綠色化學(xué)技術(shù)合成吡唑、嘧啶等雜環(huán)化合物.pdf

1、分類0：曹縱：’≯控代碼：10426、卜●j：200302010囊纛斜掇泰沓碩士研究生學(xué)位論文論文題目：綠色化學(xué)技術(shù)合成吡唑、姓名指導(dǎo)教師學(xué)科專業(yè)專業(yè)代碼研究方向嘧啶等雜環(huán)化合物郭維斯李明應(yīng)用化學(xué)081704有機合成SYNTHESISOFPYRAZOLE，PYRIMIDINEDERI、，ATIVESUSINGGREENCHEMICALTECHNoLoGYABSTRACTGreenchemistryisthemainlineofthewh

2、olepaperthesubjectswechoosearefollowingtheprincipleof“atomeconomy”TheobjectandapproachofgreensynthesiswasintroducedintheintroductionofthetextThemulticomponentreaction，especiallytheversatilebiologicalandpharmaceuticalacti

3、vitiesoftheBiglnelliproduct34一pyrimidine一2(1印‘onepⅢ’Ms)andtheimprovedmethodsofthereactionweresimplyintroduceinthefirstchapterThephysicochemicalproperties，syntheticmethodsandimprovementoftheorganicreactionsoftheroomtemper

4、atureionicliquids(RTIIJs)，whichWaSenormouslyresearchinrecentyearsweresimplyreviewedInthechapterthenewnontoxicRTIL1butyl3methylimidazolesaccharin([BMIm][Sac])WaSusedtoimprovetheBiginellireactionAnunexpectedphenomenonwasre

5、portedinthesecondChapter1“kvokindsofproductswereobtainedwhenthesolventandproportionoftheBigineUireactantswerechangedtoimprovetheBiglnellireactionApartfromtheDHPMs，anotherkindofcompoundswasobtainedThroughXraysinglecrystal

6、diffraction，鞏1HNMR”CNMR，theunknowncompoundWas14dihydropyridine(DRIP)，whichWastheproductofHantzschreactionTheHantzschreactionandtheversatileactivitiesofDHPswerealsointroducedinthechapterThesyntheticmethodsandapplicationin

7、organicsynthesisoftheenaminones，whichiswidelyusedrecentlyasanimportantintermediate，werereviewedinthethirdchapterFourteennewpyrazolo[1，5a]pyrimidinederivativesweresynthesizedusingenaminonesand1／／5一aminopyrazoleSomeofthene

8、wproductswereimprovedbymicrowaveradiationhcontrasttothetraditionalsyntheticmethod，underthemicrowaveradiationthesameproductsWereobtainedwithshorterreactiontimeandhigheryieldhIthechapterthedevelopmentofmicrowavechemistryth