松香基季銨鹽的合成及其抑菌活性初探.pdf

1、南京理工大學(xué)碩士學(xué)位論文松香基季銨鹽的合成及其抑菌活性初探姓名：張慧申請學(xué)位級別：碩士專業(yè)：應(yīng)用化學(xué)指導(dǎo)教師：蔣鵬舉20080627Abstract碩士論文AbstractRosinisallimportantnaturalresoul“ceofChinaAllkindsofresinacidsarethemaincomponentsofit，whichhavebeenputonmoreandmoreattentionfortheirs

2、pecialchemicalstructuresandwiderangeofbiologicalactivitiesFourtypesofquarternaryammoniumsbasedonrosinwerepreparedbyrosinorsodiumrosinateTheN一(4一abietoxymethyl)benzylNNNtrimethylammoniumchlorideandN一(4一abietoxymethyl)benz

3、ylN，N，Ntrimethylammoniumchlorideweresynthesizedforthefirsttime，andalsoaretheinnovationpointofthispaperInaddition，severalintermediatesweresyntheisized，whichcallprovidenewwaystoobtainquarternaryammoniumsFinally，theantibact

4、erialactivityofthemwaspreliminarilystudiedTheN(3abietoxy一2hydroxy)propylNNNtriethylammoniumchlorideWasobtmnedbytwowaysOneofthemisnewandhassomeadvantagesN(4abietoxymethyl)benzylNNNtrimethylammoniumchlorideandN一(4一abietoxy

5、methyl)benzylNNNtrimethylammoniumchlorideandtlleirintermediatesweresuccessfullypreparedEffectsofvariousfactorstothereactionoftheformer’Sintermediatewereoptimizedbythesinglefactorexperiments碭eoptimalreactionconditionsarea

6、sfollows：themolarradioof1，4bis(chloromethyl)benzenetotriethylamineis15：1，thesolventethanolcontentis60％(massfraction)，thetriethylamine’Sdroppingtimeisn’tlessthan10min，thereactiontimeis611，thetemperatureis65℃，andtheconvers

7、ionrateCanreach627％?！疊ythefilterpapermethod，theantibacterialactivitiesofthequartemaryammoniumbasedonrosinwereinverstigatedEscherichiacoliandaspergillusnigerwereselectedinthisexperimentIthasbeenfoundthatallofthemshowhigha

8、ntibacterialactivityandeventheactivityofN(4abietoxymethyl)benzylN，N，Ntrimethylammoniumchlorideishigherthanthebenzalkoniumbromide’SactivityKeywords：Sodiumrosinate，quartemaryammoniumbasedonrosin，epichlorohydrin1，4bis(chlor