生物藥劑學與藥物動力學習題及答案1-15章

1、Delegatesstaff:Hello!intherunuptotheSpringFestivalweheldonesessionoffourstaffrepresentativesConference2013wkshopfullbackin2012carefulanalysisofthecurrentsituationdiscuss2013developmentplans.Hereonbehalfofmycompany2013wkr

2、eptstotheGeneralAssemblyfconsideration.PillarI2012backin2012XXpowercompaniesadheretothepartys17greatspiritfguidancecomprehensivelyimplementthescientificconceptofdevelopmentpromotingcostleadershipstrategystardsfocusonimpl

3、ementationleanmanagementcontinuouslyimprovesmoothpresentsafetysituationofenterprisemanagementbusinessmanagementcontrolscientificstardizedthededicationofstaffmanageaharmoniousdemocraticatmosphereofthegoodsituation.Mainind

4、icatsareasfollows:thebatteryindicat:powergenerationtotaled7.815billionkWhbeyondtheannualbudgetimplementationcapacityof315millionkWhanincreaseof757millionkWh.Salestotaled7.425billionkWhexceedingsalesof330millionkWhtheannu

5、alExecutivebudgetanincreaseof729millionkWh.Securitymeasures:unplannedoutages2.5times.Nopersonalinjuryaccidentoccurrednomajaccidentabovenomajfireaccidentswithoutenvironmentalpollutionaccidentssafetyfthreeconsecutiveyearst

6、omaintainstabilitytogoodposture.–Businessfinancialindicats:totalprofitsof255millionYuanbeyondtheannualbudgetof207millionYuanbeyondtheDatangcompanyindex41.89millionYuananincreaseof1.76millionYuanFCMassessmentatgradefour.E

7、nergy:powersupplystardcoalcompleting312.25gkWhdown0.1gkWhintegratedauxiliarypowerconsumptionratioin5.12%down0.26%pollutantemissionsperfmancegreatlyreducedcomparedtolastyearcarbon0.09gkWhsulfurdioxide0.104gkWhNOx0.512gkWh

8、dustremovalefficiencyofmethan99.8%.Reliabilityindex:equivalentavailabilityfactin93.47%increased7.95%fromayearearlier.Equivalentfcedoutagerate0.08%0.16%reductionoverthesameperiodayearearlier.Majachievements:firstweshoulda

9、dheretothetwo“managementsystem“basisstrengtheningtechnologicalresearchstrengthenhiddenhazardscontrolintrinsicsafetyEnterpriseconstructiontooknewsteps.Thetwo“managementsystem“fimprovement.Focusonpromotingthepowerofthecomp

10、anymanagementsystemtheapplicationimplementationofthesafetyloopfivestarmanagementsystemimprovethesafetymanagementsystemrealizethesystemofsafetycontrol.Furtherregulatesecurityroutinessafetysupervisionmanagementwkroletoplay

11、toachieveclosedloop.Strengtheningthesupervisionmanagementofhabitualviolationofstrengtheningthesafetysupervisionofoutsourcingcontracts.Carriedoutinspringautumnofsecurityinspectionsfloodcontrolinspectionsafetyproductionmon

12、thdaysupervisionofproductionsafetytheOlympicGamesotheractivitiescomprehensivetampingSafetyFoundation...Troubleshootingmanagementmechanismgivefullplaytoroleoftechnicalsupervisionrealizationoftroubleshootingmanagementimpro

13、vedprocessmanagement.Thisyearcompletedtheboilerlowerheaderleakageboilerpressureamajriskmanagementcompleted29ofgreatrisks3Generalproblemsofgovernance.Completechemistrylabconstructionthermalcontrolcompletetheboilerscaleint

14、egratedmanagementhostshaftingvibrationof10scientifictechnologicalprojectssuchas.Completesupercritical630MWonlinesimulationsystemdevelopmentapplicationofcirculatingwaterMCCstbypowertransfmationthetransfmationofdesulfuriza

15、tionwastewatertheunitwatersupplysystemofcomprehensivetreatmentdisgevalvemodificationofcoalmill5keytechnologicaltransfmationprojectsgrouphealthisimproved.Sciencetechnologyinnovationisfurtherincreased.Strengthentheacterist

16、icsofsupercriticalunitmajissuesgraduallyclearingtheparticularityofsupercriticalunitregularity.Developedmotoiltimemanagementswitchactiontimesstatisticscoalaidedmeasurementsoftwareimprovestheproductionlevelofleanmanagement

17、.Increasedinvestmentinsciencetechnologyreptingsciencetechnologyprojects14technicalprojecttotalcostpercentageofthetotalannualproductionoutputof0.25%.“Largescalecoalfiredpowerplantfluegasdesulfurizationdenitrificationcompl

18、etedevelopmentapplicationofkeytechnologies“projectwonthenationalsciencetechnologyprogresssecondprize.630MWsupercriticalunitsoptimizedcontrolstrategiesthe630MWdevelopmentapplicationofonlinesimulationsystemfsupercriticalun

19、itssupercritical600MWunitsofturbinedrivenboilerfeedpumpsetofcomprehensivetreatmentofdefectsDatangtechnologyrespectivelyonetwothird.Meanwhileinfmationtechnologyachievementsthecompanywasnamed“Chinapowerinfmationtechnologyb

20、enchmarkingenterprises.“Repairmaintenancehasimprovedfurther.Modifytheinspectionstardsstardsonaregularbasisstardizingwkprocedurescheckinginspectionproject.DeepeningtheBFSsystemimplementsmaintenanceinfmationshared.Reganizi

21、ngRBlogicagainensurethesuccessoftheRB.Innovatingthemechanismofmaintenancemanagementimplementedaprojectmanagersystem.Successfulcompletionoftwoautonomousmaintenancereliabilityimprovedsteadily.Implementingtwoclevelmaintenan

22、ceprojectthemselves48.7%42.3%respectively.AccomplishtwocirculatingpumpsrepairoverhauloffourMillsmaintenanceteamstogetexercise.Promotethewkofenergysavingconsumptionreducingcompletetheunitenergyconsumptiondiagnosisplantwat

23、erbalancetest10energysavingprojects.Secondweshouldadhereto“three“ontheeconomicbenefitsofimprovingoutreach第一章生物藥劑學概述【習題】一、單項選擇題1以下關(guān)于生物藥劑學的描述，正確的是A.劑型因素是指片劑、膠囊劑、丸劑和溶液劑等藥物的不同劑型B.藥物產(chǎn)品所產(chǎn)生的療效主要與藥物本身的化學結(jié)構(gòu)有關(guān)C藥物效應包括藥物的療效、副作用和毒性D.

24、改善難溶性藥物的溶出速率主要是藥劑學的研究內(nèi)容2以下關(guān)于生物藥劑學的描述，錯誤的是A.生物藥劑學與藥理學和生物化學有密切關(guān)系，但研究重點不同B.藥物動力學為生物藥劑學提供了理論基礎(chǔ)和研究手段C.由于生物體液中藥物濃度通常為微量或痕量，需要選擇靈敏度高，專屬重現(xiàn)性好的分析手段和方法D從藥物生物利用度的高低就可判斷藥物制劑在體內(nèi)是否有效二、多項選擇題1藥物及劑型的體內(nèi)過程是指A.吸收B.滲透C分布D.代謝E排泄2藥物轉(zhuǎn)運是指A.吸收B.滲透

25、C分布D.代謝E排泄3藥物處置是指A.吸收B滲透C分布D.代謝E排泄4藥物消除是指A.吸收B滲透C分布D.代謝E排泄三、名詞解釋1生物藥劑學；2劑型因素；3生物因素；4藥物及劑型的體內(nèi)過程四、問答題1生物藥劑學的研究工作主要涉及哪些內(nèi)容？2簡述生物藥劑學研究對于新藥開發(fā)的作用?！玖曨}答案】一、單項選擇題1.C2.D二、多項選擇題1ACDE2ACE3CDE4DE三、名詞解釋1生物藥劑學：是研究藥物及其劑型在體內(nèi)的吸收、分布、代謝與排泄過程

26、，闡明藥物的劑型因素、機體的生物因素與藥理效應三者之間相互關(guān)系的科學。2劑型因素主要包括：(1)藥物的某些化學性質(zhì)：如同一藥物的不同鹽、酯、絡合物或衍生物，即藥物的化學形式，藥物的化學穩(wěn)定性等。(2)藥物的某些物理性質(zhì)：如粒子大小、晶型、晶癖、溶解度、溶出速率等。(3)藥物的劑型及用藥方法。(4)制劑處方中所用輔料的種類、性質(zhì)和用量。(5)處方中藥物的配伍及相互作用。(6)制劑的工藝過程、操作條件和貯存條件等。3生物因素主要包括：Del

27、egatesstaff:Hello!intherunuptotheSpringFestivalweheldonesessionoffourstaffrepresentativesConference2013wkshopfullbackin2012carefulanalysisofthecurrentsituationdiscuss2013developmentplans.Hereonbehalfofmycompany2013wkrept

28、stotheGeneralAssemblyfconsideration.PillarI2012backin2012XXpowercompaniesadheretothepartys17greatspiritfguidancecomprehensivelyimplementthescientificconceptofdevelopmentpromotingcostleadershipstrategystardsfocusonimpleme

29、ntationleanmanagementcontinuouslyimprovesmoothpresentsafetysituationofenterprisemanagementbusinessmanagementcontrolscientificstardizedthededicationofstaffmanageaharmoniousdemocraticatmosphereofthegoodsituation.Mainindica

30、tsareasfollows:thebatteryindicat:powergenerationtotaled7.815billionkWhbeyondtheannualbudgetimplementationcapacityof315millionkWhanincreaseof757millionkWh.Salestotaled7.425billionkWhexceedingsalesof330millionkWhtheannualE

31、xecutivebudgetanincreaseof729millionkWh.Securitymeasures:unplannedoutages2.5times.Nopersonalinjuryaccidentoccurrednomajaccidentabovenomajfireaccidentswithoutenvironmentalpollutionaccidentssafetyfthreeconsecutiveyearstoma

32、intainstabilitytogoodposture.–Businessfinancialindicats:totalprofitsof255millionYuanbeyondtheannualbudgetof207millionYuanbeyondtheDatangcompanyindex41.89millionYuananincreaseof1.76millionYuanFCMassessmentatgradefour.Ener

33、gy:powersupplystardcoalcompleting312.25gkWhdown0.1gkWhintegratedauxiliarypowerconsumptionratioin5.12%down0.26%pollutantemissionsperfmancegreatlyreducedcomparedtolastyearcarbon0.09gkWhsulfurdioxide0.104gkWhNOx0.512gkWhdus

34、tremovalefficiencyofmethan99.8%.Reliabilityindex:equivalentavailabilityfactin93.47%increased7.95%fromayearearlier.Equivalentfcedoutagerate0.08%0.16%reductionoverthesameperiodayearearlier.Majachievements:firstweshouldadhe

35、retothetwo“managementsystem“basisstrengtheningtechnologicalresearchstrengthenhiddenhazardscontrolintrinsicsafetyEnterpriseconstructiontooknewsteps.Thetwo“managementsystem“fimprovement.Focusonpromotingthepowerofthecompany

36、managementsystemtheapplicationimplementationofthesafetyloopfivestarmanagementsystemimprovethesafetymanagementsystemrealizethesystemofsafetycontrol.Furtherregulatesecurityroutinessafetysupervisionmanagementwkroletoplaytoa

37、chieveclosedloop.Strengtheningthesupervisionmanagementofhabitualviolationofstrengtheningthesafetysupervisionofoutsourcingcontracts.Carriedoutinspringautumnofsecurityinspectionsfloodcontrolinspectionsafetyproductionmonthd

38、aysupervisionofproductionsafetytheOlympicGamesotheractivitiescomprehensivetampingSafetyFoundation...Troubleshootingmanagementmechanismgivefullplaytoroleoftechnicalsupervisionrealizationoftroubleshootingmanagementimproved

39、processmanagement.Thisyearcompletedtheboilerlowerheaderleakageboilerpressureamajriskmanagementcompleted29ofgreatrisks3Generalproblemsofgovernance.Completechemistrylabconstructionthermalcontrolcompletetheboilerscaleintegr

40、atedmanagementhostshaftingvibrationof10scientifictechnologicalprojectssuchas.Completesupercritical630MWonlinesimulationsystemdevelopmentapplicationofcirculatingwaterMCCstbypowertransfmationthetransfmationofdesulfurizatio

41、nwastewatertheunitwatersupplysystemofcomprehensivetreatmentdisgevalvemodificationofcoalmill5keytechnologicaltransfmationprojectsgrouphealthisimproved.Sciencetechnologyinnovationisfurtherincreased.Strengthentheacteristics

42、ofsupercriticalunitmajissuesgraduallyclearingtheparticularityofsupercriticalunitregularity.Developedmotoiltimemanagementswitchactiontimesstatisticscoalaidedmeasurementsoftwareimprovestheproductionlevelofleanmanagement.In

43、creasedinvestmentinsciencetechnologyreptingsciencetechnologyprojects14technicalprojecttotalcostpercentageofthetotalannualproductionoutputof0.25%.“Largescalecoalfiredpowerplantfluegasdesulfurizationdenitrificationcomplete

44、developmentapplicationofkeytechnologies“projectwonthenationalsciencetechnologyprogresssecondprize.630MWsupercriticalunitsoptimizedcontrolstrategiesthe630MWdevelopmentapplicationofonlinesimulationsystemfsupercriticalunits

45、supercritical600MWunitsofturbinedrivenboilerfeedpumpsetofcomprehensivetreatmentofdefectsDatangtechnologyrespectivelyonetwothird.Meanwhileinfmationtechnologyachievementsthecompanywasnamed“Chinapowerinfmationtechnologybenc

46、hmarkingenterprises.“Repairmaintenancehasimprovedfurther.Modifytheinspectionstardsstardsonaregularbasisstardizingwkprocedurescheckinginspectionproject.DeepeningtheBFSsystemimplementsmaintenanceinfmationshared.ReganizingR

47、BlogicagainensurethesuccessoftheRB.Innovatingthemechanismofmaintenancemanagementimplementedaprojectmanagersystem.Successfulcompletionoftwoautonomousmaintenancereliabilityimprovedsteadily.Implementingtwoclevelmaintenancep

48、rojectthemselves48.7%42.3%respectively.AccomplishtwocirculatingpumpsrepairoverhauloffourMillsmaintenanceteamstogetexercise.Promotethewkofenergysavingconsumptionreducingcompletetheunitenergyconsumptiondiagnosisplantwaterb

49、alancetest10energysavingprojects.Secondweshouldadhereto“three“ontheeconomicbenefitsofimprovingoutreachE飽和現(xiàn)象6胞飲作用的特點是A有部位特異性B需要載體C不需要消耗機體能量D.逆濃度梯度轉(zhuǎn)運E以上都是7下列哪種藥物不是Pgp的底物A環(huán)孢素AB甲氨蝶呤C地高辛D諾氟沙星E維拉帕米8藥物的主要吸收部位是A胃B.小腸C大腸D.直腸E均是9關(guān)

50、于影響胃空速率的生理因素不正確的是A胃內(nèi)容物的黏度和滲透壓B精神因素C食物的組成D.藥物的理化性質(zhì)E身體姿勢10.在溶出為限速過程吸收中，溶解了的藥物立即被吸收，即為()狀態(tài)A.漏槽B動態(tài)平衡C.飽和D.均是E.均不是11.淋巴系統(tǒng)對()的吸收起著重要作用A.脂溶性藥物B解離型藥物C水溶性藥物D.小分子藥物E未解離型藥物12.有關(guān)派伊爾結(jié)(PP)描述錯誤的是A.回腸含量最多B≤10Vm的微粒可被PP內(nèi)的巨噬細胞吞噬C由絨毛上皮和M細胞（

51、微褶細胞）構(gòu)成D.與微粒吸收相關(guān)E與藥物的淋巴轉(zhuǎn)運有關(guān)13.藥物理化性質(zhì)對于藥物在胃腸道的吸收影響顯著，下列敘述中錯誤的是A藥物的溶出快一般有利于吸收B.具有均質(zhì)多晶型的藥物，一般其亞穩(wěn)定型有利于吸收C藥物具有一定脂溶性，但不可過大，有利于吸收D.酸性藥物在胃酸條件下一定有利于吸收；堿性藥物在小腸堿性的條件下一定有利于藥物的吸收E膽汁分泌常會影響難溶性藥物的口服吸收14.影響片劑中藥物吸收的劑型和制劑工藝因素不包括A.片重差異B片劑的崩