NMP22、BTAstat和B超聯(lián)合檢查在尿路上皮腫瘤診斷中的應(yīng)用.pdf

1、貴陽(yáng)中醫(yī)學(xué)院碩士學(xué)位論文NMP22、BTAstat和B超聯(lián)合檢查在尿路上皮腫瘤診斷中的應(yīng)用姓名：陳智申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：中西醫(yī)結(jié)合臨床外科指導(dǎo)教師：梁培育20090601貴陽(yáng)中醫(yī)學(xué)院碩：j學(xué)位論文AbstractObjective：ToassessthevalueofcombininguseofNMP22，BTAstatandultrasonographyinScreeningandSurveillanceofurothelialt

2、umor(UT)Methods：NMP22，BTAstatandultrasonographywerecarriedoutfor96symptomaticpatientssuspiciousofUToraftersurgicaltreatmentbeforecystoscopyPathologywasusedasthegoldstandardAnalyzethesensitivity(Se)，specificity(Sp)，positi

3、veperdictivevalue(PPV)andnegativeperdictivevaluefNPV)foreachandcombinedusinginurothelialtumorResults：41casesofbladdertransitionalcellcarcinoma(BTCC)and6casesofupperurinarytransitionalcellcarcinomawerediagnosedbypathology

4、49casesofpatientwereotherbenignurologicaldiseasesThemedianvalueofurinaryNMP22Was262_225U／mLinbladdertransitionalcellcarcinomas，andtheupperurinarytransitionalcellcarcinomasWas14482U／mL，respectlyBothofthemweresignificantly

5、higherthanthevalueofbenigndiseases(70t44U／mL)(P001)38casesofbladdertransitionalcellcarcinomaand5casesofupperurinarytransitionalcellcarcinomawerediagnosedbycombininguseofNMP22，BTAstatandultrasonographyWithcombineduseofthr

6、eemethedsinbladdertransitionalcell、”Vinoma，theSe(927％)Wasequaltothecystoscopy(927％)(P=1)andithigherthanthesingleoneuseofNMP22，BTAstatorultrasonography(PO05)ThecombinedSeWaselevatedwiththeinereasingofbladdertransitionalce

7、llcarcinomagradeandstageThecombinedSp(755％)waslowerthanthecystoscopy(939％)(PO05)ThecombinedPPV，NPVWas791％912％，respectlyDuringthecombineddiagnosis，12casesfalsepositiveUToccurrencedandthefalsepositiverateWas245％Conclusions