-Ting, Li Shu-Xia, Cai Hong , A Combined DNA Vaccine Provides Protective Immunity Against Mycobacterium bovis and Brucella abortus in Cattle. , DNA AND CELL

42、 BIOLOGY , 2009 , 28(4):191-199 </p><p>　　Li Min, Yu Da-Hai,Cai Hong , The Synthetic Antimicrobial Peptide KLKL5KLK Enhances the Protection and Efficacy of the Combined DNA Vaccine against Mycobacterium tube

43、rculosis. , DNA AND CELL BIOLOGY , 2008 , 27(8):405-413 </p><p>　　Yu Da-Hai,Hu Xi-Dan,Cai Hong , Efficient tuberculosis treatment in mice using chemotherapy and immunotherapy with the combined DNA vaccine en

44、coding Ag85B, MPT-64 and MPT-83. , GENE THERAPY , 2008 , 15:652–659 </p><p>　　Yu Da-Hai, Li Min, Hu Xi-Dan, Cai Hong , A Combined DNA Vaccine Enhances Protective Immunity against Mycobacterium tuberculosis a

45、nd Brucella abortus in the Presence of an IL-12 Expression Vector. , VACCINE , 2007 , 25(9):6744-6754 </p><p>　　Yu Da-Hai, Cai Hong**, Hu Xi-Dan, Li Min , A Combined DNA Vaccine Encoding BCSP31, SOD and L7/L

46、12 Confers High Protection against Brucella abortus 2308 by Inducing Specific CTL Responses. , DNA AND CELL BIOLOGY , 2007 , 26 (6): 435-443 </p><p>　　Cai Hong*, Yu Da-Hai, Hu Xi-Dan, Li Shu-Xia, and Zhu Yu-

47、Xian. , A Combined DNA Vaccine-Prime, BCG-Boost Strategy Results in Better Protection against Mycobacterium. bovis Challenge. , DNA AND CELL BIOLOGY , 2006 , 25 (8): 438-447 </p><p>　　Cai Hong**, Yu Da-Hai,

48、Tian Xia, Zhu Yu-Xian. , Co-administration of interleukin 2 plasmid DNA with combined DNA vaccines enhance significantly the protective efficacy against Mycobacterium Tuberculosis. , DNA AND CELL BIOLOGY , 2005 , 24 (10)

49、: 605-613 </p><p>　　Cai Hong**, Hu Xidan, Yu Da-Hai, Li Shu-Xia, Zhu Yu-Xian. , Combined DNA vaccine encapsulated in microspheres enhanced protection efficacy against Mycobacterium tuberculosis infection of

50、mice. , VACCINE , 2005 , 23 (32): 4167-4174 </p><p>　　Cai Hong**, Tian Xia, Hu Xidan, Li Shu-Xia, Yu Da-Hai, Zhu Yu-Xian. , Combined DNA vaccines formulated either in DDA or in saline protect cattle from Myc

51、obacterium bovis infection. , VACCINE , 2005 , 23 (30): 3887-3895 </p><p>　　Cai Hong, Tian Xia, Hu Xi-Dan, Zhuang Yu-Hui, Zhu Yu-Xian* , Combined DNA Vaccines Formulated in DDA Enhance Protective Immunity ag

52、ainst Tuberculosis. , DNA AND CELL BIOLOGY , 2004 , 23 (7): 450-456 </p><p>　　=================================================</p><p>　　柴 真, 教授，博士生導師</p><p>　　Fax：86 - 10 - 6275-15

53、26 </p><p>　　TEL： 86 - 10 - 6275-7830 </p><p><b>　　科研領(lǐng)域描述</b></p><p>　　本實驗室主要興趣在于： </p><p>　　腦損傷和修復過程中神經(jīng)元鈣穩(wěn)態(tài)的調(diào)控機制。 </p><p>　　神經(jīng)元和膠質(zhì)細胞低氧損傷或適應(yīng)的細胞

54、機制。 </p><p>　　細胞因子及其信號轉(zhuǎn)導途徑在體溫調(diào)節(jié)中的作用。  </p><p><b>　　代表性論文</b></p><p>　　Tang AH, Chai Z and Wang SQ* , Dark rearing alters the short-term synaptic plasticity in visua

55、l cortex. , Neurosci Lett , 2007 , 206: 799-806 </p><p>　　Zhou C, Ye HH, Wang SQ, Chai Z* , Interleukin-1β regulation of N-type Ca2+ channels in cortical neurons. , Neurosci Lett , 2006 , 403: 181-185. </

56、p><p>　　Zhou C, Tai C, Ye HH, Ren X, Chen JG, Wang, SQ, Chai Z* , Interleukin-1β downregulates the L-Type Ca2+ channel activity by depressing the expression of channel protein in cortical neurons. , J Cell Phys

57、iol , 2006 , 206: 799-806. </p><p>　　Wang TF, Zhou C, Tang AH, Wang SQ, Chai Z* , Cellular mechanism for spontaneous calcium oscillations in astrocytes. , Acta Pharmacol Sinica , 2006 , 27: 861-868 </p>

58、;<p>　　Fu Y, Zhang GQ, Hao XM, Wu CH, Chai Z, Wang SQ* , Temperature dependence and thermodynamic properties of Ca sparks in rat cardiomyocytes. , Biophys J , 2005 , 89: 2533-2541. </p><p>　　Alheim K,

59、 Chai Z, Fantuzzi G, Hasanvan H, Di Santo E, Ghezzi P, Dinarello CA, Bartfai T* , Hyperresponsive febrile reactions to IL-1β in IL-1β deficient mice; comparison with cytokine mRNA and protein levels. , Proc Natl Acad Sci

60、 USA , 1997 , 94: 2681-2686. </p><p>　　Chai Z, Gatti S, Toniatti C, Poli V, Bartfai T* , Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide

61、 or IL-1β: a study on IL-6-deficient mice. , J Exp Med , 1996 , 183: 311-316 </p><p>　　Loudkvist J, Chai Z, Teheranian R, Hasanvan H, Bartfai T, Jenck F, Widmer U, Moreau JL , A non peptidic corticotropin re

62、leasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity. , Eur J Pharmacol , 1996 , 309: 195-200. </p><p>　　Chai Z, Alheim K, Lundkvist J, Gatti S, Bartfai T* , Subchromic g

63、lucocorticoid pretreatment reversibly attenuates IL-1β induced fever in rats; IL-6 mRNA is elevated while IL-1α and IL-1β mRNAs are suppressed, in the CNS. , Cytokine , 1996 , 8: 227-237. </p><p>　　Malinowsk

64、y D, Chai Z, Bristulf J, Simoncsits A, Bartfai T* , The type I interleukin-1 receptor mediates fever in rat as shown by interleukin-1 receptor subtype selective ligands. , Neurosci lett , 1995 , 201: 33-36. </p>&

65、lt;p>　　==============================================</p><p>　　昌增益, 教授，博士生導師</p><p>　　生命科學學院副院長, 北京大學跨院系蛋白質(zhì)科學中心 主任 </p><p>　　Email: changzy@pku.edu.cn</p><p>　　Fax：8

66、6 - 10 - 62751526 </p><p>　　TEL： 86 - 10 - 62758822 </p><p><b>　　科研領(lǐng)域描述</b></p><p>　　本實驗室主要興趣在于：1. 生物的脅迫響應(yīng),包括衰老和休眠現(xiàn)象的分子機制 (Stress responses of living organisms:

67、60;including the molecular mechanism of aging and dormancy) 2. 生物體內(nèi)蛋白質(zhì)-蛋白質(zhì)相互作用的發(fā)生情況、機制、及生物學意義 (Mechanism and biological significance of protein-protein interactions)</p><p>　　任何生命形式都不可避免地要經(jīng)歷像

68、高溫、極端pH值、活性氧等有毒物質(zhì)的存在等脅迫條件。在這樣的條件下，生物體內(nèi)的大分子，如DNA、RNA、蛋白質(zhì)等由非共價弱相互作用維持的空間結(jié)構(gòu)都將受到影響。這其中可能以蛋白質(zhì)分子受到的威脅最大，蛋白質(zhì)分子的去折疊往往會導致聚集的發(fā)生，而這將意味著蛋白質(zhì)分子功能的喪失。過去的研究表明，各種生物的基因組都編碼了一類被稱為分子伴侶（或熱休克蛋白、或脅迫蛋白等）的蛋白質(zhì)分子。這些蛋白質(zhì)的角色就是保護生物體內(nèi)那些容易發(fā)生去折疊和聚集的蛋白質(zhì)。這

69、些“保鏢”蛋白質(zhì)，參與了對體內(nèi)其它蛋白質(zhì)分子的“生、老、病、死”等過程。我們關(guān)注的一些問題包括：脅迫蛋白質(zhì)是如何在生物體內(nèi)發(fā)揮其功能的？脅迫蛋白質(zhì)分子的結(jié)構(gòu)如何對脅迫條件發(fā)生瞬時響應(yīng)而導致生物學活性順時性提高的？部分生命個體以休眠方式應(yīng)對極端脅迫條件的分子機制是什么？與此相關(guān)的衰老現(xiàn)象和休眠現(xiàn)象的分子機制是什么？等等。</p><p>　　蛋白質(zhì)在生物體內(nèi)發(fā)揮作用是通過與其它分子發(fā)生相互作用而完成的。大量的蛋白質(zhì)

70、分子自身或相互之間也發(fā)生著大量的相互作用。自身的相互作用，形成同源寡聚體，不同蛋白質(zhì)分子之間的相互作用即形成異源寡聚體。盡管過去的體外或體內(nèi)研究已經(jīng)揭示了大量特異的蛋白質(zhì)之間的相互作用，但大量發(fā)生于生物體內(nèi)的動態(tài)的或弱的相互作用目前還難以鑒定和深入研究。我們關(guān)注的一些問題包括：很多通過體外研究被鑒定為以單亞基形式存在的蛋白質(zhì)，在體內(nèi)是否能夠形成同源寡聚體？能夠在活細胞條件下鑒定出與特異蛋白質(zhì)發(fā)生相互作用的蛋白質(zhì)？這樣的以同源或異源寡聚形

71、式發(fā)生的蛋白質(zhì)-蛋白質(zhì)相互作用如何完成特定的生物學功能？等等。</p><p><b>　　代表性論文</b></p><p>　　Zengyi Chang , The CUSBEA Program: Twenty Years Later , IUBMB Life , 2009 , 61:(6)555-565 (feature article) </p>

72、<p>　　Zengyi Chang , Posttranslational modulation of Biological Activities of Molecular Chaperones , Science in China Series C: Life Sciences , 2009 , 52(6):515-520. , Invited Critical Review , [Full Text] </p&g

73、t;<p>　　Yunbiao Wang, Anastasia N. Ezemaduka, Yan Tang and Zengyi Chang , Understanding the Mechanism of the Dormant Dauer Formation of C. elegans: From Genetics to Biochemistry , IUBMB Life , 2009 , 61(6):607-612

74、. , invited critical review </p><p>　　FENG Yongjun, ZHANG Meng, HU Mingxi, ZHENG Jie, JIAO Wangwang & CHANG Zengyi , Disassembly Intermediates of RbsD Protein remain Oligomeric despite the loss of an int

75、act secondary structure , Sci. China Ser. C-Life Sciences , 2009 , in press </p><p>　　Jiang, J.S., Zhang, X. F., Chen, Y., Wu, Y., Zhou, Z. H., Chang, Z., Sui, S.F. , Activation of DegP Chaperone-Protease vi

76、a Formation of Large Cage-like Oligomers upon Binding to Substrate Proteins , Proc. Natl. Acad. Sci. USA , 2008 , 105(33):11939-11944. , 通訊作者(corresponding author) </p><p>　　Jiao, W., Hong, W., Li, P., Sun,

77、S., Ma, J., Qian, M., Hu, M., and Chang, Z. , The Dramatically Increased Chaperone Activity of Small Heat Shock Protein IbpB is Retained for an Extended Period of Time after the Stress Condition is Removed , Biochem. J.

78、, 2008 , 15;410(1):63-70. , [Abstract] </p><p>　　Liu, C., Mao, K., Zhang, M., Sun, Z., Hong, W., Li, C., Peng, B., and Chang, Z. , The SH3-Like Domain Switches Its Interaction Partners to Modulate the Repres

79、sion Activity of Mycobacterial Iron-Dependent Transcription Regulator (IdeR) in Response to Metal Ion Fluctuations , J. Biol. Chem. , 2008 , Vol. 283, Issue 4, 2439-2453 , [Abstract] , [Full Text] </p><p>　　

80、Wu, Y., Hong, W., Zhang, L., and Chang, Z. , Conserved Amphiphilic Feature Is Essential for Periplasmic Chaperone HdeA to Support Acid Resistance in Enteric Bacteria , Biochem. J. , 2008 , 412:389-397. , [Abstract] </

81、p><p>　　馬靜， 葛熙、昌增益 , 蛋白質(zhì)功能研究：歷史、現(xiàn)狀和將來 , 生命科學 , 2007 , 19（3）：294-300 , 應(yīng)邀綜述 </p><p>　　Feng, Y., Jiao, W., Fu, X., and Chang, Z. , Stepwise Disassembly and Apparent Non-stepwise Reassembly for the Ol

82、igomeric RbsD Protein , Protein Science , 2006 , 15(6):1441-1448. </p><p>　　Fu, X., and Chang, Z , Identification of bis-ANS binding sites in Mycobacterium tuberculosis small heat shock protein Hsp16.3: Evid

83、ences for a two-step substrate-binding mechanism , Biochem. Biophys. Res. Commun. , 2006 , 349:169-171. </p><p>　　Hong, W., Jiao, W., Hu, J., Zhang, J., Liu, C., Fu, X., Shen, D., Xia, B., and Chang, Z. , Pe

84、riplasmic protein HdeA exhibits chaperone-like activity exclusively within stomach pH range by transforming into disordered conformation , J Biol Chem. , 2005 , Vol. 280, Issue 29, 27029-27034 , [Abstract] , [Full Text]

85、</p><p>　　Jiao，W., Qian, M., Li, P., Zhao, L., and Chang, Z. , The essential role of the flexible termini in the temperature-responsiveness of the oligomeric state and chaperone-like activity for the polydis

86、perse small heat shock protein IbpB from Escherichia coli , J Mol Biol. , 2005 , Volume 347, Issue 4, 8 April 2005, Pages 871-884 , [Full Text] </p><p>　　Fu, X., Zhang, H., Zhang, X., Cao, Y., Jiao, W., Liu,

87、 C., Song, Y., Abulimiti, A., and Chang, Z. , A dual role for the N-terminal region of Mycobacterium tuberculosis Hsp16.3 in self-oligomerization and binding denaturing substrate proteins , J Biol Chem. , 2005 , Vol. 280

88、, Issue 8, 6337-6348 , [Abstract] , [Full Text] </p><p>　　Zhang, H. Fu, X. Jiao, W., Zhang, X., Liu, C., and Chang, Z. , The association of small heat shock protein Hsp16.3 with the plasma membrane of Mycoba

89、cterium tuberculosis: dissociation of oligomers is a prerequisite , Biochem Biophys Res Commun., , 2005 , 330:1055-1061. </p><p>　　Jiao, W., Li, P., Zhang, J., Zhang, H., Chang, Z. , Small Heat Shock Protein

90、s Function in the Insoluble Protein Complex , Biochem Biophys Res Commun., , 2005 , 335(1):227-231. </p><p>　　Fu, X. and Chang ,Z. , Phylogenetic and biochemical studies reveal a potential evolutionary origi

91、n of animal small heat shock proteins from bacterial class A , J. Mol. Evol., , 2005 , 62:257-266. </p><p>　　Zhang, X.,Fu, X., Zhang, H., Liu, C. Jiao, W., and Chang, Z. , Chaperone-like Activity of β-Casein

92、 , Interna. J. Biochem. Cell Biol., , 2005 , 37:1232-1240. </p><p>　　Fu, X., Zhang, X., and Chang, Z. , 4'-dianilino-1,1'-binaphthyl-5,5'-sulfonate (bis-ANS), a novel molecule having chaperone-li

93、ke activity , Biochem Biophys Res Commun., , 2005 , 329:1087-1093. </p><p>　　Liu Y., Fu, X., Shen, J., Zhang, H., Hong, W., and Chang, Z. , Periplasmic proteins of Escherichia coli are highly resistant to ag

94、gregation: reappraisal for roles of molecular chaperones in periplasm , Biochem Biophys Res Commun. , 2004 , Volume 316, Issue 3, 9 April 2004 , [Full Text] </p><p>　　昌增益，焦旺旺 , 細胞內(nèi)一種耗能蛋白質(zhì)降解途徑的發(fā)現(xiàn)：2004年諾貝爾化學獎工

95、作介紹 , 生物物理學報 , 2004 , 第20卷第6期,第421－425頁。 , 應(yīng)邀綜述 </p><p>　　Liu, C. He., Y. and Chang Z. , Truncated hemoglobin of Mycobacterium tuberculosis: The oligomeric state change and the interaction with membrane comp

96、onents , Biochem Biophys Res Commun. , 2004 , 316:1163-1172. </p><p>　　Liu Y., Fu, X., Shen, J., Zhang, H., Hong, W., and Chang, Z. , Periplasmic proteins of Escherichia coli are highly resistant to aggregat

97、ion: A reappraisal for roles of molecular chaperones in periplasm , Biochem Biophys Res Commun. , 2004 , 316(3):795-801. </p><p>　　Abulimiti, A., Fu, X., Gu., L., Feng, X., and Chang, Z. , Mycobacterium tube

98、rculosis Hsp16.3 nonamers are assembled and re-assembled via trimer and hexamer intermediates , J Mol Biol. , 2003 , Volume 326, Issue 4, 28 February 2003, Pages 1013-1023 , [Full Text] </p><p>　　Fu, X. Liu,

99、 C., Liu, Y., Feng, X., Gu, L., Chen, X., and Chang, Z. , Small Heat Shock Protein Hsp16.3 Modulates Its Chaperone Activity by Adjusting the Rate of Oligomeric Dissociation , Biochem Biophys Res Commun. , 2003 , 310(2):4

100、12-420. </p><p>　　Abulimiti, A., Qiu, X., Chen, J., Liu, Y., and Chang, Z. , Reversible methionine sulfoxidation of Mycobacterium tuberculosis small heat shock protein Hsp16.3 and its possible role in scaven

101、ging oxidants , Biochem. Biophys. Res. Commun., , 2003 , 305(1):87-93. </p><p>　　Gu, L., Abulimiti, A., Li, W., and Chang, Z. , Monodisperse Hsp16.3 nonamer exhibits dynamic dissociation and reassociation, w

102、ith the nonamer dissociation prerequisite for chaperone-like activity , J Mol Biol. , 2002 , Volume 319, Issue 2, 31 May 2002, Pages 517-526 , [Full Text] </p><p>　　Dai, H., Mao, Q., Yang, H., and Chang, Z.

103、, Probing the Roles of the Only Universally Conserved Leucine Residue in the Oligomerization and Chaperone-like Activity of Mycobacterium tuberculosis Small Heat Shock Protein Hsp16.3 , J. Protein Chem.,（new name: Protei

104、n J.) , 2000 , 19(4):319-326. </p><p>　　Yang, H., Huang, S., Dai, H., Gong, Y., Zheng, C., and Chang, Z. , The Mycobacterium tuberculosis small heat shock protein Hsp16.3 exposes hydrophobic surfaces at mild