28380.運動誘導條件性味覺厭惡的內臟傳入途徑的研究

1、河北師范大學碩士學位論文運動誘導條件性味覺厭惡的內臟傳入途徑的研究姓名：王建偉申請學位級別：碩士專業(yè)：生理學指導教師：白文忠20100409IVAbstractConditionedtasteaversion（CTA）isatypeofassociativeconditioningthatthesubjectlearnstoassociateatastewithdelayedmalaise.Thecrelationoftastevisc

2、eraldiscomftisacriticalfactfthisphenomenon.Itisnowevidentthatphysicalexerciseinducesaversioninratstothetastepairedwiththeexerciseinrecentyearswhichsuggestssimilarroleinbothphysicalexercisegastrointestinaldiscomftasuncond

3、itionedstimulus（US）mightbeinvolvedinthedevelopmentoftasteaversion.HowevertheelucidationofphysiologicalvisceralprocessingunderlyingCTAinducedbyphysicalexerciseisstillinquestion.ToelucidatetheproblemadultmaleSpragueDawleyr

4、atsweretestedinthepresentexperiments.BefeafteracquisitionofaCTAagainstsucroseinducedbyswimmingratsunderwentbilateralsubdiaphragmaticvagotomyintraperitoneal（IP）injectionofgranisetronablatingthechemosensitiveareapostrema（A

5、P）.WeexpledthepossibleroleofthevagalafferentnervebloodbnevisceralstimulionacquisitionretentionofCTAinducedbyphysicalexerciseeffectsofAPlesiononratstasteresponsestodilutesacinsolutionafteracquisitionofaCTA.Thestudyfoundas

6、following：1、Fcedswimmingwith20mindurationcausedrelativelystrongaversiontothe0.1%sacinsolutionconsumedbefeswimming.HowevertheeffectivenessofswimmingwasweakerthanLiClinjectionasUSininducingconditionedtasteaversionwhichsugg

7、estedphysicalexercisehaveresultedinweakervisceralmalaise.2、CTAcouldbeslowlyinducedwhenratsunderwentbilateralsubdiaphragmaticvagotomyablatingAPpritothecrelationoftastestimulusexercisebutsignificantlyattenuatedbyIPinjectio

8、nofgranisetronwhichsuggestedvisceralinfmationrelayedbyafferentfibersoftheabdominalvagusnervechemosensitiveAPonlyplayapartofroleinCTAinducedbyphysicalexercise.Theincreasedsynthesisof5hydroxytryptamineinducedbyswimminginbr

9、ainmaybeimptantinexerciseinducedCTA.3、TheextinctionofCTAthatrepeatedsacinsolutionexposurewithoutsubsequentphysicalexercisewasacceleratedinratsunderwentsubdiaphragmaticvagotomyablatingAPafterlearnedCTA.Thismanifestedthati