芪歸通脈飲對(duì)大鼠腦缺血保護(hù)的實(shí)驗(yàn)研究.pdf

1、山西醫(yī)科大學(xué)碩士學(xué)位論文芪歸通脈飲對(duì)大鼠腦缺血保護(hù)的實(shí)驗(yàn)研究姓名：張晉岳申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：神經(jīng)病學(xué)指導(dǎo)教師：朵振順20080508山西醫(yī)科大學(xué)碩士學(xué)位論文芪歸通脈飲對(duì)大鼠腦缺血保護(hù)的實(shí)驗(yàn)研究摘要目的：觀察芪歸通脈飲對(duì)大鼠腦缺血的保護(hù)作用。方法：以芪歸通脈飲灌胃大鼠，結(jié)扎大鼠雙側(cè)頸總動(dòng)脈，形成急性實(shí)驗(yàn)性不完全性腦缺血模型，觀察芪歸通脈飲對(duì)腦含水量、腦指數(shù)、腦毛細(xì)血管通透性及腦病理?yè)p傷的影響。Wistar大鼠140只，分成兩部分，每部

2、分隨機(jī)分為5組：每組14只，即：假手術(shù)組；腦梗死組；芪歸通脈飲125ml／kg組；芪歸通脈飲250ml／kg組；腦心通對(duì)照組。結(jié)果：芪歸通脈飲對(duì)實(shí)驗(yàn)性大鼠腦缺血所致腦含水量及腦指數(shù)的升高有顯著降低作用；對(duì)實(shí)驗(yàn)性大鼠腦缺血所致毛細(xì)血管通透性增加有顯著降低作用；能減輕腦組織病理?yè)p傷。結(jié)論：芪歸通脈飲對(duì)缺血性腦損傷具有明顯保護(hù)作用。關(guān)鍵詞：大鼠腦缺血，芪歸通脈飲，保護(hù)作用ExoerimentalStu01yAbstractObjective：

3、TostudyprotectiveactionagainsttheinjuryofcerebralischemiainratsMethods：EffectsofQiGuiTongMaiYinonbrainwatercontent，brainwetweightindexandcapillarypermeabilityofrmscausedanacutecerebralischemicbylilateralligationofcommonc

4、arotidwereobservde140Wistarratsweredividedinto2parts，andeachpartweredividedinto5groupsrandomly(Shamoperationgroup，CerebralInfarctiongroup，QiGuiTongMaiYin125ml／kggroup，QiGuiTongMaiYin250ml／kggroupandNaoXinTonggrouprespect

5、ively)，eachhas14ratsResults：TheresultsshowedthatQiGuiTongMaiYindecreasedsignificanllythebrainwatercontent，brainwetweightindex，andcapillarypermeabilityandreducedbrainhistopathologyinjuryofratswithacuteexperimentalcerebral