托尼卟吩結構模型中B-C二吡咯結構單元的合成.pdf

1、南京理工大學碩士學位論文托尼卟吩結構模型中BC二吡咯結構單元的合成姓名：朱燕申請學位級別：碩士專業(yè)：應用化學指導教師：胡炳成20090525Abstract碩L論文AbstractTolyporphinisaHndofnaturallycyclictetrapyrroleswhichhavemanykindsofbiologicalactivitiesItplaysanimportantroleonantitumourtreatment

2、，chemicaltreatmentandphototherapyofcancerSOtheresearchonitssynthesisandapplicationispresentlyanimportantstudycontentandhotspotsofthechemistryofnaturalproductsInthisdissertation，themethodstosynthesizetolyporphinmodelandit

3、ssegmentsweresummarizedthroughtheanalysisandcomparisontovarioussynthesismethodsofchlorinsandpyrrolederivativesThetotalsynthesiswayofthetolyporphinmodelwasdesignedaccordingtothe“31”synthesismethodThesynthesisoftwopyrroled

4、erivativesandadipyrrylmethenewerestudied，thatweretheringB，Cbuildingblockofthetolyporphinmodel一3methyl2一oxygenmixed一1Hpyrroleandethyl3bromo5formyl一4一methyl—l融pyrrole2carboxylate，andB—Cbuildingblockofthetolyporphinmodel(Z)

5、ethyl3bromo一4一methyl5((4methyl一5OXO一1H—pyrrol2(5H)ylidene)methyl)1H—pyrrole2carboxylateThesynthesisofB—Csemichlorinwasprepared、ⅣithringBwhichhasAlphapositionvacancyandringCwhichhasAlphapositionlinked、析ththeformacylundert

6、healkalinityconditionringBbuildingblockwasproducedwithdiethyloxalacetateandaminoacetonethroughtheKnorrcondensation，thenbywayofdecarboxylandtheoxidation，thetotalyieldofringBWas204％：ringCbuildingblockWaspreparedfromrawmate

7、rialssuchasacetoaceticesterethyl—formiateandmethylethylketonethroughthenitrosation，theclaisencondensation，KnorrcondensationandthenbrominationandtheformylationthetotalyieldoffingCWas464％Thestructuresofthesyntheticproducts

8、werecharacterizedbyinfrared，1Hnuclearmagneticresonance，gaschromatographyandmassspectraTheresultscametothefollowingconclusions：thesynthesiswaysofthetargetcompoundswerescientific、rationalandbrief，alsohadmildreactionconditi