雌、孕激素受體、CerbB-2在甲狀腺腫瘤中的研究.pdf

1、山西醫(yī)科大學碩士學位論文雌、孕激素受體、CerbB2在甲狀腺腫瘤中的研究姓名：郭晉鐸申請學位級別：碩士專業(yè)：外科學指導教師：李正中20040530山西醫(yī)爭丈學碩士學們t奎文ResearchOnEstrogenReceptorProgesteroneReceptorandCerbB2OncogeneinHumanThyroidTumorAbstractobjeetive：Toinvestigatetheexpl’essionandrela

2、tionshipofestrogenreceptor(ER)，progesteronereceptor口R)andCerbB2oncogeneinhumanthyroidtumorMethod：Wecollect54specimensofthyroidtumorwithagedistribution1673yearsold(average4436)Amongthemtherearemalignanttumor34example(4mal

3、e，30female)，thyroidadenoma10example(4male6female)，nodulargoiter10example(2male，8female)Histologyclassificationofmalignanttumors：papillarycarcinoma25exampleincludewithmetastasisoflymphnode11example，follicularcarcinoma6exa

4、mple，undifferentiatedcarcinoma3exampleByusingimmunohistochemicalSPmethoddetectalltissuesin24hoursasitwasresected，accordingtodepthofstainandpositivecellpercentagethecaseweredividedfivegradesResults：ThepositiverateofERwas8

5、261％(19／23)inpapillarycarcinoma，1667％(1／6)infollicularcarcinoma，3333％(1／3)inundifferentiatedcarcinoma，3000％(3／10)inthyroidadenoma1000％(1／10)innodulargoiterThepositiverateofPRwas8261％(19／23)，3333％(2／6)，0(0／3)，2000％(2／10)，

6、20oo％(2／lo)respectivelythepositiveofPRwas8261％(19／23)，16。67％(1／6)，0(0／3)，3000％(3／10)，20oo％(2／lo)respectivelyTheresultshowedthattheexpressionofERPRandCerbB一2inpapillarycarcinomawassignificantlyhigherthanothertumors(p005)e

7、xceptforERinundifferentiatedcarcinomaThepositiverateofE&PRandCerbB2inpapillarycarcinomawithmetastasisoflymphnodewaslowerthanthosewithno，buttherewasn’tsignificantdifferentAnalysisofstainintensitywefoundsignificantdiscrepa

8、ncybetweenpapillarycarcinomaandfollicularcarcinoma，adenoma，nodulargoiterinERexpressionTherewasalsosignificantdifferentbetweenpapillarycarcinomaandadenoma，nodulargoiterinPRexpressionAsignificantdiscrepancywasgotbetweenpap