COX-2、VEGF、E-cadherin在甲狀腺癌中的表達及其臨床意義.pdf

1、山西醫(yī)科大學碩士學位論文COX2、VEGF、Ecadherin在甲狀腺癌中的表達及其臨床意義姓名：任晉軍申請學位級別：碩士專業(yè)：腫瘤學指導教師：米玉錄20100315山西醫(yī)科大學碩士學位論文ExplIessionofCOX一2，VEGF，E—cadherinint11yroidcaIcinomaandItsclinicalSignificanceAbstractobjec晰e：TosnldytheeXpressionofCOX一2，E—

2、cadh甜n觚dvEGFiIlmyroidcarcinoma鋤ditsclinicalsi薩ificanceMethods：ExpressionofCOX一2，E—cadh葫nandVEGFwaSdetectedin68c嬲es嘶m燦喲idc孤試noma，l6caseswithth)rroidadenomaLs鋤d16caSesofnomlalthyroidtissllesby2一StepPluSi加munollistochemical

3、method鋤dFindⅡlerelationsbetⅣeeIlCOX2，Ecadh耐n，VEGF趾dthyroidcardnoma’shistolo垂calstage，TNMstageS，patllolo百caltype，lymphnodcme1【astasiss紈sResults：1TheexpressionofCOX2，Ecadh甜nandVEGFin68cas髓wimtllyroidc鋤ciIlomawas632％，662％an

4、d618％respectiVely，h嬲si嘶1cicantdif釹饑ce(P≮O05)C0mparedwimttleexpressionofnleseproteinsintllyroidadellom勰鋤dn鋤alⅡlyroidtis跚es2TheeXp鼻齬sionofCoX一2，Ecadh甜naIldVEGFw嬲si鰣16icantlydi腦entwimllistolo百calstageTNMStages’pamolo舀caltyp

5、eandwithlyrnphnodemec嬲tausisstatIls(P005)3nleeXprcssionofE—c棚l甜nwasneg；ltiVdyc0盯elatedwimtlleeXpreSsionofVEGFandCOX_2釁0423，r=0413，P001)ExpressionofCOX2w嬲positiVelyrelatedtotheeXpressionofVEGF(產(chǎn)0659，POO1)4BySiIl舀efac柵aIla

6、lysis，tlleexpressionofCOX一2，Ecadherin鋤dVEGFinmymidc觚cef，mesuⅣiValmtedi虢蚴Cesb帆eeIlnegatiVea11dpositive印upshadstatisticalsi鰣fic孤船(P005)COX一2觚dVEGFpositiVegroupwerewithbadpr0朗osis，Ecadh甜nnegatiVe印upwaswith900dpro朗osis5BymuI

7、tiV撕ate觚alysis，theexpressionofCOX2，Ecadh耐n鋤dVEGF，llistolo百calstage，TNMstages，pa協(xié)olo孚caltⅥe，lymphr10demet嬲tasisSt咖saretlleindepentpro粵losisfactorsthataffectingthyroidcardnomapatieI】臨’sIlⅣiValfateConclusion：CoX一2，E—cadh嘶na

8、IldVEGFplay鋤iml，ortantroleincarcinogeIl鼯is鋤dde、，elopmemofmyroidcarCinomaComM功eddetectioncaIIpr0VideVdludbleevidenceforestimationof蚪essiVede孕eeandprognosisofthyroidc刪nomaKeywords：thyroidcarCinoma，COX2，Ecadh嘶n，VEGF，immllIl