液-液萃取法分離α-氰基-3-苯氧基芐醇及其乙酸酯.pdf

1、浙江大學(xué)碩士學(xué)位論文液液萃取法分離α氰基3苯氧基芐醇及其乙酸酯姓名：陳永進(jìn)申請學(xué)位級別：碩士專業(yè)：化學(xué)工程指導(dǎo)教師：楊立榮20060301浙江人學(xué)碩一L學(xué)位論文ABSTRA(了ABSTRACT(s)一oL—Cyano一3phenoxybenzylalcohol((s)一CPBA)isanimportantchiralbuildingblockforthepreparationofmanyhigh—levelactivitypyrethr

2、oidinsecticidesItsopticallyactivederivatives，suchasa—hydroxyacid，a—hydroxyketoneandBhydroxyamine，areimportantfortheproductionofpharmaceuticalsandagrochemicalsManymethodscanbeusedtOprepare(S)一CPBAAmongthem，thelipase—catal

3、yzedasymmetricalcoholysisofa—Cyano一3phenoxybenzylacetate(CPBAc)shouldbeespeciallymentionedbecausehighopticallypure(S)CPBAcanbeobtainedThisreactionisshowninschemelDuringtheresolutionofracemicCPBAcbyalcoholysis，(S)一CPBAcwo

4、uldbedeacylatedpreferablyiflipaseshowedhighenantioselectivityTheundesired(R)一CPBAccanbeeasilyracemizedandreusedFromScheme1，itcanbeindicatedthatthekeysteptOensurethecycleoftheresolutionistOseparate(S)一CPBAfrom(R)CPBAceffi

5、cientlyInourexperiment，separationofCPBAfromCPBAcbyliquid—liquidextractionwasinvestigatedTheeffectsofthespeciesandvolumeratioofsolventsonthedistributioncoefficientsandsolubilityofCPBAandCPBAcinseveralextractionsystemswere

6、alsostudiedFurthermore，effectsoftemperatureandpHofwateronthestabilityofCPBAweredeterminedThrou【ghscreening，water：methanol：n—hexane：benzene=3：7：7：3(volumeratio)wasselectedasanefficientextractionsystemtoseparateCPBAfromCPB

7、AcAt25℃，after5extractionstages，thepurityofCPBAcintheorganicphasewas952％(m01)andtheyieldreached806％：andthepurityofCPBAintheaqueousphasewas988％(m01)andtheyieldreached626％Theorganicphasewasdehydratedandvacuumdistilledtogetp