Cervical Cancer and its associations with Vascular Endothelial Growth Factor and Cyclooxygenase-2.pdf

1、Objective: This study was carried out to research the expression of vascularendothelial growth factor (VEGF), cyclooxygenese-2 (COX-2) in cervical cancerof uterus and its clinical significance in cervical carcinoma.Me

2、thods: 42 cases of cancer cervix chosen from General Hospital in Tianjinwere included in this study. Immunohistochemistry was used to detect expressionof VEGF, COX-2, and CD34. To observe the expression of VEGF, COX-2

3、 andits relation with cervical carcinoma behaviour.Results:1. In 42 cases, 18(42.86％) VEGF positive, and 24(57.14％) VEGF negative. In26 cases with stage Ⅰ-Ⅱ, VEGF positive expression are 30.77％, whereas in those16 c

4、ases with stage Ⅲ-Ⅳ, VEGF positive expression are 62.5％, indicates thatVEGF expression has correlation with development of cervical carcinoma. In 37cases with squamous cell carcinoma, VEGF expression is 38.89％. In 5 ca

5、ses withadenocarcinoma, VEGF expression is 80％. VEGF expression is significanthigher in cervical adenocarcinoma than that in cervical squamous cell carcinoma.In 32 alive patients, VEGF expression is 31.25％, in 10 bad

6、prognosis patients,VEGF expression is 80％. VEGF expression is significant higher in bad prognosisthan that in good prognosis.2. The result of this study provides evidence that vascular endothelial growthfactor (VEGF)

7、 and micro vessels density (MVD) has close relation between thembecause in VEGF positive cases MVD is significant higher than that of VEGFnegative patients.( r =0.330,P＜0. 05)3. In 42 cases, 20(47.62％) COX-2 positive,

8、 and 22(52.38％) COX-2 negative.9(34.62％) out of total 26 patients with stage Ⅰ-Ⅱ were COX-2 positive expressionand 11(68.75％) out of 16 patients with stages Ⅲ-Ⅳ were COX-2 positiveexpression. In total 37(88.09％) cases

9、 of cervical squamous cell carcinoma17(45.95％) had COX-2 positive expression and out of 5 cervical adenocarcinoma3(60％) cases expressed COX-2 positive(X2=0.35,P＞0.05). Total 32 cases of alivepatients 15(46.88％) expres

10、sed COX-2 positive and out of 10 bad prognosispatients 5(50％) expressed COX-2 positive(X2=0.03,P＞0.05).4. Regression analysis indicates that VEGF expression is the prognostic factor inpatients with cervical cancer.Co

11、nclusion:1. VEGF expression is relation with clinical stage, pathological type, andprognosis in cervical carcinoma. Whereas COX-2 is only associates with clinicalstages of cervical carcinoma.2. VEGF can be taken as a