年齡小于或等于40歲的中國年輕胃癌患者臨床特點分析.pdf

1、華中科技大學碩士學位論文年齡小于或等于40歲的中國年輕胃癌患者臨床特點分析姓名：阿吉申請學位級別：碩士專業(yè)：臨床醫(yī)學內(nèi)科學(消化內(nèi)科)指導教師：朱良如201105華中科技大學碩士學位論文4關(guān)鍵詞：胃癌，臨床特點INTRODUCTIONGastriccarcinomaisoneofthemostcommonmalignancieswldwide.Althoughtheincidencerateofgastriccancerhasbeend

2、ecliningsteadilygastriccancerremainsthesecondmostcommonmalignanttuminthewld(12)contributestosignificantcancermtalityparticularlyinAsia(ChinaJapanKea)partsofEuropeLatinAmerica.MultipleenvironmentalfactsincludingHelicobact

3、erpyliinfection(3)dietaryfacts(4)havebeenimplicatedintheinitiationofgastriccarcinogenesis.Itoccursmainlyinelderlypatientswithapeakincidenceover60yearsofage(5).Gastriccanceroccurringinyoungpatientsalsodesignatedasearlyons

4、etgastriccancer(EOGC)accountsflessthan8%ofallcancersdevelopinginthestomach(6).ControversialdataarereptedintheliteratureregardingtheclinicopathologicalfeaturesprognosisofEOGClittleisknownaboutitsprofileinEuropeanpopulatio

5、ns(7).Inothergeographicregions(Japan(8)Taiwan(9)Kea(10)USA(11)Mexico(12)SouthAfrica(13)EOGCsoccurpredominantlyinwomenmostarediffusecarcinomasaccdingtoLauren’s(14)classification.Regardingtheprognosisofthediseasesomestudie

6、ssuggestedthatyoungpatientshaveapoprognosis(913)duetodelayeddiagnosisaggressivebehaviwhereasotherstudiesindicatedthatclinicaloutcomeismainlydependentonstageatdiagnosisregardlessoftheageofthepatients(7811).Thepoprognosiso

7、fgastriccancercanlargelybeattributedtolatepresentationdiagnosis.IncontrasttotheWestJapanhasintroducedsystematicmassscreeningprogrammeswhichhaveledtoincreaseddetectionratesofgastriccancersconfinedtothemucosasubmucosa(soca