利用STR位點分析全球人類主要族群的遺傳差異.pdf

1、中山大學(xué)碩士學(xué)位論文利用STR位點分析全球人類主要族群的遺傳差異姓名：吳寬衡申請學(xué)位級別：碩士專業(yè)：信息生物學(xué)指導(dǎo)教師：何淼20100608中山大學(xué)碩士學(xué)位論文利用SIR位點分析全球人類主要族群的遺傳差異HereditarydifferencesofworldwidehumanpopulationsrevealedbySTRanalysisMajor：BioinformaticsName：WuKuanhengSupervisor：HeM

2、iaoAssoProfAbstractPurpose：TIlispaperhopestorevealhereditarydifferencesan的nghumanpopulationsworldwidesystematicallyandmigrationpathwaysinhumanhistorybyusingseveralpopulationgeneticsmethodsandstatisticmethodswithSTRdataMe

3、thods：Allthe15STRdatafrom80humanpopulationsworldwidearecollectedfromthescientificjournalsTwolevelsofdatasethavebeenusedinpresentstudyThestandarddatasetincludes7STR(D8S1179、D21S11、TH01、D16S539、vⅥA、D18S51、FGA)datafrom80pop

4、ulationsandtheexpanddatasetincludes15STR(D8S1179、D2lSll、D7S820、CSFlPO、D3S1358、THOl、D13S317、D16S539、D2S1338、D19S433、vWA、TPOX、D18S51、D5S818、FGA)datafrom54populationsThegeneticdiversityanalysisbasedonthestandarddatasethasap

5、pliedprincipalcomponentanalysis，clustermethodaverageheterozygosityandratioofallelelengthvariance，AMOVhgeneticdistanceandphylogenetieanalysisinordertorevealthreelevelsofgeneticvariationwithinpopulationamongpopulations，amo

6、nggroupsResults：Principalcomponentanalysisandclustermethodsuccessfullyrepresentthegeneticsubstructureofworldwide80humanpopulations80populationshavebeenpartitionedinto5groupsEachgrouprepresentsthepopulationsintheMediterra

7、neanandMiddleEastregionEurope，AmericaAsiaAfricarespectively111eresultsofAverageheterozygosityandratioofallelelengthvariance，F(xiàn)isher’Sexacttest，AMOVArevealtheexistenceofgenetkvariationwithinpopulations，amongpopulationsanda