藻酸雙酯鈉對(duì)急性腦梗死的臨床效果及其機(jī)理研究.pdf

1、蘇州大學(xué)碩士學(xué)位論文藻酸雙酯鈉對(duì)急性腦梗死的臨床效果及其機(jī)理研究姓名：馬麗麗申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：血液內(nèi)科指導(dǎo)教師：王兆鉞尹明達(dá)20071001ClinicalE丘鰍ofPolysaccharideSul缸einPati即tsw油AcutcCelebraJIn衙ct鋤ditSMech姐i湖ClinicalEf!IfectofPolysaccharideSulfateinPatientswithAcuteCelebralInfarcta

2、nditsMechanismAbstract0bjective：Tostudyclinicalef聶x過(guò)ofpolysaccharidesulfateinpatientswithacutecelebralinfarct(ACI)anditSmechallismMethods：Patientssuf如ringfromAClwithinoneweekwererandomlydevidedinto3groupsreceiVingpolysac

3、charidesulfate(PSS)，aspirin(ASA)andticlopidine(TP)，respectiVely‘ThefoIlowingindicesweremeasuredbeforetreatmentand3d，7d，l4daftertr皇atment：plateletaggregationrate(PAGR)，pl私maP—selectin，也rombox齜圮B2(1Ⅻ2)inpa虹伽陷，PT，APTT，TT，nb

4、rinogen(Fg)，serumlipidsaswellasnerVousfhnctionResults：①PssinhibitedPAGinducedbyADPandarachidonicacid(AA)WhileASAmainlyinhibitedAAinducedPAG，andTPmainlyinhibitedADPinducedPAG(參PSS，ASAandTPdecreasedthelevelofplasmaPselecti

5、naftertreatmentthelevelofplasmaTXB2wasdecreasedsignificantlybyASAaftertreatment，butnotbyPSSorTP(螢APTTwasprolongedbyPSS，andPTwasslightlyprolonged，whileTTandFgwasnotchangedOntheotherhand，ASAandTPhadnoef代ctoncoagulationtest

6、s(DserumlipidwassignificantlydecreasedbyPSS，butnotbyASAorTP(9nervousfunctionwasbetterrecoVeredinPSSgroupthanASAandTPgroups‘ConcIusion：PSSshowsanantithromboticefIfectthrough1ipiddecrease，coagulationinhibitionandplateletin