P16、pRb和Survivin在乳腺癌中的表達(dá)及其臨床意義.pdf

1、山西醫(yī)科大學(xué)碩士學(xué)位論文P16、pRb和Survivin在乳腺癌中的表達(dá)及其臨床意義姓名：石武山申請學(xué)位級別：碩士專業(yè)：普通外科指導(dǎo)教師：牛清華20080405山西醫(yī)科大學(xué)碩士學(xué)位論文TheexpressionoftheP16，pRbandSurvivinitsclinicalsignificanceinbreastcancerandAbstractObjective：Toprobetheexpressionwhichtheprotei

2、nsofthemultipletumorsuppressorgenes(p16)，retinoblastomagene(Rb)andapoptosisinhibitoryproteingene(Survivin)inbreastcancertissue，AndtheyarerelatedtOtheclinicalindicatorsoflymphnodemetastasisandtumorstageandSOonMethods：Usin

3、gimmunohistochemicalmethodsinvestigatestheexpressionsofp16、pRbandSurvivinin60casesofbreastcancerResults：Thepositiveexpressionrateofthep16proteinwas45％(27／60)inbreastcancer，itwaslownegativecorrelationwithlymphnodemetastas

4、is限=一0289；p=0025)，andwasnegativelycorrelatedwithTNMstaging(R=一O369；p=0004)，andwerepositivelycorrelatedwiththedegreeofdifferentiation(R=O271；p0036)；ThepositiveexpressionrateofthepRbwas65％(39／60)，itwaslownegativecorrelatio

5、nwithlymphnodemetastasis(R=一0301；p=O019)，andwerepositivelycorrelatedwiththedegreeofdifferentiation(R=O282；p=0029)；ThepositiveexpressionrateoftheSurivinproteinWas433％(26／60)inbreastcancer，itWaslownegativecorrelationwithly

6、mphnodemetastasis(R=0284；p0028)，andwasnegativelycorrelatedwiththedegreeofdifferentiation(R=一O312；p=0015)TheexpressionoftheP16hadnosignificantcorrelationwithtumortypeandageofonset(P005)，theexpressionsoftheSurvivinandpRbha

7、dnosignificantcorrelationwithtumortype、stageandageofonset(P005)Conclusion：(1)Theabnormalexpressionofthep16、pRbandofSurvivinwascloselyrelatedtotheoccurrenceofbreastcancer(2)TheexpressionWasanegativecorrelationbetweenp16an

8、dpRb，SurvivinandpRb(3)Theexpressionofthep16wasrelatedtOlymphnodemetastasis、TNMstage，thedegreeofdifferentiation，theexpressionoftheSurvivinandpRbwasrelatedtOlymphnodemetastasisandthedegreeofdifferentiationinbreastcancer(4)

9、Theabnormalexpressionofp16、pRbandSurvivinwasacertainomentotransformationfromthebenignbreasttOthemalignant，andthecombineddetectionofthemwillhelpdeterminetheprognosisofthebreastcancerKeywords：breastcancergene，p16，pRb，Survi