宮頸癌中VEGF-C及其受體mRNA的表達(dá)及其臨床意義.pdf

1、Objective VEGF-C is ranked first as a lymphoangiogenic factor, which induces lymphatic proliferation and spread of solid tumors. Lymph node status remains the strongest prognostic factor in a variety of human malignant

2、tumors including uterine cervical carcinomas and lymphnode metastasis is promoted by tumor cell aggressiveness,such as abilities of motility and invasiveness. We examined the correlation between VEGF-C expression and tu

3、mor aggressiveness in cervical carcinomas with respect to clinicopathologic features and patient outcome. Objective To investigate the expression of vascular endothelial growth factor-C(VEGF-C) and its receptor in cervi

4、cal carcinoma tissue and their paratumour tissue in pursuit of their role in tumor metastasis and other clinical significance. Method 48 fresh cervical cancer tissue and their paratumour tissue were examined b

5、y RT-PCR to detected the VEGF-C/KDR/Flt-4mRNA expression. Results There was a significant difference of VEGF-C/KDR /Flt-4mRNA expression between the tumor, paratumour tissue and the normal controls. And there was

6、no significant relationship between VEGF-C mRNA, KDR mRNA or flt-4mRNA expression with the pathological types and clinical stage of invasive carcinoma of cervix.But the expression was significant associating with the gr

7、ade of tumor pathology, lymph node metastasis, tumor size and the invasion of deep muscular layer(p＜0.05). Conclusions The result suggest that the VEGF-C may play an important role in the lymph node metastasis and