重癥細(xì)菌感染兒童血清瘦素的改變.pdf

1、青島大學(xué)碩士學(xué)位論文重癥細(xì)菌感染兒童血清瘦素的改變姓名：程玉先申請學(xué)位級別：碩士專業(yè)：兒科學(xué)（兒內(nèi)）指導(dǎo)教師：李堂2002.4.10英文摘要THECHANGESOFSERUMLEPTINCON—CENTRATIONSDURINGSEVEREINFEC—TIOUSDISEASESWITHBACTERIAINCHlLDRENABSTRACTObjectiveInfectiousdiseases(ID)ismostcommondiseases

2、inchildren7FheseverityofHDdependsonthepathogenicityofdifferentpathogenAndmostimportantly，itdependsonthestatusofimmunologicalfunctionLeptinisaproteohormoneencodedbytheobesegeneandproducedbyadipocytes，whichisinvolvedwithme

3、tabolismItisre—centlyreportedthatleptinlevelsareelevatedwithincreasingcytokines，especially’FumorNecrosisFactorAlpha(TNF—a)，endotoxinandglucocorticoidItisalsorepor—tedthatleptinlevelsaredecreasedinIDThisstudydetectedlepti

4、nand‘IN17aduingse’vereIDwithbacteriatOclarifythecorrelationbetweenleptinandID，andanalyzethemechanismandsignificanceofthechangeMethodLeptinandTNFaduringacuteandrecoveryphasesweredetectedbylm—nmnoradiometricAssay(IRMA)andE

5、nzymeAmplifiedSensitivityInlnlunoassay(EAS一1A)in33severeIDwithbacteria，respectively，andtheresultSwerecomparedwithcontrolgroupLeptinandTNF—alevelsofdifferentIDwereanalizedbylinearcorrelationa—nalysisResultsLeptinlevelsins

6、evereIDwitbbacteriawerelowerduringacutephasesthanthoseincontrolgroup(PO05)，andincreasedgraduallyduringrecoveryphasesTNF—alevelsduringacuteIDweresignificantlyhigherIhanthoseduringrecoveryphasearidthoseincontrolgroup，respe

7、ctively(PO001)Leptinlevels，inacuIe11)，werenegnIivecorrelativewith’INFaanddependontheseveritYofinfectionConclusion“／hisstudyshowsthatleptinlevelswerPdownregtdatedduringacuteIDinhiman，andhaveanegativecorrelationwithTNtalev

8、elsDetectingleptinCODCCOIrationsisofgreatsignificancetOthejudgementofthe：everityofII)1~heresultspro、idedobjectiredatafortheendocrineandimmunologicalnelworkKEYWORDS：InfectiousDiseases(ID)；children；leptin；TNFa；IRMAEASIAPos