應用適應性小動物PET靈敏度及空間分辨率的評估.pdf

1、華中科技大學碩士學位論文應用適應性小動物PET靈敏度及空間分辨率的評估姓名：蔣亞超申請學位級別：碩士專業(yè)：生物醫(yī)學工程指導教師：謝慶國20110126II華中科技大學碩士學位論文AbstractPositronEmissionTomography(PET)isakindofnoninvasiveimagingtechniquewhichcanprovidethreedimensionaltomographicimagesofradiot

2、racerdistribution.PETcandetecttheanimalhuman’sinvivometabolicchangesbiochemicalreactionsfunctionactivitiesinanoninvasivequantitativedynamicway.SmallanimalPETisdesignedfmolecularimagingofsmallanimalmodels.Itcanprovidealon

3、gitudinalcontinuousresearchonthesameanimal，monittheanimal’sphysiologicalbiochemicalprocessaswellastheeffectsofvatioustreatments.ComparedwithclinicalPETimagingsmallanimalPETimagingrequireshighersensitivityspatialresolutio

4、nespeciallyfthemouseimaging.DevelopingahighsensitivityhighresolutionsmallanimalPETisoneofthemajobjectivesinthisfeild.TherefePerfmanceevaluationofthesensitivityspatialresolutionofsmallanimalPETareofgreatimptance.Inthispap

5、erbasedontheNEMANU42008stardpublishedbytheNationalElectricalManufacturersAssociationweevaluatethesensitivityspatialresolutionofanalldigitalapplicationadaptivesmallanimalPETdevelopedbyourresearchgroupweaimtoobtainthesyste

6、m’sabsolutesensitivityaxialprofileofsensitivityspatialresolutionotherparameters.Thephysicalfactswhichaffectimpactthemeasurementresultsarealsostudied.Meanwhilethepreparationofthephantomsrequiredfperfmanceevaluationisintro

7、ducedinthispaper.WehopethatthiswkwillbenefitthefollowupresearchfurtherperfmanceevaluationofthesmallanimalPETsysteminourlabaty.Keywds:ApplicationadaptivesmallanimalPETPerfmanceevaluationSensitivity，SpatialresolutionPhanto