梅毒患者紅細(xì)胞CR1密度相關(guān)基因多態(tài)性研究.pdf

1、蘭州大學(xué)碩士學(xué)位論文梅毒患者紅細(xì)胞CR1密度相關(guān)基因多態(tài)性研究姓名：李世慎申請學(xué)位級別：碩士專業(yè)：皮膚病與性病學(xué)指導(dǎo)教師：李文竹20100601蘭州人學(xué)碩J：學(xué)位論文AStudyonCRlGeneDensityPolymorphismofErythrocyteinPatientswithSyphilisAbstractBackgroundSyphilisisachronicinfectiousdiseaseofgreatharmfuln

2、esscausedbyTreponemapallidum，mainlyspreadthroughsexualcontactandbloodThepathogenesisofsyphilisisnotcompletelyclearandtheexactcauseoftheserumfixedisnotclearAtpresentstudiesofthepathogenesisofsyphilisandthecausesofserumfix

3、edmainlyfocusedonleucocyteimmune，itisholdthattheincidenceofsyphilisandTcellmediatedimmuneresponsearecloselylinkedInrecentyears，erythrocyteimmunebecomeoneoftheresearchhotspotsofinfectiousdiseases，studieshaveshownthateryth

4、rocyteimmunefunctionsinpersonsinfectedwithTreponemapallidumweresignificantlyreduced，butstudyofCRlgenedensitypolymorphismonerythrocyteinpatientswithsyphilishasnotbeenreportedObjectiveToexploretheerythrocyteCRlgenedensityp

5、olymorphismfrequencyinpatientswithsyphilisMethodsCRlgenedensitypolymorphismwasmeasuredusingPCRamplificationfollowedbyHindIIIrestrictionenzymedigestionResultsThepercentagesofHH，HLandLLgenotypeswere5875％，35％and625％forsyphi

6、lispatients，and6875％，2625％and5％forhealthycontrols，respectivelyStatisticalanalysisshowedthatthereWasnosignificantdifferencebetweenthehealthycontrolsandsyphilispatientsp005)ThefrequencyofHLtypeandLLtypeofsyphilisgroupdidn’

7、tdifferfromthoseofthecontrolsp005)ConclusionPatientswithsyphiliswithlowererythrocyteimmunefunctionwerenotcloselyassociatedwiththedifferenterythrocytegenedensitypolymorphismKeywordsSyphilis；Erythrocyte；Complementreceptor1