Fascin蛋白在結(jié)直腸腺瘤—癌中的表達(dá)及意義.pdf

1、中國協(xié)和醫(yī)科大學(xué)碩士學(xué)位論文Fin蛋白在結(jié)直腸腺瘤—癌中的表達(dá)及意義姓名：楊強(qiáng)申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：病理學(xué)指導(dǎo)教師：陳杰盧朝輝20060101中國醫(yī)學(xué)科學(xué)院中國協(xié)和醫(yī)科大學(xué)碩士學(xué)位畢業(yè)論文Signi6canceoffhscinexpressionincolorectaladenomaandcarcinomaAbstractobjectiveFascm，a蚰mcturaUyulliqueaIldevolutionarilyconseⅣe

2、dactillbundingproteinthatisfoundinmembranerumes，microspikes，andstresS丘ber，inducesmembranepr咖sionsandincrcasescellInotilityinvarious饑msfonlledcellsThecxpressionoff瓠cinin印imelialneopl踟nshasbeendesc抽edonlyrecently，a11dVeryf

3、ewdataareavailableon也emleofthisproteinincolorectalcarcinomaForthispuIpose，mesignificanceoffascinproteinexpressionincolorectaladenomaandcarcinoma哪studiedimm咖ohistochemically_Methods4lcasesofcolor。吐alcarcinom如38casesofcolo

4、rectaladenomaand20casesofnonnaltissueswercimmunohistochcmicallyinvestigatedusingmonoclonala11tifascinantibodys詛iningmorethan5％oftIlInorcellswasrecordedaspositiveimm眥oreactivi夠ResunsOVemll，f瓠cinimmunoreacti、，itywaSdetec砌i

5、n17outof41casesofcolorectalcarcinoma(415％)，9caseswereclassifiedaslowgradepositive，5caseswereimeⅡnediatcgradepositivc，卸d3caseswerelowgradeposmvebcreaseinlmunostaillingoff瓠cinwasseenl設(shè)elyint11elli曲gradecarc訪omaFascinexpres

6、sionwascorrelated麗thserosali11VaSion0=0005)，llistopatllologicalgradingQ=0002)，TNMstage(p=O叭1)，positiVelymphnodemetaStasis0=o011)，P53eXpression(p=O047)and硒一67expfession(p=0034)，butnotcorrelatedwithage①=O412)，gender(p=0326

7、)andllistolo百calclassification(p=0540)FaScinimmlmoreactivitywasdetectedin4outof17casesoflyIIlphnodemetastasis(235％)，aIld3caseswereclassmedashi曲gradepos“ive，1caseswereiIltc珊edia_tegradepositiveFascinexpfessionWasolllyseen

8、in3outof27c器esofime衄ediatealldhighgradedysplasiaadenoma(1119∞，aIldthei姍unostainingwasfocalandweakFascinir衄unoreactivitywasnotdetectedinncasesoflow留吼dedysplasiaadenomaandno加altissuesConclusionInt11emumst印pathogenesisofcol