鹽酸米諾環(huán)素緩釋凝膠的研究.pdf

1、大連理工大學碩士學位論文鹽酸米諾環(huán)素緩釋凝膠的研究姓名：張儉申請學位級別：碩士專業(yè)：應用化學指導教師：汪晴20060601鹽酸米諾環(huán)素緩釋凝膠的研究StudiesonFormulationofSustainedReleaseMinocyclineHydrochlorideGelAbstractTheinsitugelisaHewdrugdeliverysystem，whichis螄eetedteachsolidificationinth

2、etargetlocationbecauseoftheroleofbodyfluidsPeriodontitisisinflammationingum，InsitugellingisatechnologywhichissuitableforthetherapyofPeriodontitisMinocyclineHydrochlorideischosedasthemodelmedicineinbiopharmacy，physicalpha

3、rmaceutics，andothertheoreticalguidanceforthestudyoftreatmentofperiodontitisbylocalreleasepreparationPolymerCarbopol，sodiumpolyacrylateandcellulosederivativeECareadoptedasthemaindrugsustainedreleasingmaterialsTheparparedm

4、atrixcallreleaseMINOfor57daysThemethodofpreparationanalysisisoptimizedDissolutionrateisanimportantfactorofinfluencinginternalqualityAndthevariousfactorsarestudied，whichinfluencethegelofsustainedreleaseOrthogonalprojectis

5、employedtoscreentheprescriptionswhichbasedonthestudyofMINO—factorexperimentVerificationexperimentsaboutthereleasedrateofoptimizedprescriptionaredoneTheresultsshowedthatthereleasedrateofsustained—releasegelatlh，3h，7hwasl5

6、25％，30～50％and60～80％respectivelyThe五similarfactoranalysisexplainsthattherecurcapabilityofsustained—releaseMINOgelreleasingisgoodandthecraftisstableThroughthestudyofmassaccessorialdrug’sstability，theresultshowsthattemperat

7、urepHandtheionofacrylicacidhaveobviouseffectsonisomericchangeofchiralityofMINOTheresultofacceleratedtestindicatesthatM／NOinNOVERITE7Sisunstable，anditisrelativestableinCP，ECBytheroundedanalysisofthetwoexperimentsabove，weu

8、seECandCPasthecontrolledreleasematerialstooptimizetheformulation。IthasfewreportsaboutdevelopmentofsustainedreleaseM1NOgelinchinaSoitisaoriginalstudyTheresultsstudiedshowthatitisagoodfoundationofnewdeliverysystemwhichisus