Octopirox中間體4-甲基-6-(2，4，4-三甲基戊基)-2-吡喃酮的合成及相關(guān)比熱容的測(cè)定.pdf

1、浙江大學(xué)化學(xué)工程與生物工程學(xué)系碩士學(xué)位論文Octopirox中間體4甲基6（2，4，4三甲基戊基）2吡喃酮的合成及相關(guān)比熱容的測(cè)定姓名：李倩申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：化學(xué)工程指導(dǎo)教師：戴立言20100311浙江大學(xué)碩士學(xué)位論文ABSTRACTABSTRACTOctopiroxisakindofpowerfulanti—dandruffagentwithadvantagesonremovingdandruffoverotheronesIth

2、asgoodcooperationwithothercomponentsofshampooAnditissafetopeoplewithnostimulation，notoxicSo，OctopiroxhasgreatapplicationvalueInthisstudyasynthesisroutewithhigheryieldandpracticableoperationhasbeenchosenbasedonsynthesisme

3、thodofsimilarcompoundsfor4methyl6(2，4，4trimethylpentyl)2pyrone，whichisanimportantintermediateofOctopiroxItispreparedwith35，5一trimethylhexanoylchlorideandmethyl3methyl一2butenoatebyacylchlorination，F(xiàn)Cacylation，hydrolysisan

4、diactonization，reaction，andthetotalyieldis52％Theeffectsoftemperature，amountofcatalystsandtheratioofsubstrateineachstephavebeeninvestigated，andthesuitableconditionsfortheprocesshavebeenobtainedAndalso，heatcapactitesforcor

5、relatedcompoundsofsynthesisofOctopiroxhavebeenstudiesinthispaperHeatcapacitiesofbinarymixturesofaceticacidwithaceticanhydrideandmethenamineweremeasuredbycoolingmethodwithasimplecalorimeterfrom30815Kto33315Katatmosphericp

6、ressurewithdifferentcompositionsThevaluesofCpiscorrelatedwithtemperaturesandmolarfraction，andtheRMSDbetweentheexperimentalandcalculatedvaluesis046％and147％separatelyTheexcessmolarheatcapacitiesc；ofthebinarymixtureofacetic

7、acidwithaceticanhydridewerecalculatedfromtheexperimentaldata，andwerefittedtotheRedlich—Kisterequation，andtheAADbetweenexperimentalandcalculatedvaluesis568％Keywords：Octopirox；4methyl6一(2，4，4trimethyl)一2一pyrone；synthesis；h