1、中國協(xié)和醫(yī)科大學(xué)碩士學(xué)位論文Fin蛋白在結(jié)直腸腺瘤—癌中的表達(dá)及意義姓名:楊強(qiáng)申請(qǐng)學(xué)位級(jí)別:碩士專業(yè):病理學(xué)指導(dǎo)教師:陳杰盧朝輝20060101中國醫(yī)學(xué)科學(xué)院中國協(xié)和醫(yī)科大學(xué)碩士學(xué)位畢業(yè)論文Signi6canceoffhscinexpressionincolorectaladenomaandcarcinomaAbstractobjectiveFascm,a蚰mcturaUyulliqueaIldevolutionarilyconseⅣe
2、dactillbundingproteinthatisfoundinmembranerumes,microspikes,andstresS丘ber,inducesmembranepr咖sionsandincrcasescellInotilityinvarious饑msfonlledcellsThecxpressionoff瓠cinin印imelialneopl踟nshasbeendesc抽edonlyrecently,a11dVeryf
3、ewdataareavailableon也emleofthisproteinincolorectalcarcinomaForthispuIpose,mesignificanceoffascinproteinexpressionincolorectaladenomaandcarcinoma哪studiedimm咖ohistochemically_Methods4lcasesofcolor。吐alcarcinom如38casesofcolo
4、rectaladenomaand20casesofnonnaltissueswercimmunohistochcmicallyinvestigatedusingmonoclonala11tifascinantibodys詛iningmorethan5%oftIlInorcellswasrecordedaspositiveimm眥oreactivi夠ResunsOVemll,f瓠cinimmunoreacti、,itywaSdetec砌i
5、n17outof41casesofcolorectalcarcinoma(415%),9caseswereclassifiedaslowgradepositive,5caseswereimeⅡnediatcgradepositivc,卸d3caseswerelowgradeposmvebcreaseinlmunostaillingoff瓠cinwasseenl設(shè)elyint11elli曲gradecarc訪omaFascinexpres
6、sionwascorrelated麗thserosali11VaSion0=0005),llistopatllologicalgradingQ=0002),TNMstage(p=O叭1),positiVelymphnodemetaStasis0=o011),P53eXpression(p=O047)and硒一67expfession(p=0034),butnotcorrelatedwithage①=O412),gender(p=0326
7、)andllistolo百calclassification(p=0540)FaScinimmlmoreactivitywasdetectedin4outof17casesoflyIIlphnodemetastasis(235%),aIld3caseswereclassmedashi曲gradepos“ive,1caseswereiIltc珊edia_tegradepositiveFascinexpfessionWasolllyseen
8、in3outof27c器esofime衄ediatealldhighgradedysplasiaadenoma(1119∞,aIldthei姍unostainingwasfocalandweakFascinir衄unoreactivitywasnotdetectedinncasesoflow留吼dedysplasiaadenomaandno加altissuesConclusionInt11emumst印pathogenesisofcol