環(huán)氧合酶-2和血管內(nèi)皮生長(zhǎng)因子在胃腸道間質(zhì)瘤中的表達(dá)及意義.pdf

1、中南大學(xué)碩士學(xué)位論文環(huán)氧合酶2和血管內(nèi)皮生長(zhǎng)因子在胃腸道間質(zhì)瘤中的表達(dá)及意義姓名：游錳申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：普通外科學(xué)指導(dǎo)教師：周建平20070501碩士學(xué)位論文英文摘要ABSTRACTObjectiveToinvestigatetheexpressionofCyclooxygenase一2(Cox一2)，vascularendothelialgrowthfactor(VEGF)ingastrointestinalstromaltum

2、ors(GIST)andtheirrelationshipwithhistopathologicalfeatures，toanalyzetheroleoftheminGISTandevaluatethecorrelationoftheirexpressionMethodsThemedicalrecordsincludinghistopathologicalfeaturesofpatientsdiagnosedGISTariseofthe

3、gastrointestinal(GOtractbetweenJan2003andDee2006wereretrievedfromXia嗡raHospital，SecondXiangyaHopital，ThirdXiangyaHospitalofCentralSouthUniveri哆andHunanCancerHospitalTumorslidesstainedwithhematoxylinandeosin(H&E)fromthese

4、patientswerereviewed1mmunohistochemistrystainingwereperformedusingantibodiestockitprotein(CDll7)andCD34GISTaredefinedasstromaltumorsoftheGItractthatexpressc—kitprotein(CDll7)and／orCD34SubsequentlyCox2andVEGFweredetectedi

5、mmunohistochemicallyandtherelationshipwasevaluatedbetweenhistopathologicfeaturesandexpressionofCox2andVEGFthecorrelationoftheirexpressionwasevaluatedatthesametimeResults(1)ThepositiveratesofCDll7、CD34、Cox一2andVEGFin104ca

6、sesGISTwererespectively856％，644％，76O％，683％(2)TheexpressionofCox一2andVEGFhadnosignificantrelationshipwithgenderage，aswell弱tumorsiteandsize，butitwassignificantlyrelatedtohistologicalsubtypeandhistologicalgradingofGIST(3)Co

7、x一2expressionhadpositivecorrelationtoVEGFexpressionConclusionTheexpressionofCox2andVEGFhadsignificantrelationshipwithhistologicalsubtypeandhistologicalgradingofGISTCox一2andVEGFmightplayanimportantroleintheproliferationan