大葉魚骨木和豬肚木化學(xué)成分及藥理活性研究.pdf

1、廣西師范大學(xué)碩士學(xué)位論文大葉魚骨木和豬肚木化學(xué)成分及藥理活性研究姓名：王安偉申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：有機(jī)化學(xué)指導(dǎo)教師：尹文清陳光英20080401廣西師范大學(xué)碩士學(xué)位論文大葉魚骨木莖和豬肚木根的化學(xué)成分及藥理活性研究IIStudiesonchemicalConstituentsofCanthiumsimileCanthiumhridumtheirAntibacterialActivitiesAuth:WanganweiSupervis:

2、YinWenqingChenguangyingMaj:ganicChemistyResearchInterest:NaturalganicChemistryAbstractObjective:CanthiumsimileMerrC.hridumBl.aretwoofthefourCanthiumspeciesgrowinginChinarecdedasamedicinalplantpossessingantipyreticactivit

3、y.ToourknowledgeNophytochemicalinvestigationshavepreviouslybeencarriedoutinthisspecies.Itisveryusefulfdevelopingtheimptanttheybasisonexploitationofphytogenicpharmacologicalactivity.Method：Thefecastexperimentresultsonthec

4、hemicalcompositionshowthatthestemofC.similetherootofC.hridumpredominantlyconsistoftriterpene、alkaloid、anthraquinone、steroid、ganicacid、Phenol、carbohydrateetc.TheairdriedC.simileC.hridumarecrushedthenextractedby75%ethanol(

5、involumefraction).Afterevapationunderreducedpressureadarkgreenethanolextractwasobtained.TheextractwasmixedwithwaterextractedbypetroleumetherchlofmethylacetatenBuOHrespectively.Thentakeatestonantibacterialactivityofdiffer

6、entfractions.ThechlofmtheethylacetatefractionwasrespectivelysubjectedtocolumnchromatographyovermacropousresinnmalreversedphasesilicagelsephadexLH20preparationthinlayerchromatographyrecrystallizationrepeatedlytoobtainpure

7、compounds.Results:Onthebasisofcomprehensivespectroscopicdata(IR、ESIMS、1HNMR、13CNMR、DEPT、1H1HCOSY、HSQC、HMBC)physicalchemicalactersliteraturesthestructuresofthecompoundswereidentifiedascaruilignanD(1)lupeol(2)，βsitosterol(

8、315)，3βacetyloleanolicacid(4)(3β)28Nlup20(29)ene317diol(5)24dihydroxy36dimethylbenzoate(6)26dimethoxypbenzoquinine(7)，vanillicacid(817)，syringicacid(9)benzoicacid(10)24hexadienedioicacid(11)βdaucosterol(1222)friedelinol(