卡馬西平的血液濃度和唾液濃度相關(guān)性研究.pdf

1、Objective: To determine the concentration ofcarbamazepine in epileptic patients plasma and saliva by TDX in fluorescence polarization immuno assay (FPIA), study their relativity ,inspect the possibility of using saliva i

2、nstead of plasma in clinical monitoring of carmabazepine .Methods: The total number of patients was 31 cases ,who had orally taken of CBZ 200mg-1300mg/day. Serum and saliva concentrations at 0 hours and 24 hours were m

3、easured by TDX in fluorescence polarization immuno assay (FPIA), and their relativity was studied by statistic methods. RESULTS: The concentration of CBZ in saliva at 0hours and 24hours had a mean of 1.01±0.79 μg·ml

4、-1 and 0.83±0.79 μg·ml-1respectively, the above values did not differ significantly from each other. The concentration of CBZ in plasma at 0 hours and 24hours had a mean of 2.39±1.37 μg·ml-1和 2.16±1.25 μg·ml-1respective

5、ly. The above values did not differ significantly from each other. The ratio of saliva concentration to plasma was (0.335±0.061).The relativity of the concentration of carmazepine in patients' plasma and saliva was quite

6、 good (the mean correlation coefficient was 0.659,P＜0.0001 ).Conclusions: High relativity may exist between the concentrations of carbamazepine in saliva and serum which is dynamic and parallel. So it is feasible to us