Livin、Caspase-3及Bcl-2在大腸腺癌組織芯片中的表達(dá)及臨床意義.pdf

1、蘇州大學(xué)碩士學(xué)位論文Livin、Caspase3及Bcl2在大腸腺癌組織芯片中的表達(dá)及臨床意義姓名：田天申請學(xué)位級別：碩士專業(yè)：病理學(xué)與病理生理學(xué)指導(dǎo)教師：馮一中20090401Livin、Caspase一3及Bcl2在大腸腺癌組織芯片中的表達(dá)及臨床意義英文摘要Exrandclinica’significanceofLivin、Caspase3andxoresslonanaclinicalsignilicanceivlnasoase3a

2、nd、Bcl一2incolorectaladenocarcinomawithtissuemicroarrayAbstractObjective：Toinvestigatetheexpressionandsignificanceofapoptosis—relatedgeneLivin、Caspase3andBcl2incolorectaladenocarcinomaMethods：Utilizinghighthroughouttissue

3、microarraysandimmunohistochemicalstreptavidinperosidase，theexpressionofLivin、Caspase3andBcl2wasdetectedin115casesofcolorectaladenocarcinoma，19casesofcolorectaladenomaand12casesofnormalcolorectalmucosaAndweanalyzetherelat

4、ionshipbetweenthesefactorsandclinicopathologiccharacteristicsaccordingtothesurvivaltimeof71caseswhichwerefollowupfrom6monthsto6yearsResults：ThepositiveexpressionofLivininnormalmucosaWas833％lowerthan1053％inadenoma(p005)an

5、d4957％incancerspecimens(P005)ThepositiveexpressionofCaspase一3innormalmucosawas8333o／6，higherthan4737％inadenoma(p005)and4174％incancerspecimens(P005)ThepositiveexpressionofBcl一2innormalmucosawas25％，lowerthan8421％inadenoma(

6、p005)and5826％incancerspecimens(P005)TheexpressionofLivin、Caspase3andBcl一2wassignificantlycorrelatedwithdegreeofdifferentiation(p005)，andLivin’SexpressionWasalselatedtolymphnodemetastasisandtumourinfiltratingdegree(p005)S

7、pearmanrankcorrelationshowedasignificantcooperativityamongLivin，Caspase3andBcl2protein(P001)ThepositiveexpressionofLivinandnegativeexpressionofCaspase一3weresignificantlyrelatedtoshotsurvivaltime(p005)Coxmultivariateanaly