上海市區(qū)卵巢癌危險(xiǎn)因素的病例—對(duì)照研究.pdf

1、復(fù)旦大學(xué)碩士學(xué)位論文上海市區(qū)卵巢癌危險(xiǎn)因素的病例—對(duì)照研究姓名：崔曉暉申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：流行病與衛(wèi)生統(tǒng)計(jì)學(xué)指導(dǎo)教師：金凡20030428Populationbasedmatchedease—controlstudyonepithelialovariancancerinurbanShanghai(Abstract)Objective：碭investigatethepossibleriskfactorsofepithelialovar

2、iancancerinShanghaiurbanwomenandprovidescientificevidenceforeffectivepreventionmeasnresMethods：In—personinterviewswerecompletedfor118casesnewly—diagnosedwithepithelialovariancanceraged3069fromJul2000toSep2001and118popula

3、tioncontrolsmmchedbyagetocollecttheinformationofpossibleriskfactorsCYPIAIgenotypewasdeterminedbyPCRbasedFRLPanalysisonDNAisolatedformbloodsamplesof74casesand96controlsResults：Bodymassindexinadult，waist—hipratioandintakeo

4、fanimalliverwerepositivelyassociatedwithriskofepithelialovariancancelAgeatmenarche(inpre—menopausewomen)，ageatmenopause(inpost—menopausewomen)，increasingmenstrualcycle，lactationandparity，andintakeofginseng，vegetablesandf

5、ruits，vitaminC，vitaminE，carotene，calciumwereinverselyassociatedwithriskofepithelialovariancancerCYPlAl(MspI)WillgenotypewassignificantlyassociatedwithhighriskofepithelialovariancancerinpremenopausewomenandpassivesmokersC

6、onclusions：EDithelialovariancancerwasassociatedwithmenstrualcyclesandobesity(especiallywithcentralobesity)Sheintakeofginseng，vegetablesandfruitsdecreasedtheriskofepithelialovariancancerCYPlAI(Mspl)variantallelemayberelat