異甘草酸鎂抗炎作用機(jī)制研究鐘才云

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7、臨床應(yīng)用于抗炎、保護(hù)肝臟 抗炎作用機(jī)制尚待研究,Magnesium Isoglycyrrhizinate異甘草酸鎂（甘美）,甘美抑制LPS誘導(dǎo)的炎性細(xì)胞因子水平(RAW264.7),甘美抑制LPS誘導(dǎo)的NO、iNOS水平(RAW264.7),甘美抑制 LPS誘導(dǎo)的cPLA2(RAW264.7),甘美抑制花生四烯酸代謝酶水平（RAW264.7）,甘美抑制花生四烯酸代謝脂質(zhì)炎癥介質(zhì)（RAW264.7）,甘美對(duì)NF-κB活性的抑制作

8、用（RAW264.7）,甘美對(duì)MAPK活性的抑制作用（RAW264.7）,PBS,DMSO,PBS+LPS,DMSO+LPS,MgIG 0.5+LPS,DEX10-6+LPS,HYD10-4 +LPS,DEX10-5+LPS,HYD10-3 +LPS,MgIG 1+LPS,免疫熒光,甘美對(duì)細(xì)胞內(nèi)ROS水平的抑制作用（RAW264.7）,甘美對(duì)細(xì)胞內(nèi)ROS水平的抑制作用（RAW264.7）（流式細(xì)胞術(shù)）,甘美對(duì)血清中細(xì)胞因子水平的影響（

9、小鼠）,甘美對(duì)炎癥模型肝臟中細(xì)胞因子和NO的影響（小鼠）,甘美抑制肝臟中PLA/AA介導(dǎo)的炎性介質(zhì)（小鼠）,甘美抑制LPS誘導(dǎo)的NF-κB 和 MAPK活性（小鼠）,甘美劑量依賴(lài)性地抑制由炎癥刺激誘導(dǎo)的PLA2/AA、NF-κB 和MAPK 關(guān)鍵炎性反應(yīng)信號(hào)通路的活性； 甘美明顯降低由炎癥信號(hào)調(diào)控的炎性反應(yīng)酶 （PLA2、COX-2、LOX、 iNOS）、脂質(zhì)炎癥介質(zhì)（前列腺素、 血栓素、白三烯 ）、 細(xì)胞因子