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1、IIIIII0IIOIDIDIIIDIDlID1101DIDIIDliDIII100hIDIIDIIIUS20170247767A1(19)UnitedStates(12)PatentApplicationPublication(10)Pub.No.:US20170247767AlLUetal.(43)Pub.Date:Aug.312017(54)BIOMARKERSFHEADNECKCANCERMETHODSOFTHEIRUSE(51
2、)Int.Cl.PublicationClassification(71)Applicant:THEREGENTSOFTHEUNiVERSITYOFCOLADOABODYCPATEDenverCO(US)(72)Invents:ShilongLUGreenwoodVillageCO(US)JohnSONGDenverCO(US)(21)Appl.No.:15519758(22)PCTFiled:Oct.162015(86)PCTNo.:
3、PCTU52015055958371(c)(1)(2)Date:Apr.172017RelatedU.S.ApplicationData(60)ProvisionalapplicationNo.62065122filedonOct.172014.C12Q168(2006.01)C12Q170(2006.01)(52)U.S.Cl.CPC...........C12Q16886(2013.01)C12Q1708(2013.01)CJ2Q2
4、600154(2013.01)CJ2Q2600156(2013.01)CJ2Q2600178(2013.01)(57)ABSTRACTDisclosedisadiagnosticpanelofmethylatedgenomiclociencodingmicrNA(mgmiR)markersthatdemonstrated90%sensitivity100%specificityinthedetectionofheadnecksquamo
5、uscellcarcinoma(HNSCC).TheseresultsrepresentthefirstuseofquantitativeMSPCRfthedetectionofmgmiRs.Inadditionthispaneldemonstratestheabilitytodetecthypermethylationintheadjacentmucosaofcancerpatientssuggestingitsutilityinea
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