大孔樹(shù)脂吸附黃芩黃酮和布渣葉黃酮的的應(yīng)用基礎(chǔ)研究.pdf

1、廣州中醫(yī)藥大學(xué) 2010 屆博士學(xué)位論文 廣州中醫(yī)藥大學(xué)學(xué)位論文原創(chuàng)性聲明 廣州中醫(yī)藥大學(xué)學(xué)位論文原創(chuàng)性聲明 本人鄭重聲明： 所呈交的學(xué)位論文，是個(gè)人在導(dǎo)師的指導(dǎo)下，獨(dú)立進(jìn)行研究工作所取得的成果。除文中已經(jīng)特別加以注明引用的內(nèi)容外，本論文不含任何其他個(gè)人或集體已經(jīng)發(fā)表或撰寫(xiě)過(guò)的作品成果。對(duì)本文的研究做出重要貢獻(xiàn)的個(gè)人和集體，均已在文中以明確方式標(biāo)明并致謝。本人完全意識(shí)到本聲明的法律結(jié)果由本人承擔(dān)。 學(xué)位論文作者簽名 ＿＿＿＿＿ 日 期：

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3、： 年 月 日 廣州中醫(yī)藥大學(xué) 2010 屆博士學(xué)位論文 Foundmental oundmental Research esearch of of the the Sorption of orption of Flavonoids in lavonoids in Scutellaria baicalensis Scutellaria baicalensis Georgi Georgi and and Micro

4、cos paniculata Microcos paniculata L. on L. on Macroporous acroporous Resin esins Speciality: Chinese Traditional Medcine Author: LI Kun-ping Tutor: LI Wei-min Abstract Abstract Fundamental research of the sorption

5、of herbal active ingredient on macroporous resins plays an important role on its industrial application. As flavonids in Scutellaria baicalensis Georgi and Microcos paniculata L. as studied objects, this paper systemly i

6、nverstigated some common problems, such as the adsorption characteristic of macroporous resins on flavonoids, the sorption kinetics and thermodynamics, the fixed bed and fluidized bed sorption process, and the computer s

7、imulation of adsorption process. Study found that under the setted conditions, flavonids in Scutellaria baicalensis Georgi and Microcos paniculata L. sorption on macroporous resin similar monolayer adsorption, Langmuir e

8、quation could well describe their adsorption isotherms,which equivalent adsorption ΔH located between -75 and -5 KJ.mol-1 , the free energy change ΔG at -5 ~ -2 KJ.mol-1, the entropy change ΔS between -0.08 and -0.01 KJ.

9、mol-1. K-1; its characteristic separation factor RL between 0 and 1, and the adsorption process of is the physical spontaneous adsorption process. Meanwhile, the Kannan model can describe the sorption kinetics of flavono

10、ids in Scutellaria baicalensis Georgi on AB-8 and HPD-100 resin; and the adsorption process of flavonoids in Microcos paniculata L.on D101, NKA and HPD300 resin fitted the Lagergren kinetic model; their absorption proces

11、s affected by the film diffusion and particle diffusion, but the control step is the film diffusion process. The study also found that the kinetics of total flavonoids adsorption fitted the general laws of thermodynamics

12、 and kinetics, but affected by the interaction between the adsorbates, while, the adsorption kinetics of vitexin and isorhamnetin -3-O-β-rutinoside lack of regularity. In addition, through a comparative study of the fix

13、ed bed adsorption process and the fluidization adsorption process, due to the reduction of the film diffusion resistance, the equilibrium adsorption time was significantly shorter and the elution time was significantly l