2-[N-（取代苯胺基）]-5-（3，4，5-三甲氧基苯基）-1，3，4-噻二唑的合成與生物活性研究.pdf

1、貴州大學(xué)碩士學(xué)位論文2[N（取代苯胺基）]5（3，4，5三甲氧基苯基）1，3，4噻二唑的合成與生物活性研究姓名：謝兵申請學(xué)位級別：碩士專業(yè)：有機(jī)化學(xué)指導(dǎo)教師：宋寶安20071201貴州大學(xué)2007屆在職碩士學(xué)位論文SynthesisandBioactivityofNovel1，3，4ThiadiazoleDerivativesAbstract：1，3，4thiadiazolecompoundsunderthecurrentstudydi

2、splayfungicidal，herbicidal，insecticidalandantiviralactivitiesaswellashighselectivityhigllbiologicalactivitylowtoxicityandfriendshipwiththeenvironmentthroughtheresearchandexploitationsinmedicinesandpesticidesAsaresult，com

3、poundscontaining1，3，4thiadiazoleareattractingmuchattentioninthefieldsofpesticidesandmedicinesInordertoexplorethenovelderivativesof1，3，4thiadiazolecompoundswithhigherbiologicalactivities，weusedpyogallolicacidasastartingma

4、terialWedesignedandsynthesizedaseriesofnewcompoundsbymakinguseofthebioactivesubstructureandthebioisotericprincipleNinenew2一(substitutingphenylamineyl)5(3，4，5一trimethoxyphenyl)一1，3，4thiadiazolederivativesweresynthesizedfr

5、omgallicacidthroughfivesteps：etherification，esterification，hydrazidation，thiocarbamidefication，andcyclizationH3C0Ⅲ——RR：H；4CH3；2CH3；4OCH3；4F；2一F；4C1；4一Br；3一BrThestructuresofthetargetcompoundswereconfirmedbyIR，1HNMR，13CNMR

6、andelementalanalysisPreliminarybioassaysshowedthatallthecompoundshadsomeantifungalactivitytoGibberellazeae(Schw)PetchandfusariumoxysporumandValsamaliattheconcentrationsof50mg／Land500mg／LKeywords：1，3，4thiadiazole；pyogallo