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1、山西醫(yī)科大學(xué)碩士學(xué)位論文NRP1在胰腺癌的表達(dá)及其與MVD的相關(guān)性研究姓名：崔瀟龍申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：普通外科指導(dǎo)教師：劉建生鮑民生20070510山西醫(yī)辯大學(xué)碩士學(xué)位論文ExpressionandtheCorrelationStudyofNRP1andMicrovasculardensityinpancreaticcancerAbstractPancreaticCanCel“isoneofthemostmalignantfamil

2、iaralimentarytractcancerwhichhavehi曲malignantdegreeandearlymetastasis，incidenceofadiseasewentonandonintherecent20yearsThekeycausationofthetumor’developmentisthegrowthofthetunlor’bloodvesselWhilethegrowthofthetumor’bloodv

3、esseldependonregulationanddominationoftheSOmanyvasculargrowthfactorsVascularendothelialgrowthfactor(VEGFforshort)isthemostsignificantvasculargrowthfactorswhosecoreceptorNRPIhasbeenthehoupotofthestudyatpresentWeintendtodi

4、scusstheexpressionandthecorrelationofNRP1andMicrovasculardensityinpancreaticcancernowObjectivesTheaimofthestudywastoinvestigatetheexpressionoftheNRP一1andtoexplorethepossiblecorrelationwithMicrovasculardensityinpancreatic

5、cancerMethodsWehadselectedembeddedspecimensfrom40patientswhounderwentoperationforpancreaticcancer(excludeperampullaryadenocarcinoma)inthefirstaffiliatedhospitalofShanXimedicalUniversityandShahXitumorhospitalfrom1999March

6、to2005OctoberWhichincludedmalewere22easesandwerefemale18casesnlelocationofthetumorwerethatcancerofheadofthepancreaswere25casesandcarlcerofbodyandcaudaoftoepancreaswere15casesThepathologictypewasthathighWasIcase，middledif

7、ferentiationwere24casesandlowdifferentiationwere15caseswhiletherewere15casashadlymphaticmetastasisWewouldhavetoselectanother25specimensofnaturalpancreatictissuetocomparethepancreaticcancermentionedaboveImmunohistochemica

8、lmethodWasusedtodetectallofthespecimens’expressionoftheNRP一1andMicrovasculardensity(MVDforshort)TheintensionoftheNRP1’expressionWasdetectedbyaverageraydensityThemethodofcaculatedMVDwewouldrefertothemethodwhichWeidnerandM

9、aedahadreportedElectedthelocationofthehighestdensityoftumorbloodvesselin100XThenelectedbrowncoloredendothelialcellorcellclusterwhichweredifferentfromothertumorcellandconnectivetissueobviouslyasonebloodvseeslunitWewouldca

10、culatequantityofthebloodvseeslunitin5fieldsofvisionandmakeanaverageonthatResults(1)ThepositiverateofNRPIexpressioninpancreaticcancerwas925％(37／40)andthatiIlnormalOrbenignlesionpancreatictissuewas8％(2／25)ThereWasstatistic

11、aldifferencebetweenthem(p0001)(2)ThequantityofMVDinpancreaticcancerandnormal01“benignlesionpancreatictissuewere46704=6454、23084426，respectivelyThereWasstatisticaldifferencebetweenthem(pO05)(3)ThereWasnosignificantdiffere

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