CyclinD3和CyclinE蛋白在舌鱗癌中的表達及與臨床生物學特征的關系.pdf

1、東北大學碩士學位論文CyclinD3和CyclinE蛋白在舌鱗癌中的表達及與臨床生物學特征的關系姓名：劉麗軍申請學位級別：碩士專業(yè)：生物化工指導教師：王莉紅20070101東北大學碩士學位論文TheExpressionofCyclinD3andCyclinEinTonguesquamousCellCarcinomaandtheRelationshipwithClinicalBiologicalCharacteristicsAbstrac

2、tTostudytheexpressionofcyclinD3andcyclinEproteinsintongueⅨIu鋤ol塔cellcarcinoma(TSCC)andadjacentnonc鋤oel0璐tissueand丘Ⅱ吐屺nnorcanalyzethecorrdationbetweentheexpressionofcyclinD3andcyclinEproteinsandpatient’Sclinicopathologica

3、lcharacteristicsinT$CCsweexaminedtheexpressionofcyclinD3andcyclinEproteinsin47cas囂ofTSCCand18casesofadjacentnOllCaDceiDustissueusingimmmohistochemicalstainingmethodOurresultsdemonstramtnoexpressionofcyclinD3andcyclinEpro

4、teinsin18casesofadjacentnoncanceroustissueswhilethepositiveincidenceagainstcyclinD3andcyclinEproteinsin47casesofTSCCwere5532％and9362％respectively口銣01)OverexpressionofeyclinD3p蛐inTSCCscorrelatedwiththefollowfactors：s銥，lym

5、phaticmetastasisandhistopathologygrade口如05)，butwasnotsignificantlyrelatedtoagemadtunlorsize口o05)OverexpressionofcyclinEpmteininTSCCshasnocorrelationwiththefollowfactors：age，sextumorsizelymphaticmetastasis，andhistopatholo

6、gygrade(Po05)Postivecorrelationwasfoundbetw嘲ovcrexpressionofeyclinEandcyclinD3proteins㈣05)OurresultsdenlontratethatoverexpressionofcyclinD3andcyclinEproteinsmayhasasynergeticeffectonthedevelopmentofTSCCandmightbeoneofthe

7、mostimportantfactorswhichinducecellsoverproliferationintuYflorsugggestingthatcellcycleproteinsalecloselyrel劬甜totumorigenesisofTSCC；eyclinD3pmteinmayplayanimportantroleinearlydiagnosesandprognosisserving勰molecularindexesI