結(jié)直腸癌患者腫瘤組織中調(diào)節(jié)性T細胞（Tregs）水平及臨床意義.pdf

1、X1407273分類號：R7353密級：學位類別：科學學位回專業(yè)學位口學校代碼：10062學號：20052252又蚌普針^垮TIANJlNMEDICALUNlVERSITY碩士學位論文MASTER’SDISSERTATIoN論文題目：結(jié)直腸癌患者腫瘤組織中調(diào)節(jié)性T細胞(Tregs)水平及臨床意義TITLETheExpressLevelofRegulatoryTcells(Tregs)inCoiorectalCarcinomaandits

2、ClinicalSignificance一級學科：臨床醫(yī)學二級學科：外科學普外論文作者：李樹亮指導教師：朱理瑋教授導師組成員：逯寧副教授天津醫(yī)科大學研究生院二oo八年五月天津醫(yī)科大學碩士學位論文AbstractObjectiveInvestigatetheexpressofMacrophage—derivedchemokine(MDC)andthespecificmarkerofTregsforkhead／wingedhelixtran

3、scriptionfactor(Foxp3)incolorectalcarcinomaandthenanalyzetheircorrelationandtheirrelationshipwithclinico—pathologicalfeaturesofcolorectalcarcinomainordertoexploretheeffectofregulatoryTcells(Tregs)ontumorimmunityincolorec

4、talcarcinomaMaterialsandMethodsImmunofluorescencetechnique(IF)andimmunohistochemistry(IHC)wereusedtodeterminetheexpressivelevelsofFoxp3andMDCproteininspecimenscollectedfrom52patientswithcolorectalcarcinomawhichincludebot

5、htumorandtheproximalcuttingedge，whichwerepathologicallynormal，tocarryoutstatisticanalysiscomparedwithclinicalfeaturesResultsBoththeFoxp3andMDC’Sproteinexpressivelevelsincolorectalcarcinomaaresignificantlyhigherthanthatin

6、normalcontrol；ThereisstatisticalcorrelationbetweentheexpressivelevelsoftheFoxp3andMDCincolorectalcarcinoma，butinproximalnormaltissuesthereseemstobenelationship；TherearecorrelationsbetweenFoxp3expressivelevelsandcolorecta

7、lcarcinomainvasiveness，lymphaticmetastasis，pathologicalgradingaswellasDukesstagerespectivelybutnocorrelationbetweenFoxp3expressionandpathologicaltypingisfound；TherearecorrelationsbetweenMDCexpressivelevelsandcolorectalca

8、rcinomainvasiveness，lymphaticmetastasis，pathologicalgradingaswellasDukesstagerespectivelybutnocorrelationbetweenFoxp3expressionandpathologicaltypingisfoundConclusionTregsplayanimportantroleintheoccurrenceanddevelopmentof

9、colorectalcarcinoma，overexpressionofFoxp3isallimportantfactorthatrefraineffectiveanti—tumorimmunologicresponseandleadtotumorimmuneescape；MDC／CCL22CanattractCCR4十Tregcellstothetumor，wheretheycreateafavorableenvironmentfor