川木通化學(xué)成分與質(zhì)量評價研究.pdf

1、成都中醫(yī)藥大學(xué)博士學(xué)位論文川木通化學(xué)成分與質(zhì)量評價研究姓名：唐遠申請學(xué)位級別：博士專業(yè)：中藥學(xué)指導(dǎo)教師：萬德光2007-05成都中醫(yī)藥大學(xué)博士學(xué)位論文 5Abstract Abstract As a frequently used traditional Chinese herb, Chuan Mutong has the efficacy to induce diuresis to treat strangury and promo

2、te both menstruation and lactation. Though Chinese Pharmacopoeia (2005 editon) VolumnⅠprescripts its source is from the vine of Clematis armandii Franch.and C. montana Buch.-Ham.,according to literature and reference boo

3、ks, there are more than 10 same generic plants are also used as Chuan Mutong in China. Based on the textual research, the drug commodities of Chuan Mutong from 10 different provincial herb markets are collected and authe

4、nticated. On the other hand, combined with field investigation, specimen consultation and other relative materials, we organized the morphological characters, distributing and ecological enviroments of the plants (in Cle

5、matis, Ranunculaceae), which are used as Chuan Mutong in above-mentioned markets. So that we can further grasp the origin plants involved in drug commodities of Chuan Mutong. The acute toxicity of Clematis armandii’s ste

6、m is investigated by the experiment of Maximal tolerated dose on mice.The result shows that the maximal tolerated dose for mice is 532g/kg, which is 5320 times of human daily use,and there were no death and toxic reactio

7、n in 7 days of observation.So, we tentatively think that Clematis armandii’s stem has comparative safety in clinical use. It’s the first time to use the efficacy of inducing diuresis as evaluation index to screen the eff

8、ective part of Clematis armandii’s stem. We also compared different kinds of Mutong’s ability to promote diuresis and tentatively probe into Clematis armandii ’s diuresis mechanism by study the change of the content of e

9、lectrolyte in urine and ANF in blood plasma. The chemical components in the stem of Clematis armandii are investigated by systemic primary experiments and followed by extraction and seperation. 6 components have been sep