P38MAPK信號(hào)傳導(dǎo)通路及TNF-α在鼻息肉組織中的表達(dá)及意義.pdf

1、學(xué)校代碼：10132學(xué)員編號(hào)：2003142中圖分類(lèi)號(hào)：R76525喲馨爸逢穹統(tǒng)INN￡RMONGOUAMEDICALCOLLEGE額：～：學(xué)位論文P38MAPK信號(hào)傳導(dǎo)通路及TNF一僅在鼻息肉組織中的表達(dá)及意義學(xué)科專業(yè)：研究生：指導(dǎo)教師：完成時(shí)間：耳鼻咽喉科學(xué)王相成李玲香教陶格陶呼教二oo六年五月授授9ABSTRACT0bjec慨Bydetect崦theeXpressionofP38mPK、P—P38MAPK姐d咖一口irIn8sai

2、酬ypsandtos硎ytheme幽teand嘴datel01eofP38MAPKsigd乜ar劃uctionand口岍一ahf0HmtionofnasalpcdypsMethD凼D瞄氆婦ofP3熟壓A瞰、P—P38MAPKandn舊一旺、Ⅳeredetected諏thoo哪onHEdye岫gtoid鋤6fied∞s鞠phie西andS—P砸一mⅦ1dhistDch砸calmethodm35nasalpDlypsaIld15mf鰣Dfn

3、】rbIla匐∞Ande、，erymi∞衄坨se吐k帆wa5analysisedbyimageaIl燦bsy啦甄Re鼬b(1)P38MAPKandTNF一Ⅱexpress泌tbe髓dochyl髓迓ofnasalpdyps。孤dP—P38MAPKe】(凹翳in鋤d礎(chǔ)ylam_aandnl鴕dl】s，bexpression洫dldochyl刪皓was10werinnuceIus；arldinmferi。rtufbnates，P38M越)K、

4、P—P38M斌aI試椰一口exp麟smaII斕untSor∞expressionbeab—served(2)Theexp肥兩onofP38M臟墩in印itheliaIcellSand印ithelialcdlSofglands(14／35)wasob而ou曲higherinnaSal咖sthanthtIninfe血turb池曬(2／15)，theirdifferencehadsi鰣ficance(p005)Andthee)(pressho

5、fP—P38M舡Il(aIld耵師一amep—itklial幽and耋融烈cellsofgl舶(7／35，12／35)哪si礎(chǔ)icandyhigherm—nasalp。IypstharIt1atinirlf豳ftm婦t翳(1／15，2／15)，tlleirdiffe瞅讎hads酶溉ca!】ce(pO05)(3)TheexpDessiDnofP38M斌aIldn旺～口／P—P38MAPKandP38M雎Khad。。戒lated麗theac

6、hothermmSalp。Iyps觚l略io舾(1)Tentative∞艦tion，也eP13同垤APKs咖l廿Imsduc曲nherresdesiIlthepa幽09朗鶴yofna5al—yps，and唧ysac6v8teds協(xié)te(2)A陌vatedP38MAPKp0畦bledlr跚ghthewayofaugcn肌ttheexp礎(chǔ)函onofTr啦～口prote洫∞砬n鋤d破e璐ifym埔啦l涮la】∞mati∞r(nóng)eactando。腳