22587.c17h15o3n3鑭系配合物的制備與性能研究

1、論文題目：C17H15O3N3鑭系配合物的制備與性能研究專業(yè)：應(yīng)用化學(xué)碩士生：宋超超(簽名)指導(dǎo)老師：劉向榮(簽名)摘要酰腙類化合物因其獨(dú)特的化學(xué)結(jié)構(gòu)以及優(yōu)良的生物活性，已廣泛應(yīng)用于化學(xué)、化工、生物和醫(yī)學(xué)等各個(gè)方面。本文將生物活性強(qiáng)的吲哚基引入到酰腙化合物中，合成了新型吲哚類酰腙化合物及其鑭系金屬配合物。主要工作如下：（1）以吲哚3甲酸甲酯為原料合成了未見報(bào)道的(3羥基4甲氧基苯甲醛)1H吲哚3甲酰腙(C17H15O3N3)，并在甲醇水

2、溶液中培養(yǎng)得到該化合物單晶。X射線單晶衍射結(jié)果說明晶體屬單斜晶系，空間群為P2(1)n，Z=4，晶胞參數(shù)為a=7.456(15)，b=23.793(5)，c=8.463(17)，α=90，β=93.763(4)，γ=90。（2）合成了C17H15O3N3及其12種鑭系金屬硝酸鹽的配合物，并通過元素分析、絡(luò)合滴定、紫外可見光譜和紅外光譜等手段進(jìn)行表征，推測配合物的組成為Ln[(C17H14O3N3)2(H2O)4](NO3)2H2O。（3

3、）通過TGDTG測試探究了C17H15O3N3及其12種鑭系配合物的熱分解過程和熱穩(wěn)定性，利用Kissinger和Ozawa公式計(jì)算了主要熱分解階段的熱動(dòng)力學(xué)參數(shù)。（4）利用紫外可見光譜和微量熱法，初步分析了C17H15O3N3及其12種鑭系配合物與小牛胸腺DNA的相互作用，發(fā)現(xiàn)配合物與小牛胸腺DNA的結(jié)合能力優(yōu)于配體。（5）利用微量熱法，測定C17H15O3N3與小麥條銹菌作用時(shí)的熱流變化情況，結(jié)果說明該化合物對(duì)小麥條銹菌具有抑菌活性

4、。關(guān)鍵詞:鑭系，配合物，合成，性質(zhì)研究類型:應(yīng)用基礎(chǔ)研究Subject:PreparationpropertiesofC17H15O3N3lanthanidecomplexesSpecialty:AppliedChemistryName:SongChaochao(Signature)Instruct:LiuXiangrong(Signature)ABSTRACTAcylhydrazonecompoundshavebeenwidelyus

5、edinmanyaspectssuchaschemistrychemicalengineeringbiologymedicinesincetheypocessuniquechemicalstructuregoodbiologicalactivity.Inthispaperweintroducedindolewhichhasstrongbiologicalactivityintoacylhydrazonecompoundtosynthsi

6、sanovelindoleacylhydrazonecompounditslanthanidemetalcomplexes.Themainresearchesareasfollows:(1)The(3hydroxy4methoxybenzaldehyde)1Hindole3carbohydrazone(C17H15O3N3)whichhasnotbeenreptedwaspreparedfromtheindole3methylfmate

7、itssinglecrystalwasobtainedbyslowevapationofmethanolaqueoussolution.TherestltsofXraycrystaldiffractionshowthatthecompoundcrystallizesinthemonoclinicspacegroupP2(1)nwithZ=4a=7.456(15)b=23.793(5)c=8.463(17)α=90β=93.763(4)γ

8、=90.(2)C17H15O3N3itscomplexesweresynthesizedacterizedbyelementalanalysiscomplexometryFTIRUVVisspectra.ItwasfoundthatthepossiblestructureofthecomplexisLn[(C17H14O3N3)2(H2O)4](NO3)2H2O.(3)Thethermaldecompositionprocessthet

9、hermalstabilityofC17H15O3N3itscomplexesweremeasuredbyTGDTGtheirapparentactivationenergieswerecalculatedbyKissinger’sOzawa’sequations.(4)TheabilityofC17H15O3N3itscomplexesbindingtoCTDNAwereinvestigatedbyUVVisspectramicroc

10、alimetryitwasfoundthatthebindingabilityofthecomplexeswithCTDNAwerebetterthanthelig.(5)ThereactionheatsofC17H15O3N3withPucciniaStriifmihavebeenmeasuredbymicrocalimetryexperimentstheresultssuggestthatthecompoundhaseffectiv