中樞的惡性神經(jīng)鞘膜腫瘤—17例臨床研究報告.pdf

1、復旦大學碩士學位論文中樞的惡性神經(jīng)鞘膜腫瘤—17例臨床研究報告姓名：謝清申請學位級別：碩士專業(yè)：外科學指導教師：鮑偉民20030520復日大學碩十研究生畢業(yè)論文AbstractClinicalanalysison17casesofcentralmalignantnervesheathtumorsPurpose：‘rhroughanalyzingclinica]data()f‘a(chǎn)groupel’cenLralmalignantnerves

2、teathtumors(CMNST)，includingtumorswhichorigihatefromcranialnerveroot，spinalnerverootornearbycentralnervoussystem，wemayunderstandmoreaboutthiskindofFare1umorMethodandMaterials：FromJan1994to0ct2002，24CMNSTswerediagnosedand

3、treatedatourdepartment，HuashanhospJtal，17ofwhichhavebeenful1ydocumentedHereweretrospectivelYanalyzethem，whicharecategorizedintothreesubgroupsbytheirorigins，oneisfromcranialnerveFOOL，anotherisfromspinalnerveroot，theotheri

4、sfromunspecifiedcentralnerverootResult：Thereare11maleand6femalepatientsranginginagefrom3to65years(meanage，311)，onlY2ofwhichhavefibromatosishistoryThediseaseprogressingofCMNSTisfrom1monthto4years，10ofwhichshowedupsymptoms

5、in3monthsComputerizedtomography(CT)andmagneticresonanceimaging(MRI)revealstUmOFSmainlYinvasivegrowingwithhomogeneousenhancementHistologicallY，thetumorrellsiflthepredominant]Yhighrellularregionaremadeupofspindleshapednucl

6、eiandarrangedinstoriformpatterns，somewithcyst，hemorrhage，calcificatiOil，ornecrosisP1eomorphismandnumerousmitoticfiguresarenoted，buttypicalAntoniA／BstructuresarerareImmunohistoehemicallY。thetumorCellSaremostlYpositiveforS

7、100andVimentinproteJn7caseshadtumorstetalremoval，7casessubtotalremoval，and3partialremovalMostofthepatientsrecoveredquicklyafteroperations，andthe5yearSUFVivalratesareonlY235％though4patientsofthemhavesurvivedmorethan6years

8、Conclusion：TheCMNSTsaFemorecommoniYseeninchiIdrenortheelderwithnerverootoriginOFunspecifledoriginnearby，accordinglYshowingsymptomsandsignsorientedtotheregionoftumorsThec1inicaImanifestationofCMNSTisn’trathertypicalManage